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Differentiation-dependent regulation of skeletal myogenesis by neuregulin-1.

Abstract：

:Neuregulins comprise a group of growth factor proteins that regulate the differentiation of skeletal muscle. Here, we report that neuregulins are regulators of myogenic differentiation and stimulate mitogenesis in L6 skeletal myoblasts. The mitogenic response to neuregulin-1 was differentiation-dependent and observed only in aligned, differentiating cells. Treatment of these cells with neuregulin-1 increased [3H]thymidine incorporation and cell proliferation by 2- to 5-fold, while a minimal increase was seen in proliferating myoblasts. Neuregulin-1 did not induce DNA synthesis in fused, multinucleated myotubes. The increased DNA synthesis correlated with downregulation of myogenin and inhibition of myoblast fusion and myotube formation. These data suggest that neuregulins may regulate skeletal myogenesis in vivo and that this regulation is dependent on the state of differentiation of the myocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ford BD,Han B,Fischbach GD

doi

10.1016/s0006-291x(03)00964-1

subject

Has Abstract

pub_date

2003-06-20 00:00:00

pages

276-81

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X03009641

journal_volume

306

pub_type

杂志文章

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