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Dissection of Rab7 localization on Mycobacterium tuberculosis phagosome.

Abstract：

:The late endosomal marker Rab7 has been long believed to be absent from the phagosome containing Mycobacterium tuberculosis (M.tb) in macrophage, but the detail kinetics remains elusive. Here, we found that Rab7 is transiently recruited to and subsequently released from M.tb phagosomes. For further understanding of the effect of Rab7 dissociation from the phagosome, we examined the localization of lysosomal markers on the phagosome in the macrophage expressing a dominant-negative Rab7. The localization of lysosomal associated membrane protein-2 (LAMP-2) on the phagosome was Rab7-independent, while that of cathepsin D was Rab7-dependent. These results agree with the localization of each lysosomal marker on M.tb phagosome at 6h postinfection-i.e., LAMP-2, but not cathepsin D localized on the majority of M.tb phagosomes. These results suggest that the dissociation of Rab7 from M.tb phagosome is the important process in inhibition of phagolysosome biogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Seto S,Matsumoto S,Ohta I,Tsujimura K,Koide Y

doi

10.1016/j.bbrc.2009.06.152

subject

Has Abstract

pub_date

2009-09-18 00:00:00

pages

272-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01323-0

journal_volume

387

pub_type

杂志文章

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