An Australian halobacterium contains a novel proton pump retinal protein: archaerhodopsin.

abstract：:We report the functional and structural characterization of trehalose-6-phosphate phosphatase (TPP), from the Gram-negative bacterium B. pseudomallei that causes melioidosis, a severe infectious disease endemic in Southeast Asia and Northern Australia. TPP is a key enzyme in the trehalose biosynthesis pathway, which p...

journal_title：Biochemical and biophysical research communications

authors： Suthisawat S,Gourlay LJ,Bolognesi M,Boonyuen U,Vanaporn M

更新日期：2020-03-19 00:00:00

abstract：:It is now well established that PA is a potent biological response modifier, showing simultaneously antitumor, antitoxic, anticarcinogenic, antifungal, antiparasitic and immunomodulatory properties. Since PA is a foreign protein, it is quite logical to assume that it may be cleaved into smaller peptide fragments in vi...

journal_title：Biochemical and biophysical research communications

authors： Sinha P,Sengupta J,Ray PK

更新日期：1999-04-29 00:00:00

abstract：:The precursor of amphibian tachykinin has not been found although more than 30 tachykinins have been isolated from amphibians since 1964. In this report, two tachykinin-like peptides are identified from the skin secretions of the frog, Odorrana grahami. Their amino acid sequences are DDTEDLANKFIGLM-NH(2) (named tachyk...

journal_title：Biochemical and biophysical research communications

authors： Li J,Liu T,Xu X,Wang X,Wu M,Yang H,Lai R

更新日期：2006-12-01 00:00:00

abstract：:To identify the target autoantigens in Vogt-Koyanagi-Harada disease, we made use of an immunoscreening of a bovine uveal cDNA expression library with serum samples obtained from patients with Vogt-Koyanagi-Harada disease. We identified a novel bovine antigen and homologous human autoantigen and designated it as UACA (...

journal_title：Biochemical and biophysical research communications

authors： Yamada K,Senju S,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

更新日期：2001-02-02 00:00:00

abstract：:High performance liquid chromatographic (HPLC) analysis showed that the prototype antioxidant ascorbate (vitamin C) inhibits the DNA adducts induced by synthetic estrogen diethylstilbestrol (DES) and the antiestrogen metabolite 4-hydroxytamoxifen (4-OHTam). Treatment of salmon testes DNA with 4-OHTam quinone or 4-OHTa...

journal_title：Biochemical and biophysical research communications

authors： Sharma M,Slocum HK

更新日期：1999-09-07 00:00:00

abstract：:The products of the TSC1 (hamartin) and TCS2 (tuberin) tumor suppressor genes negatively regulate cell growth by inhibiting mTOR signaling. Recent research has led to the postulation that tuberin and/or hamartin are involved in tumor migration, presumably through Rho activation. Here we show that LEF-8 cells, which co...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Das SK,Inoue H,Kazami M,Hino O,Kobayashi T,Yeung RS,Kobayashi K,Tadokoro T,Yamamoto Y

更新日期：2008-03-28 00:00:00

abstract：:In several inflammatory conditions such as rheumatoid arthritis or sepsis, the regulatory mechanisms of inflammation are inefficient and the excessive inflammatory response leads to damage to the host. Sirtuins are class III histone deacetylases that modulate the activity of several transcription factors that are impl...

journal_title：Biochemical and biophysical research communications

authors： Fernandes CA,Fievez L,Neyrinck AM,Delzenne NM,Bureau F,Vanbever R

更新日期：2012-04-20 00:00:00

abstract：:Increasing evidence shows that immune-mediated mechanisms may contribute to the pathogenesis of central nervous system disorders including cerebellar ataxias, as indicated by the aberrant production of neuronal surface antibodies. We previously reported a patient with cerebellar ataxia associated with production of a ...

journal_title：Biochemical and biophysical research communications

authors： Yaguchi H,Yabe I,Takahashi H,Watanabe M,Nomura T,Kano T,Matsumoto M,Nakayama KI,Watanabe M,Hatakeyama S

更新日期：2017-12-09 00:00:00

abstract：:Horny Goat Weed is a commonly used in Chinese herbal medicine. And it is used in multiple kinds of diseases including cardiovascular diseases. Icariin is the major component isolated from Horny Goat Weed. It is reported to have lipid-lowering effect. In atherosclerosis, icariin attenuate the enhanced prothrombotic sta...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Wang YS,Song SL,Liang H,Ji AG

更新日期：2016-02-19 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) has been identified as a leading cause of tumor-associated death around the world. Presently, it is necessary to find effective and safe therapy for its treatment in clinic. Jervine (Jer), a sterodial alkaloid from rhizomes of Veratrum album, exhibits anti-inflammatory and anti-cance...

journal_title：Biochemical and biophysical research communications

authors： Lei W,Huo Z

更新日期：2020-12-10 00:00:00

abstract：:Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and f...

journal_title：Biochemical and biophysical research communications

authors： Dai Y,Liu L,Zeng T,Zhu YH,Li J,Chen L,Li Y,Yuan YF,Ma S,Guan XY

更新日期：2013-07-12 00:00:00

abstract：:Neuropathic pain is triggered by damage to or as a result of the dysfunction of the somatosensory nervous system. Gene expression profiling using DNA microarray and real-time PCR have emerged as powerful tools for the elucidation of pain-specific pathways and identification of candidate biomarkers and therapeutic targ...

journal_title：Biochemical and biophysical research communications

authors： Wan G,Yang K,Lim Q',Zhou L,He BP,Wong HK,Too HP

更新日期：2010-10-01 00:00:00

abstract：:The compounds [Pt(IV)(dach)(9-methylguanine)2X2]2+ (X = Cl, OH) have been prepared and structurally characterized. Their existence shows that it is possible to accommodate two purine bases (in a cis configuration) and four other ligands around a Pt(IV) atom. The geometries of these complexes have very different orient...

journal_title：Biochemical and biophysical research communications

authors： Choi HK,Huang SK,Bau R

更新日期：1988-11-15 00:00:00

abstract：:Arrestins have important roles in G protein-coupled receptor (GPCR) signaling including desensitization of GPCRs and G protein-independent signaling. There have been four arrestins identified: arrestin1, arrestin2 (e.g. β-arrestin1), arrestin3 (e.g. β-arrestin2), and arrestin4. β-Arrestin1 and β-arrestin2 are ubiquito...

journal_title：Biochemical and biophysical research communications

authors： Yun Y,Kim DK,Seo MD,Kim KM,Chung KY

更新日期：2015-01-30 00:00:00

abstract：:Regenerating gene (Reg) I has been identified as a regenerative/proliferative factor for pancreatic islet cells. We examined Reg I expression in the regenerating liver of a rat model that had been administered 2-acetylaminofluorene and treated with 70% partial hepatectomy (2-AAF/PH model), where hepatocyte and cholang...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Koyota S,Zhou X,Ueno Y,Ma L,Kawagoe M,Koizumi Y,Okamoto H,Sugiyama T

更新日期：2009-03-13 00:00:00

abstract：:BALB/c mice were immunized with rIGF-II receptors purified from 18-54, SF cells by chromatography of solubilized receptors over agarose-immobilized rIGF-II. Two fusions of splenic lymphocytes with FO mouse myeloma cells yielded 27 stable hybrids which were positive by ELISA. Cloning of seven of these hybrids yielded 3...

journal_title：Biochemical and biophysical research communications

authors： Rosenfeld RG,Pham H

更新日期：1987-07-31 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic hepatitis C (CH-C) and is epidemiologically linked with the occurrence of hepatocellular carcinoma (HCC). To elucidate the comprehensive gene expression profiles of CH-C and HCC, serial analysis of gene expression (SAGE) libraries were made from CH-C and HCC tissues of a patient,...

journal_title：Biochemical and biophysical research communications

authors： Yamashita T,Kaneko S,Hashimoto S,Sato T,Nagai S,Toyoda N,Suzuki T,Kobayashi K,Matsushima K

更新日期：2001-03-30 00:00:00

abstract：:Groucho is a corepressor that forms a macromolecular complex for its corepressor activity, in which HDAC1 is an essential component for the modulation of chromatin structure and transcriptional repression of target genes. Here, we show that Groucho is covalently conjugated with small ubiquitin-related modifier-1 (SUMO...

journal_title：Biochemical and biophysical research communications

authors： Ahn JW,Lee YA,Ahn JH,Choi CY

更新日期：2009-01-30 00:00:00

abstract：:Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells adapt to hyposmotic stress including that of regulatory volume decrease. In ischemia and reperfus...

journal_title：Biochemical and biophysical research communications

authors： Díaz-Elizondo J,Chiong M,Rojas-Rivera D,Olea-Azar C,Kwon HM,Lavandero S

更新日期：2006-12-01 00:00:00

abstract：:We have previously reported that endothelin-1 (ET-1) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the involvement of Rho-kinase in the ET-1-stimulated I...

journal_title：Biochemical and biophysical research communications

authors： Tokuda H,Hanai Y,Matsushima-Nishiwaki R,Yamauchi J,Doi T,Harada A,Takai S,Kozawa O

更新日期：2007-11-03 00:00:00

abstract：:Phosphofructokinase-2 from rat liver is inhibited by phosphoenolpyruvate and ADP. Phosphoenolpyruvate reduces the maximum activity in respect to fructose-6-phosphate and ATP but does not give rise to complete inhibition of phosphofructokinase-2. ADP increases the apparent Michaelis constant of the enzyme for ATP and l...

journal_title：Biochemical and biophysical research communications

authors： Kretschmer M,Hofmann E

更新日期：1984-11-14 00:00:00

abstract：:Plastocyanin (PC) is a copper protein that serves as a mobile electron carrier between cytochrome f and Photosystem I in the light reactions of photosynthesis. Despite large variability in amino acid sequences and isoelectric points, PCs from cyanobacterial and chloroplast sources reveal considerable similarities with...

journal_title：Biochemical and biophysical research communications

authors： Babu CR,Arudchandran A,Hille R,Gross EL,Bullerjahn GS

更新日期：1997-06-27 00:00:00

abstract：:Tubby domain superfamily protein (TUSP) is a distant member of the Tubby-like protein (TULP) family. Although other TULPs play important roles in sensation, metabolism, and development, the molecular functions of TUSP are completely unknown. Here, we explore the function of TUSP in the Drosophila nervous system where ...

journal_title：Biochemical and biophysical research communications

authors： Yoon EJ,Jeong YT,Lee JE,Moon SJ,Kim CH

更新日期：2017-01-22 00:00:00

abstract：:A baculovirus expression system has been used to express large quantities of full-length, biologically active Xenopus fibroblast growth factor receptor-1. Recombinant XFGFR-1 was purified to near homogeneity by a single step immunoaffinity purification procedure. The recombinant XFGFR-1 binds both FGF-1 and FGF-2 with...

journal_title：Biochemical and biophysical research communications

authors： Brown SA,Friesel R

更新日期：1993-06-30 00:00:00

abstract：:The tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL or Apo2L) and its receptors are members of the tumor necrosis factor superfamily. TRAIL triggers apoptosis by binding to its two proapoptotic receptors DR4 and DR5, a process which is negatively regulated by binding of TRAIL to its two decoy rece...

journal_title：Biochemical and biophysical research communications

authors： Sun SY,Yue P,Zhou JY,Wang Y,Choi Kim HR,Lotan R,Wu GS

更新日期：2001-01-26 00:00:00

abstract：:Cardiac ryanodine receptor gene (RyR2) mutations cause fatal arrhythmogenic diseases such as catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right ventricular cardiomyopathy. The N-terminal region of RyR2 is one of the hot spots for mutations. In this study, we investigated cardiac phenotypes ...

journal_title：Biochemical and biophysical research communications

authors： Okudaira N,Kuwahara M,Hirata Y,Oku Y,Nishio H

更新日期：2014-09-26 00:00:00

abstract：:Using antibodies to the procollagen C-proteinase enhancer of mouse fibroblast culture medium, we have screened by immunoblotting extracts of several post natal mouse and rat tissues for the presence of the enhancer antigen. All rodent connective tissues were relatively rich in enhancer; lower amounts were found in ske...

journal_title：Biochemical and biophysical research communications

authors： Kessler E,Mould AP,Hulmes DJ

更新日期：1990-11-30 00:00:00

abstract：:From a lambda UNI-ZAP XR cDNA library derived from poly(A)+RNA of human ovarian granulosa cells a cDNA clone pHG51 was isolated. Sequence analysis showed significant homology to the C-terminal region of rat ribosomal protein L8 cDNA. The 5'-end of the cDNA was completed by PCR with cloned total cDNA. Aligning of DNA s...

journal_title：Biochemical and biophysical research communications

authors： Hanes J,Klaudiny J,von der Kammer H,Scheit KH

更新日期：1993-12-30 00:00:00

abstract：:We investigated mechanisms of cytotoxicity induced by doxycycline (doxy) and minocycline (mino) in the chronic myeloid leukemia K562 cell line. Doxy and mino induced cell death in exposure-dependent manner. While annexin V/propidium iodide staining was consistent with apoptosis, the morphological changes in Giemsa sta...

journal_title：Biochemical and biophysical research communications

authors： Fares M,Abedi-Valugerdi M,Hassan M,Potácová Z

更新日期：2015-07-31 00:00:00

abstract：:The polycystic kidney disease (PKD) 1L3-PKD2L1 channel is a candidate sour taste receptor expressed in mammalian taste receptor cells. Various acids are reported to activate PKD channels after the removal of the acid stimuli, but little information is available on the activation of these channels by acetic acid. It wa...

journal_title：Biochemical and biophysical research communications

authors： Ishii S,Misaka T,Kishi M,Kaga T,Ishimaru Y,Abe K

更新日期：2009-07-31 00:00:00