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Parallel effects of insulin-like growth factor-II and insulin on glucose metabolism of developing mouse embryonic limb buds in culture.

Abstract：

:The present study was undertaken to evaluate the functional significance of the previously observed increase in the level of IGF-II receptors despite the loss of growth promoting activity of IGF-II in differentiated limb buds in organ culture. In the present study IGF-II and insulin at similar concentration (0.1-1 microgram/ml) stimulated the glucose uptake by the tissue and incorporation into glycogen (approximately 2 and 4 times control) and stimulated the activity of glycogen synthase (approximately 2 times control) of the limb buds irrespective of the differentiation stage of the tissues. IGF-I had little or no effect. None of the hormones (IGF-I, II or insulin) had any effect on the CO2 production by the limb buds. These results suggest a regulatory role of IGF-II, complementary or overlapping with insulin, in glucose metabolism of the developing limb buds. The absence of the effects of both IGF-II and insulin on CO2 production by the tissue, however, indicate that the IGF-II and insulin regulation of glucose metabolism of the limb buds is predominantly on glycogen synthesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Bhaumick B,Bala RM

doi

10.1016/s0006-291x(88)80722-8

subject

Has Abstract

pub_date

1988-04-15 00:00:00

pages

359-67

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80722-8

journal_volume

152

pub_type

杂志文章

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