当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.

Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.

Abstract：

:Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca(2+)-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due to abolished channel crosstalk in Purkinje cells (PCs). To precisely understand aberrations in JP-DKO mice, we further analyzed the mutant PCs. During the induction of cerebellar plasticity via electrical stimuli, JP-DKO PCs showed insufficient depolarizing responses. Immunochemistry detected mild impairment in synaptic maturation and hyperphosphorylation of protein kinase Cgamma in JP-DKO PCs. Moreover, gene expression was slightly altered in the JP-DKO cerebellum. Therefore, the mutant PCs bear marginal but widespread abnormalities, all of which likely cause cerebellar motor defects in JP-DKO mice.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

doi

10.1016/j.bbrc.2007.09.062

subject

Has Abstract

pub_date

2007-11-23 00:00:00

pages

835-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)02031-1

journal_volume

363

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Validation and quantitation of an in vitro M-cell model.

    abstract：:This study has evaluated an in vitro model of the follicle-associated epithelia that overlie Peyer's patches of the small intestine. The model shares many phenotypic characteristics of M cells in vivo. Co-cultures of the human adenocarcinoma cell line Caco-2 and freshly isolated Peyer's patch cells were established. F...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02631-1

    authors： Tyrer P,Ruth Foxwell A,Kyd J,Harvey M,Sizer P,Cripps A

    更新日期：2002-12-06 00:00:00

  • PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle disease virus.

    abstract：:Virus infection triggers innate responses to host cells including production of type I interferon (IFN). Since IFN production is also induced by treatment with poly(I:C), viral double-stranded (ds) RNA has been postulated to play a direct role in the process. In the present study, we investigated the effect of dsRNA b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4606

    authors： Iwamura T,Yoneyama M,Koizumi N,Okabe Y,Namiki H,Samuel CE,Fujita T

    更新日期：2001-03-30 00:00:00

  • A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes.

    abstract：:Cardiac ryanodine receptor gene (RyR2) mutations cause fatal arrhythmogenic diseases such as catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right ventricular cardiomyopathy. The N-terminal region of RyR2 is one of the hot spots for mutations. In this study, we investigated cardiac phenotypes ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.08.132

    authors： Okudaira N,Kuwahara M,Hirata Y,Oku Y,Nishio H

    更新日期：2014-09-26 00:00:00

  • A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R.

    abstract：:Evidence exists that the adenosine receptor A(2A)R and the dopamine receptor D(2)R form constitutive heteromers in living cells. Mass spectrometry and pull-down data showed that an arginine-rich domain of the D(2)R third intracellular loop binds via electrostatic interactions to a specific motif of the A(2A)R C-termin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.02.168

    authors： Borroto-Escuela DO,Marcellino D,Narvaez M,Flajolet M,Heintz N,Agnati L,Ciruela F,Fuxe K

    更新日期：2010-03-26 00:00:00

  • The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression.

    abstract：:Interleukin (IL)-18 bioactivity and dsRNA sensing by receptors of innate immunity are key components of anti-viral host defense. Despite extensive data on signal transduction activated by both pathways knowledge on cross-communication is incomplete. By using human PBMC and predendritic KG1 cells, as prototypic IL-18-r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.09.040

    authors： Balah A,Akool el-S,Bachmann M,Pfeilschifter J,Mühl H

    更新日期：2009-11-27 00:00:00

  • Magnetic characterization of Daphnia resting eggs.

    abstract：:This study characterized the magnetic materials found within Daphnia resting eggs by measuring static magnetization with a superconducting quantum interference device (SQUID) magnetometer, after forming two types of conditions, each of which consists of zero-field cooling (ZFC) and field cooling (FC). Magnetic ions, s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.078

    authors： Sakata M,Kawasaki T,Shibue T,Takada A,Yoshimura H,Namiki H

    更新日期：2006-12-15 00:00:00

  • Unusual adult-onset Leigh syndrome presentation due to the mitochondrial m.9176T>C mutation.

    abstract：:Leigh syndrome (LS) is an incurable, nearly always fatal, neurodegenerative, pediatric disorder that results from respiratory chain failure. The most common mitochondrial DNA (mtDNA) mutations that result in LS are m.8993T→C/G and m.9176T→C/G, which were previously found in several patients with early-onset Leigh synd...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.07.076

    authors： Ronchi D,Bordoni A,Cosi A,Rizzuti M,Fassone E,Di Fonzo A,Servida M,Sciacco M,Collotta M,Ronzoni M,Lucchini V,Mattioli M,Moggio M,Bresolin N,Corti S,Comi GP

    更新日期：2011-08-26 00:00:00

  • 6-sulfooxymethylbenzo[a]pyrene is an ultimate electrophilic and carcinogenic form of the intermediary metabolite 6-hydroxymethylbenzo[a]pyrene.

    abstract：:Previous experiments have demonstrated that the intermediary metabolite 6-hydroxymethylbenzo[a] pyrene (HMBP) can be activated to the electrophilic mutagen, 6-sulfooxymethylbenzo[a]pyrene (SMBP), by rat and mouse liver PAPS-dependent sulfotransferase activity or by chemical synthesis. This aralkylating metabolite and ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6679

    authors： Flesher JW,Horn J,Lehner AF

    更新日期：1997-05-29 00:00:00

  • alpha-Difluoromethylornithine does not bind to ornithine decarboxylase-antizyme complex.

    abstract：:alpha-Difluoromethylornithine (DFMO) has been widely used for determining the amounts of ornithine decarboxylase (ODC) in cells. However, we have now found that DFMO does not react with ODC-antizyme complex, indicating that the amounts of radioactive DFMO bound to the protein may not reflect the amounts of ODC in crud...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90338-4

    authors： Kitani T,Fujisawa H

    更新日期：1986-06-30 00:00:00

  • Smad3 contributes to positioning of proliferating cells in colonic crypts by inducing EphB receptor protein expression.

    abstract：:Deficiency of Smad3, an intracellular mediator of TGF-β, was shown to significantly accelerate re-epithelialization of the colonic mucosa. This study was performed to investigate the molecular mechanisms by which Smad3 controls colonic epithelial cell proliferation and crypt formation. Smad3(ex8/ex8) C57BL/6 mice were...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.01.045

    authors： Furukawa K,Sato T,Katsuno T,Nakagawa T,Noguchi Y,Tokumasa A,Yokote K,Yokosuka O,Saito Y

    更新日期：2011-02-25 00:00:00

  • Anticancer, antibacterial and pollutant degradation potential of silver nanoparticles from Hyphaene thebaica.

    abstract：:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.136

    authors： Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SB

    更新日期：2017-08-26 00:00:00

  • MT1-MMP prevents growth inhibition by three dimensional fibronectin matrix.

    abstract：:The extracellular microenvironment plays a key role in regulation of cellular functions and growth control. We show here that membrane-type 1 matrix metalloproteinase (MT1-MMP) acts as a growth promoter in confluent culture. When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.05.134

    authors： Takino T,Guo L,Domoto T,Sato H

    更新日期：2013-07-05 00:00:00

  • Appearance of membrane-bound tyrosine kinase during differentiation of HL-60 leukemia cells by immune interferon and tumor necrosis factor.

    abstract：:The effect of immune interferon (IFN-gamma) and recombinant tumor necrosis factor (rTNF-alpha) on cellular differentiation was investigated in human promyelocytic leukemia cell line HL-60. Both IFN-gamma and rTNF-alpha induced the appearance of the monocytic phenotype in a dose- and time-dependent manner as assessed b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90721-7

    authors： Glazer RI,Chapekar MS,Hartman KD,Knode MC

    更新日期：1986-11-14 00:00:00

  • Transport characteristics of 5-aminosalicylic acid into colonic epithelium: Involvement of sodium-coupled monocarboxylate transporter SMCT1-mediated transport system.

    abstract：:5-Aminosalicylic acid (5-ASA) is conventionally used as a first line drug for inflammatory bowel disease (IBD). Because 5-ASA is well absorbed in the small intestine, very high dose of 5-ASA is required to deliver it to the large intestine which is a target site. Interestingly, 5-ASA is reported to be transported into...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.139

    authors： Yuri T,Kono Y,Fujita T

    更新日期：2020-04-09 00:00:00

  • Activation of bovine photoreceptor guanylate cyclase by S100 proteins.

    abstract：:S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0043

    authors： Margulis A,Pozdnyakov N,Sitaramayya A

    更新日期：1996-01-05 00:00:00

  • Cell cycle synchronization of embryonic stem cells: effect of serum deprivation on the differentiation of embryonic bodies in vitro.

    abstract：:Research on stem-cell transplantation has indicated that the success of transplantation largely depends on synchronizing donor cells into the G0/G1 phase. In this study, we investigated the profile of embryonic stem (ES) cell synchronization and its effect on the formation of embryonic bodies (EBs) using cell culture ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.05.200

    authors： Zhang E,Li X,Zhang S,Chen L,Zheng X

    更新日期：2005-08-12 00:00:00

  • Induction of ornithine decarboxylase activity in mouse tissues by phorbol ester is effectively blocked by methylglyoxal bis(butylamidinohydrazone).

    abstract：:Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection. The increase of ODC activity was due to the enhanced syntheses of mRNA and protein. The inducti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80029-3

    authors： Hibasami H,Tsukada T,Maekawa S,Sakurai M,Nakashima K

    更新日期：1987-04-29 00:00:00

  • Full active baculovirus-expressed human monocyte chemoattractant protein 1 with the intact N-terminus.

    abstract：:The Sf-9 insect cells infected with a recombinant baculovirus integrated with a cDNA encoding human monocyte chemoattractant protein-1 (MCP-1) produced three different MCP-1s, which were isolated by reverse-phase HPLC as 13kDa, 14kDa, and 15kDa bands on SDS-PAGE. The heterogeneity between these MCP-1s was ascribed to ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1135

    authors： Ishii K,Yamagami S,Tanaka H,Motoki M,Suwa Y,Endo N

    更新日期：1995-01-26 00:00:00

  • Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection.

    abstract：:HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc(scid)IL2rg(tm1Wjl)/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently red...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.01.137

    authors： Dubrovsky L,Van Duyne R,Senina S,Guendel I,Pushkarsky T,Sviridov D,Kashanchi F,Bukrinsky M

    更新日期：2012-03-02 00:00:00

  • Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.

    abstract：:Insulin receptor substrates (IRSs) are phosphorylated by activated insulin/insulin-like growth factor (IGF)-I receptor tyrosine kinases. Phosphotyrosyl IRSs are recognized by signaling molecules possessing src homology region 2 (SH2) domains, which mediate various insulin/IGF bioactivities. However, we have shown that...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.12.045

    authors： Fukushima T,Arai T,Ariga-Nedachi M,Okajima H,Ooi Y,Iijima Y,Sone M,Cho Y,Ando Y,Kasahara K,Ozoe A,Yoshihara H,Chida K,Okada S,Kopchick JJ,Asano T,Hakuno F,Takahashi S

    更新日期：2011-01-21 00:00:00

  • Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes.

    abstract：:Phenobarbital (PB) increases metabolic capability of hepatocytes by its ability to activate numerous genes encoding various xenochemical-metabolizing enzymes such as cytochrome P450s and specific transferases. More than 35 years since PB induction was first reported, the key nuclear receptor CAR that mediates the indu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1006/bbrc.2000.3557

    authors： Zelko I,Negishi M

    更新日期：2000-10-14 00:00:00

  • The hemolytic activity of homocysteine is increased by the activated polymorphonuclear leukocytes.

    abstract：:Homocysteine is an accepted risk factor when its plasma level exceeds the physiological upper limit of 12 mumol/L. We found in vitro that homocysteine is able to lyse the erythrocytes (RBCs) at higher concentrations than 15 mumol/L only when activated polymorphonuclear leukocytes (PMNL) are present. The hemolytic effe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1449

    authors： Olinescu R,Kummerow FA,Handler B,Fleischer L

    更新日期：1996-09-24 00:00:00

  • Evidence for the involvement of tryptophan 38 in the active site of glutathione S-transferase P.

    abstract：:Glutathione S-transferase P (GST-P) exists as a homodimeric form and has two tryptophan residues, Trp28 and Trp38, in each subunit. In order to elucidate the role of the two tryptophan residues in catalytic function, we examined intrinsic fluorescence of tryptophan residues and effect of chemical modification by N-bro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91735-9

    authors： Nishihira J,Ishibashi T,Sakai M,Nishi S,Kumazaki T

    更新日期：1992-06-30 00:00:00

  • Activation and deactivation of aflatoxin B1 in isolated rat hepatocytes.

    abstract：:Isolated rat hepatocytes took up [3H]-aflatoxin B1 during incubation with fifty percent of the aflatoxin B1 covalantly bound to cellular macromolecules. The amount of bound-aflatoxin B1 was proportional to the medium concentration of aflatoxin B1. The specific radioactivity (pmole/mg) of aflatoxin B1 found in the DNA ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91201-9

    authors： Ch'ih JJ,Lin T,Devlin TM

    更新日期：1983-01-27 00:00:00

  • A novel iron responsive element in the 3'UTR of human MRCKalpha.

    abstract：:Human untranslated region (UTR) databases were searched to identify novel proteins potentially regulated by an iron responsive element (IRE), and found two candidates-cell cycle phosphatase Cdc14A variant 1 and myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCKalpha), both possessing a putative IRE in ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.155

    authors： Cmejla R,Petrak J,Cmejlova J

    更新日期：2006-03-03 00:00:00

  • Simultaneous detection of native and luminol-dependent luminescence of stimulated human polymorphonuclear leukocytes.

    abstract：:A method for investigating the cellular response of polymorphonuclear leukocytes to various stimuli was introduced using simultaneously native (luminol-independent) and luminol dependent luminescence as an indicator for myeloperoxidase (MPO)-H2O2-halide and O2- mediated reactions. In experimental systems containing lo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80239-9

    authors： Roschger P,Graninger W,Klima H

    更新日期：1984-09-28 00:00:00

  • ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line.

    abstract：:Endemic Alkanna cappadocica was used to isolate novel antitumor molecules from Turkish landscapes in our previous studies. In this study, deoxyalkannin (ALCAP1), β,β-dimethylacrylalkannin (ALCAP2), acetylalkannin (ALCAP3), and alkannin (ALCAP4) as well as the novel isolated compounds 5-methoxydeoxyalkannin (ALCAP5), 8...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.078

    authors： Bogurcu N,Sevimli-Gur C,Ozmen B,Bedir E,Korkmaz KS

    更新日期：2011-06-17 00:00:00

  • Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V.

    abstract：:The cause of hyperpigmentation, such as solar lentigo and seborrheic keratosis, is the excessive accumulation of melanin pigments in the epidermal basal layer. Melanin pigments are synthesized in the melanosomes, which are specific organelles produced by melanocytes in the basal layer. Melanosomes containing melanin p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.070

    authors： Homma T,Kageyama S,Nishikawa A,Nagata K

    更新日期：2018-06-02 00:00:00

  • Stimulation of Mn-superoxide dismutase expression by tumor necrosis factor-alpha: quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA.

    abstract：:Marked increase in protein levels of Mn-superoxide dismutase (Mn-SOD) was found in TNF-resistant cell lines after treatment with Tumor Necrosis Factor (TNF). No such increase was observed in Cu,Zn-superoxide dismutase (Cu, Zn-SOD) protein in either TNF-resistant or sensitive cells. These results support the data that ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90838-e

    authors： Kawaguchi T,Takeyasu A,Matsunobu K,Uda T,Ishizawa M,Suzuki K,Nishiura T,Ishikawa M,Taniguchi N

    更新日期：1990-09-28 00:00:00

  • c-myc gene expression in human cells is controlled by glucose.

    abstract：:The c-myc oncogene is implicated in normal growth and differentiation processes. Human cell lines IM9 and HepG2 stably cultured at "low" glucose concentrations (5.5 mM) show c-myc mRNA levels 3-4 times higher than cells cultured at "high" glucose concentrations (25 nM). D-fructose (a metabolizable exose) substitutes f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92719-8

    authors： Briata P,Laurino C,Gherzi R

    更新日期：1989-12-29 00:00:00