MMP-mediated cleavage of beta-dystroglycan in myelin sheath is involved in autoimmune neuritis.

abstract：:Recently, increasing evidences demonstrate that circular RNAs (circRNAs) exert very important functions in the progression of human cancers. However, the functions and molecular mechanism of circ_0067934 in hepatocellular carcinoma (HCC) are largely unknown. In the present study, we found that the expression of circ_0...

journal_title：Biochemical and biophysical research communications

authors： Zhu Q,Lu G,Luo Z,Gui F,Wu J,Zhang D,Ni Y

更新日期：2018-03-04 00:00:00

abstract：:Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein gp130, which associates with the IL-6 receptor alpha chain (IL-6R alpha) in the presence of IL-6. We prepared monoclonal antibodies (mAbs) specific to murine gp130 by immunizing rats and hamsters with a chimeric molecule consisting of the extrac...

journal_title：Biochemical and biophysical research communications

authors： Matsuda T,Hirano T

更新日期：1994-07-15 00:00:00

abstract：:T-type Ca(2+) channels have been implicated in tremorogenesis and motor coordination. The α1 subunit of the Ca(V)3.1 T-type Ca(2+) channel is highly expressed in motor pathways in the brain, but knockout of the Ca(V)3.1 gene (α(1G)(-/-)) per se causes no motor defects in mice. Thus, the role of Ca(V)3.1 channels in mo...

journal_title：Biochemical and biophysical research communications

authors： Chang KY,Park YG,Park HY,Homanics GE,Kim J,Kim D

更新日期：2011-06-24 00:00:00

abstract：:CD40-mediated signals can induce cell aggregation, proliferation and rescue from apoptosis in WEHI231. To define which segment of cytoplasmic domain of CD40 and how signals are involved in those events, we generated mutant CD40 transfectants. We demonstrated the same 10 amino acid segment that could bind to tumor necr...

journal_title：Biochemical and biophysical research communications

authors： Hara T,Murakami M,Maeda H,Hibi M,Uede T

更新日期：1997-04-07 00:00:00

abstract：:Stearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, triglycerides and cholesterol esters. Previously the full-length human skin cDNA was sequenced and the exon and intron...

journal_title：Biochemical and biophysical research communications

authors： Bené H,Lasky D,Ntambi JM

更新日期：2001-06-29 00:00:00

abstract：:BIK, a member of the Bcl-2 family, has been reported to induce cell apoptosis but the underlying mechanisms are not well delineated. We used siRNA targeting caspase-12 to examine the effect of caspase-12 on apoptosis induced by BIK. In this study, we show that caspase-12 was activated by BIK. With caspase-12 knocked d...

journal_title：Biochemical and biophysical research communications

authors： Zhao X,Sun Y,Yu H,Ye L,Zhang L,Lu J,Yuan Y,Qian G,Ge S

更新日期：2007-08-10 00:00:00

abstract：:Production of endothelin-1 in the cultured neonatal rat cardiac myocytes was investigated. Studies on the cultured cardiac myocytes with reverse transcription-polymerase chain reaction followed by Southern hybridization indicated that mRNA of ET-1(preproET-1 mRNA) was expressed by cardiac myocytes. ET-1 polypeptide wa...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Kumazaki T,Mitsui Y

更新日期：1993-03-31 00:00:00

abstract：:One of the major roles of brain-derived neurotrophic factor (BDNF) is to promote the differentiation and support the survival of neurons in the central nervous system. The objective of the present study was to evaluate the effect of BDNF on the fate of adult rat hippocampus-derived neural stem cells (AHPCs) transplant...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Ooto S,Akagi T,Amemiya K,Igarashi R,Mizushima Y,Takahashi M

更新日期：2003-10-03 00:00:00

abstract：:We have studied the functional properties of an alternately spliced form of sheep testicular FSH receptor cDNA that codes for a protein similar to a previously described active receptor but differs in the carboxy terminus in sequence and is also shorter by 25 residues. The receptor expressed in HEK 293 cells fails to ...

journal_title：Biochemical and biophysical research communications

authors： Sairam MR,Jiang LG,Yarney TA,Khan H

更新日期：1996-09-24 00:00:00

abstract：:The effect of eicosapentaenoic acid (EPA) on natural killer (NK) cell activity of human lymphocytes was examined. The addition of an emulsion of trieicosapentaenoyl-glycerol (EPA-TG) emulsified with purified phosphatidylcholine from krill to a cytotoxicity assay system resulted in a marked depression of NK activity. T...

journal_title：Biochemical and biophysical research communications

authors： Yamashita N,Yokoyama A,Hamazaki T,Yano S

更新日期：1986-08-14 00:00:00

abstract：:Rbx1 and Rbx2 are essential components of Cullin-RING E3 Ligases. Vif is generally believed to preferentially recruit the Cul5-Rbx2 module to induce proteasomal degradation of antiretroviral enzyme APOBEC3G, although some investigators have found that the Cul5-Rbx1 module is recruited. Here, to investigate the functio...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Wang X,Wang W,Zhang J,Wang J,Wang C,Lv M,Zuo T,Liu D,Zhang H,Wu J,Yu B,Kong W,Wu H,Yu X

更新日期：2015-06-12 00:00:00

abstract：:In some v-Ha-ras-transfected cell lines, serum deprivation results in apoptosis. Clarification of the molecular mechanisms by which oncogenic Ras controls susceptibility to apoptosis may assist in the development of effective therapies against human cancer with oncogenic ras gene. In this report, we established a v-Ha...

journal_title：Biochemical and biophysical research communications

authors： Arase Y,Hiwasa T,Hasegawa R,Nomura J,Ito H,Suzuki N

更新日期：2000-01-07 00:00:00

abstract：:Seven monoclonal antibodies to low-density lipoprotein were studied by the ELISA for their reactivity with LDL or VLDL. Cotitration experiments showed that five of them are addressed to different antigenic epitopes. Two of the monoclonal antibodies were temperature independent whereas the others had a decreased bindin...

journal_title：Biochemical and biophysical research communications

authors： Salmon S,Goldstein S,Pastier D,Theron L,Berthelier M,Ayrault-Jarrier M,Dubarry M,Rebourcet R,Pau B

更新日期：1984-12-14 00:00:00

abstract：:The formation of nitric oxide in biological systems has led to the discovery of a number of post-translational protein modifications that could regulate protein function or potentially be utilized as transducers of nitric oxide signaling. Principal among the nitric oxide-mediated protein modifications are: the nitric ...

journal_title：Biochemical and biophysical research communications

authors： Ischiropoulos H

更新日期：2003-06-06 00:00:00

abstract：:Due to their identical inheritance and shared surroundings, identical twins have been the recommended group for studying the susceptibility and prognosis of diseases. Here, CD8+ T cell receptor beta (TCRβ) chains were analyzed by high-throughput sequencing in three pairs of healthy identical twins and chronic hepatiti...

journal_title：Biochemical and biophysical research communications

authors： Jiang Q,Liu Y,Xu B,Zheng W,Xiang X,Tang X,Dong H,Chen Y,Wang C,Deng G,Mao Q,Shang X,Wu Y

更新日期：2018-02-26 00:00:00

abstract：:We have deduced the exon structure of the 5' untranslated region of the human cardiac alpha-myosin heavy chain gene by cloning a cDNA for this region using the polymerase chain reaction. Comparison of the cDNA and genomic DNA sequences demonstrates that the 5' non-coding region of the alpha-myosin heavy chain gene is ...

journal_title：Biochemical and biophysical research communications

authors： Brand NJ,Dabhade N,Yacoub M,Barton PJ

更新日期：1991-09-30 00:00:00

abstract：:Aging is associated with extensive cognitive impairments, although the biochemical and physiological basis of these deficits are unknown. As the hippocampus plays a vital role in cognitive functions, we have selected this tissue to analyze changes in gene expression at two different ages. Array technology is utilized ...

journal_title：Biochemical and biophysical research communications

authors： Kumar VB,Franko MW,Farr SA,Armbrecht HJ,Morley JE

更新日期：2000-06-16 00:00:00

abstract：:Wnt/beta-catenin signaling plays an important role not only in cancer, but also in cancer stem cells. In this study, we found that beta-catenin and OCT-4 was highly expressed in cisplatin (DDP) selected A549 cells. Stimulating A549 cells with lithium chloride (LiCl) resulted in accumulation of beta-catenin and up-regu...

journal_title：Biochemical and biophysical research communications

authors： Teng Y,Wang X,Wang Y,Ma D

更新日期：2010-02-12 00:00:00

abstract：:A 5T/6T polymorphism in the human MMP-3 promoter affects gene expression and impacts the risk and/or severity of various pathological conditions. Chromatin immunoprecipitation (ChIP) in human fibroblasts homozygous for the 6T site demonstrate that it is bound by NF-kappaB and ZBP-89 transcription factors in its native...

journal_title：Biochemical and biophysical research communications

authors： Borghaei RC,Gorski G,Javadi M,Mariah Chambers.

更新日期：2009-05-01 00:00:00

abstract：:The synthetic (1-->6)-alpha-D-glucopyranan with branching and without branching were tested as a new hypoglycaemic drug. (1-->6)-alpha-D-glucopyranan having an alpha-D-glucopyranosyl branch at the C-3 position (1) showed a remarkable hypoglycaemic activity on i.p. injection to mice. The polysaccharide having both alph...

journal_title：Biochemical and biophysical research communications

authors： Hatanaka K,Song SC,Maruyama A,Kobayashi A,Kuzuhara H,Akaike T

更新日期：1992-10-15 00:00:00

abstract：:The ferromagnetic transduction model proposed by J.L. Kirschvink (Phys. Rev. A (1992) 46, 2178-2184) suggests that the coupling of biogenic magnetic particles in the human brain to mechanosensitive membrane ion gates may provide a mechanism for interactions of environmental magnetic fields with humans. Extremely low f...

journal_title：Biochemical and biophysical research communications

authors： Dobson J,St Pierre T

更新日期：1996-10-23 00:00:00

abstract：:Ubiquitous calpains (calpain I and II) are generally recognized as cytosolic proteins. Recently, mitochondrial localized calpain I (μ-calpain) has been identified. Activation of mito-μ-calpain cleaves apoptosis inducing factor (AIF), a flavoprotein located within the mitochondrial intermembrane space, in liver mitocho...

journal_title：Biochemical and biophysical research communications

authors： Chen Q,Paillard M,Gomez L,Ross T,Hu Y,Xu A,Lesnefsky EJ

更新日期：2011-12-02 00:00:00

abstract：:The calcium-sensing receptor (CaSR) was cloned initially from the bovine parathyroid and its primary physiological role is maintaining constant blood Ca(2+) levels. Subsequently, CaSR was found to be expressed in human adipose tissue, however, its physiological functions remain unclear. In this study, the effect of Ca...

journal_title：Biochemical and biophysical research communications

authors： He Y,Zhang H,Teng J,Huang L,Li Y,Sun C

更新日期：2011-01-07 00:00:00

abstract：:In mammals dietary ferric iron is reduced to ferrous iron for more efficient absorption by the intestine. Analysis of a pig duodenal membrane fraction revealed two NADH-dependent ferric reductase activities, one associated with a b-type cytochrome and the other not. Purification and characterization of the non-cytochr...

journal_title：Biochemical and biophysical research communications

authors： Lee PL,Halloran C,Cross AR,Beutler E

更新日期：2000-05-19 00:00:00

abstract：:Here we present a simple and highly reproducible method which allows the study of the effects of a single gene knockdown in an organotypic skin model. Human keratinocytes (KC) were transfected with backbone-modified short interfering RNAs (siRNAs) specific for vascular endothelial growth factor (VEGF) and matriptase-1...

journal_title：Biochemical and biophysical research communications

authors： Mildner M,Ballaun C,Stichenwirth M,Bauer R,Gmeiner R,Buchberger M,Mlitz V,Tschachler E

更新日期：2006-09-15 00:00:00

abstract：:A polyamine derivative, carboxyethyl - Aminobutyric Acid (CEGABA), induces the formation of a large number of Epstein-Barr Virus (EBV) transformed lymphocytes, when added to the culture medium immediately after EBV infection. However, CEGABA shows only a moderate effect on the stability of EBV-transformed cell lines o...

journal_title：Biochemical and biophysical research communications

authors： Cerino A,Bestagno M,Colonna M,Fussi F,Astaldi Ricotti GC

更新日期：1988-02-15 00:00:00

abstract：:FamD1 is a novel CloQ/NphB-family indole prenyltransferase which involves in hapalindole-type alkaloid biosynthesis. Here the native FamD1 structure and three protein-ligand complexes are analyzed to investigate the molecular basis of substrate binding and catalysis. FamD1 adopts a typical ABBA architecture of aromati...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Chen CC,Yang Y,Liu W,Ko TP,Shang N,Hu X,Xie Y,Huang JW,Zhang Y,Guo RT

更新日期：2018-01-08 00:00:00

abstract：:Phosphorylation of a 25 Kdalton nuclear stress protein from rat muscle was examined by two-dimensional gel electrophoresis and one-dimensional peptide mapping. These studies show that three 25 Kdalton stress proteins found in stressed rat myoblasts are actually the same protein with charge variation brought about by m...

journal_title：Biochemical and biophysical research communications

authors： Kim YJ,Shuman J,Sette M,Przybyla A

更新日期：1983-12-28 00:00:00

abstract：:The cytochrome P-450 catalyzing 26-hydroxylation of C27-steroids (cytochrome P-450(26] was purified from rabbit liver mitochondria. The specific content of the cytochrome P-450 was 13.6 nmol per mg of protein and the 26-hydroxylase activity towards 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol was 31,300 pmol/nmo...

journal_title：Biochemical and biophysical research communications

authors： Dahlbäck H

更新日期：1988-11-30 00:00:00

abstract：:The late endosomal marker Rab7 has been long believed to be absent from the phagosome containing Mycobacterium tuberculosis (M.tb) in macrophage, but the detail kinetics remains elusive. Here, we found that Rab7 is transiently recruited to and subsequently released from M.tb phagosomes. For further understanding of th...

journal_title：Biochemical and biophysical research communications

authors： Seto S,Matsumoto S,Ohta I,Tsujimura K,Koide Y

更新日期：2009-09-18 00:00:00