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Endothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitro.

Abstract：

:Production of endothelin-1 in the cultured neonatal rat cardiac myocytes was investigated. Studies on the cultured cardiac myocytes with reverse transcription-polymerase chain reaction followed by Southern hybridization indicated that mRNA of ET-1(preproET-1 mRNA) was expressed by cardiac myocytes. ET-1 polypeptide was also detected in the cultured cardiac myocytes. Moreover, ET-1 was secreted into the culture medium by them. These results suggest that the cardiac myocytes, which have been regarded as target cells of ET-1, are able to synthesize and secrete ET-1. Furthermore, there may be a possible autocrine mechanism of ET-1 in the myocytes of a heart.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suzuki T,Kumazaki T,Mitsui Y

doi

10.1006/bbrc.1993.1291

subject

Has Abstract

pub_date

1993-03-31 00:00:00

pages

823-30

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71291-X

journal_volume

191

pub_type

杂志文章

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