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Identification of a novel collagen chain represented by extensive interruptions in the triple-helical region.

Abstract：

:We have isolated mouse cDNA clones that encode a newly discovered collagenous polypeptide. Four overlapping cDNA clones contained an open reading frame of 1140 amino acid residues of collagenous and non-collagenous domains. The predicted polypeptide consists of 10 collagenous domains of various length that are interrupted by 11 noncollagenous domains. The overall structural arrangement differed significantly from reported collagen chains of 17 different types. Northern-blot analyses showed hybridization of the cDNA to 5.6kb and 4.8kb mRNA species in liver and kidney that are due to utilization of the two poly (A) signals.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Abe N,Muragaki Y,Yoshioka H,Inoue H,Ninomiya Y

doi

10.1006/bbrc.1993.2288

subject

Has Abstract

pub_date

1993-10-29 00:00:00

pages

576-82

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72288-6

journal_volume

196

pub_type

杂志文章

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