当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages.

Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages.

Abstract：

:In several inflammatory conditions such as rheumatoid arthritis or sepsis, the regulatory mechanisms of inflammation are inefficient and the excessive inflammatory response leads to damage to the host. Sirtuins are class III histone deacetylases that modulate the activity of several transcription factors that are implicated in immune responses. In this study, we evaluated the impact of sirtuin inhibition on the activation of lipopolysaccharide (LPS)-stimulated J774 macrophages by assessing the production of inflammatory cytokines. The pharmacologic inhibition of sirtuins decreased the production of tumour necrosis factor-alpha (TNF-α) interleukin 6 (IL-6) and Rantes. The reduction of cytokine production was associated with decreased nuclear factor kappa B (NF-κB) activity and inhibitor kappa B alpha (IκBα) phosphorylation while no impact was observed on the phosphorylation status of p38 mitogen-activated kinase (p38 MAPK). This work shows that sirtuin pharmacologic inhibitors are a promising tool for the treatment of inflammatory conditions.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fernandes CA,Fievez L,Neyrinck AM,Delzenne NM,Bureau F,Vanbever R

doi

10.1016/j.bbrc.2012.03.088

subject

Has Abstract

pub_date

2012-04-20 00:00:00

pages

857-61

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00548-7

journal_volume

420

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • alpha-Crystallin facilitates the reactivation of hydrogen peroxide-inactivated rhodanese.

    abstract：:It was previously shown that rhodanese, inactivated with hydrogen peroxide, could only be reactivated in the presence of a reductant or the substrate thiosulfate if these reagents were added soon after inactivation and if the oxidant was removed. Here, we report on the facilitated reactivation (75%) of hydrogen peroxi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3165

    authors： Del Fierro D,Zardeneta G,Mendoza JA

    更新日期：2000-08-02 00:00:00

  • Mechanism and significance of specific proteolytic cleavage of Reelin.

    abstract：:Reelin is a secreted glycoprotein essential for normal brain development and function. In the extracellular milieu, Reelin is subject to specific cleavage at two (N-t and C-t) sites. The N-t cleavage of Reelin is implicated in psychiatric and Alzheimer's diseases, but the molecular mechanism and physiological signific...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.01.039

    authors： Kohno S,Kohno T,Nakano Y,Suzuki K,Ishii M,Tagami H,Baba A,Hattori M

    更新日期：2009-02-27 00:00:00

  • SAPAP4 Deletion Causes Synaptic Dysfunction in the nucleus accumbens.

    abstract：:SAP90/PSD95-associated proteins (SAPAPs) are one type of scaffold protein in the postsynaptic density (PSD). Scaffold proteins play an important role in synaptic function. Recently, many studies have shown that mutations associated with scaffold proteins cause dysfunction in neuronal circuitry and in behavior. SAPAP4,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.10.016

    authors： Wu B,Li C,Lei H

    更新日期：2018-11-10 00:00:00

  • Properties and secondary structure analysis of BanI endonuclease: identification of putative active site.

    abstract：:Biochemical properties of Type II restriction enzyme BanI were characterized. Kinetic parameters were evaluated and an enhancement of rate was observed when the recognition site was located in a more central position in the substrate, suggesting that BanI locates its recognition site by a sliding mechanism. As BanI ha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3621

    authors： Advani S,Roy KB

    更新日期：2000-12-09 00:00:00

  • Cancer biomarkers in atherosclerotic plaque: Evidenced from structural and proteomic analyses.

    abstract：:Atherosclerosis and cancer are the leading causes of mortality around the world that share common pathogenic pathways. The aim of this study is the investigation of the protein profile of atherosclerotic plaque in order to find similar biomarker between cancer and atherosclerosis. The small pieces of human coronary ar...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.12.160

    authors： Fasehee H,Fakhraee M,Davoudi S,Vali H,Faghihi S

    更新日期：2019-02-12 00:00:00

  • Measuring inputs to a common function: The case of Dlx5 and Dlx6.

    abstract：:Physically linked Dlx5 and Dlx6 paralogs are co-expressed in vertebrates and various combinations of null alleles in mice demonstrate not only functional redundancy between the paralogous factors but a similar quantitative contribution to craniofacial functions during development. While it is not possible to rule out ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.07.044

    authors： Quach A,MacKenzie RK,Bendall AJ

    更新日期：2016-09-09 00:00:00

  • Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.

    abstract：:Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca(2+)-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due to abolished channel c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.062

    authors： Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

    更新日期：2007-11-23 00:00:00

  • Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism.

    abstract：:Proadrenomedullin N-terminal 20 peptide (PAMP) is a regulatory peptide that is found in various cell types. It is involved in many biological activities and is rich in basic and hydrophobic amino acids, a common feature of antimicrobial peptides (AMPs). In this study, the cell selectivity and antimicrobial mechanism o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.04.063

    authors： Ajish C,Yang S,Kumar SD,Shin SY

    更新日期：2020-06-30 00:00:00

  • Inhibitory and enhancing effects of insertion of central polypurine tract sequence on gene expression with vectors derived from human immunodeficiency virus type 1.

    abstract：:Reportedly, in human immunodeficiency virus type 1 (HIV) vectors, insertion of central polypurine tract (cPPT) increased expression of transgenes for a short period. To test this for a stable condition, we constructed a series of vectors carrying a Neo(r) gene as a stable marker driven by a synthetic thymidine kinase ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00212-2

    authors： Sakuma R,Kobayashi N,Ae K,Kitamura Y

    更新日期：2003-03-14 00:00:00

  • MMP-mediated cleavage of beta-dystroglycan in myelin sheath is involved in autoimmune neuritis.

    abstract：:Alpha-/beta-dystroglycans (DG) located at the outmost layer of myelin sheath play a critical role in its formation and stability in the peripheral nerve system. The demyelination of nerve fibers is present in autoimmune neuritis, however, it is not known about the molecular mechanisms underlying this pathological proc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.01.062

    authors： Zhao XL,Li GZ,Sun B,Zhang ZL,Yin YH,Tian YS,Li H,Li HL,Wang de S,Zhong D

    更新日期：2010-02-19 00:00:00

  • Chemical modification of hemoglobin improves biocatalytic oxidation of PAHs.

    abstract：:Chemical modifications on human hemoglobin were performed with the aim to change both surface and active-site hydrophobicities. The modifications included covalent coupling of poly(ethylene)glycol (5000 MW) on free amino groups and the methyl esterification of free carboxylic groups. The modified hemoglobin was assaye...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3016

    authors： Torres E,Vazquez-Duhalt R

    更新日期：2000-07-14 00:00:00

  • Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal.

    abstract：:Cytosolic prostaglandin (PG) E synthase (cPGES) is constitutively expressed in various cells and regulates cyclooxygenase (COX)-1-dependent immediate PGE(2) generation. Its primary structure is identical to co-chaperone p23, a heat shock protein 90 (Hsp90)-binding protein. We have revealed that Hsp90 regulated both cP...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.180

    authors： Nakatani Y,Hokonohara Y,Kakuta S,Sudo K,Iwakura Y,Kudo I

    更新日期：2007-10-19 00:00:00

  • Carbohydrate chains and phosphatidylserine successively work as signals for apoptotic cell removal.

    abstract：:At an early stage of apoptosis, Jurkat cells transiently become susceptible to binding and phagocytosis by macrophages through the polylactosamine-type carbohydrate chains of CD43 [J. Biol. Chem. 279 (2004) 5967]. Susceptibility of apoptotic Jurkat cells to macrophage recognition was studied over an extended time rang...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.12.171

    authors： Yamanaka M,Eda S,Beppu M

    更新日期：2005-03-04 00:00:00

  • Naringenin is a novel inhibitor of Dictyostelium cell proliferation and cell migration.

    abstract：:Naringenin is a flavanone compound that alters critical cellular processes such as cell multiplication, glucose uptake, and mitochondrial activity. In this study, we used the social amoeba, Dictyostelium discoideum, as a model system for examining the cellular processes and signaling pathways affected by naringenin. W...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.047

    authors： Misty R,Martinez R,Ali H,Steimle PA

    更新日期：2006-06-23 00:00:00

  • Development of xeno-free epithelial differentiation media for adherent, non-expanded adipose stromal vascular cell cultures.

    abstract：INTRODUCTION:Reconstruction of respiratory epithelium is critical for the fabrication of bioengineered airway implants. Epithelial differentiation is typically achieved using bovine pituitary extract (BPE). Due to the xenogenic nature and undefined composition of BPE, an alternative for human clinical applications, dev...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.08.104

    authors： Hintze JM,Tchoukalova YD,Sista R,Shah MK,Zhang N,Lott DG

    更新日期：2018-09-18 00:00:00

  • Human adipose-derived stem cells and simvastatin-functionalized biomimetic calcium phosphate to construct a novel tissue-engineered bone.

    abstract：:To repair bone defects, we evaluate the in-vitro and in-vivo osteogenic activities of a novel tissue-engineered bone (TEB) by elaborately combining biomimetic calcium phosphate (BioCaP) granules with internally-incorporated simvastatin (SIM) and human adipose-derived stem cells (hASCs). First, we constructed BioCaP wi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.11.150

    authors： Zhang X,Jiang W,Liu Y,Zhang P,Wang L,Li W,Wu G,Ge Y,Zhou Y

    更新日期：2018-01-01 00:00:00

  • Histone-H1 inhibits translation by reticulocyte lysates with relative mRNA selectivity.

    abstract：:Histone-H1 purified from rat skeletal muscle is a relatively potent inhibitor of peptide chain initiation in a cell free system, the rabbit reticulocyte lysate (50% inhibition at approximately 0.4 microM). H1 does not inhibit formation of the ternary complex nor its attachment to 40S ribosomes; the data are compatible...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80514-4

    authors： O'Leary NE,Cheema IR,Moore K,Mehard WB,Buse MG

    更新日期：1987-04-14 00:00:00

  • Regulation of c-myc through intranuclear localization of its RNA subspecies.

    abstract：:We used fluorescence in situ hybridization (FISH) to detect c-myc RNA subspecies in human COLO 320DM tumor cells. Although the FISH procedure removed the majority of RNAs from the nucleolus, c-myc RNA continued to be detected in both the nucleoplasm and nucleolus. This finding suggests stable association between c-myc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.201

    authors： Shimizu N,Kawamoto JK,Utani K

    更新日期：2007-08-03 00:00:00

  • Characterization of the BUD31 gene of Saccharomyces cerevisiae.

    abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.228

    authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

    更新日期：2004-08-06 00:00:00

  • Characterization of the specific interaction between archaeal FHA domain-containing protein and the promoter of a flagellar-like gene-cluster and its regulation by phosphorylation.

    abstract：:The mechanism and target genes of regulation by Forkhead (FHA) domain-containing transcription factors have not yet been documented in Archaea. In this study, using a bacterial one-hybrid technique, we successfully screened and identified for the first time a target gene regulated by ST0829, an FHA domain-containing p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.03.011

    authors： Duan X,He ZG

    更新日期：2011-04-01 00:00:00

  • Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer.

    abstract：:MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS) miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to the difficulties in miRNA delivery, warranting the development of a novel drug delivery system (DDS). Exosomes are stable in circulat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.04.076

    authors： Kobayashi M,Sawada K,Miyamoto M,Shimizu A,Yamamoto M,Kinose Y,Nakamura K,Kawano M,Kodama M,Hashimoto K,Kimura T

    更新日期：2020-06-18 00:00:00

  • Calcium-activated, calmodulin-dependent protein kinase activity in bovine thyroid cytosol.

    abstract：:Bovine thyroid 100,000 X g supernatant contained calcium-activated, calmodulin-dependent protein kinase (PK-CaM) activity. The PK-CaM was partially purified using ion-exchange chromatography and characterized. PK-CaM, using casein as exogenous substrate, was not stimulated by Ca2+(0-500 microM) or calmodulin (1-10 mic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91066-1

    authors： Friedman Y,Henricks L,Poleck T,Levasseur S,Burke G

    更新日期：1986-10-15 00:00:00

  • MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1.

    abstract：:Rap1 and Rap2 are similar Ras-like G proteins but perform distinct functions. By the affinity chromatography/mass-spectrometry approach and the yeast two-hybrid screening, we identified Misshapen/NIKs-related kinase (MINK) as a novel Rap2-interacting protein that does not interact with Rap1 or Ras. MINK is a member of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.038

    authors： Nonaka H,Takei K,Umikawa M,Oshiro M,Kuninaka K,Bayarjargal M,Asato T,Yamashiro Y,Uechi Y,Endo S,Suzuki T,Kariya KI

    更新日期：2008-12-12 00:00:00

  • Degradation of DNA by metalloanthracyclines: requirement for metal ions.

    abstract：:Metallodaunomycin has been shown to cleave DNA only in the presence of oxygen, a reducing agent and a metal ion under reaction conditions similar to those used for the cuprous-phenanthroline complex. The intermediacy of 02-. and H2O2 has been substantiated by experiments with superoxide dismutase and catalase, respect...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90868-5

    authors： Mariam YH,Glover GP

    更新日期：1986-04-14 00:00:00

  • Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase.

    abstract：:Human glutathione synthetase is responsible for catalyzing the final step in glutathione biosynthesis. It is a homodimer with a monomer subunit MW of 52 kDa. Kinetic analysis reveals a departure from linearity of the Lineweaver-Burk double reciprocal plot for the binding of gamma-glutamyl substrate, indicating coopera...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5961

    authors： Njalsson R,Norgren S,Larsson A,Huang CS,Anderson ME,Luo JL

    更新日期：2001-11-23 00:00:00

  • miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression.

    abstract：:microRNAs (miRNAs) are non-coding small RNAs regulating gene expression, cell growth, and differentiation. Although several miRNAs have been implicated in cell growth and differentiation, it is barely understood their roles in adipocyte differentiation. In the present study, we reveal that miR-27a is involved in adipo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.01.012

    authors： Kim SY,Kim AY,Lee HW,Son YH,Lee GY,Lee JW,Lee YS,Kim JB

    更新日期：2010-02-12 00:00:00

  • Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation.

    abstract：:Simvastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor widely used for the treatment of hypercholesterolemia. Recent data indicates that simvastatin increases the risk of new-onset diabetes by impairing both insulin secretion and insulin sensitivity. However, systematic evaluation of mechanistic pathways ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.10.026

    authors： Yaluri N,Modi S,Kokkola T

    更新日期：2016-11-11 00:00:00

  • Differential expression of the transcription factor NF-kappaB during human mononuclear phagocyte differentiation to macrophages and dendritic cells.

    abstract：:An important role for the Rel/NF-kappaB family of transcription factors in the differentiation process of dendritic cells (DC) and macrophages (MAC) was recently suggested by a number of mouse knockout studies but only little information is available for defined populations of human cells. To investigate the role of i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.2083

    authors： Ammon C,Mondal K,Andreesen R,Krause SW

    更新日期：2000-02-05 00:00:00

  • Calyculin A, okadaic acid and W-7 interfere with a distal step in pancreatic acinar signal transduction.

    abstract：:The effects of the serine/threonine phosphatase inhibitors calyculin A, okadaic acid and the calmodulin antagonist W-7 on amylase secretion were studied in pancreatic acini. Calyculin A and okadaic acid dose-dependently inhibited amylase secretion to basal levels when stimulated with the intracellularly acting secreta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1869

    authors： Meyer-Alber A,Fetz I,Waschulewski IH,Höcker M,Fölsch UR,Schmidt WE

    更新日期：1994-06-30 00:00:00

  • Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution.

    abstract：:Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. To elucidate the origins and evolution of ERs and ERRs, we searched for their orthologs in the recently sequenced ge...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.08.047

    authors： Baker ME

    更新日期：2008-10-31 00:00:00