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Are hypothalamic neurons transsynaptically connected to porcine adipose tissue?

Abstract：

:Specific anatomical sites and pathways responsible for mediating metabolic and neuroendocrine effects of leptin are still poorly understood. Therefore, we examined distribution of leptin receptor-containing neurons transsynaptically connected with the porcine fat tissue by means of combined viral transneuronal tracing and immunohistochemical staining method. Pseudorabies virus (PRV) was injected into the perirenal fat tissue in pigs, and after survival periods of 3, 5, 7, 9, and 11 days, hypothalami were processed immunohistochemically with primary antisera against PRV and leptin receptor (OBR). PRV labeled neurons were found in paraventricular nucleus (PVN), ventromedial nucleus (VMN), anterior hypothalamic area (AHA), preoptic area (PA), arcuate nucleus (ARC), and supraoptic nucleus (SON) by nine days after injection of the virus. Double-labeling immunofluorescence demonstrated that OBR were co-localized in nearly all virus-infected neurons. The present results provide the first morphological data demonstrating a multisynaptic circuit of neurons of CNS origin which innervates porcine fat tissue.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Czaja K,Kraeling RR,Barb CR

doi

10.1016/j.bbrc.2003.10.026

subject

Has Abstract

pub_date

2003-11-14 00:00:00

pages

482-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X03021065

journal_volume

311

pub_type

杂志文章

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