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The role of microRNA in the delayed negative feedback regulation of gene expression.

Abstract：

:Oscillatory gene expression plays an important role in somite segmentation during the early developmental stages of vertebrates. Recent experimental studies have shown that microRNA can regulate gene expression by stimulating degradation of mRNA and/or repression of translation. In this communication, we incorporate miRNA into a previous mathematical model of gene expression with delayed negative feedback and demonstrate how this modified model can elucidate the possible effect of miRNA on the oscillatory gene expression. Our finding suggests that miRNA maybe a destabilizing or stabilizing factor in the dynamics of gene expression depending on the severity of its effect on mRNA degradation. Our finding provides testable hypothesis for experimental biologists to further investigate miRNA's increasing functional roles in regulating cellular processes and development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Xie ZR,Yang HT,Liu WC,Hwang MJ

doi

10.1016/j.bbrc.2007.04.207

subject

Has Abstract

pub_date

2007-07-06 00:00:00

pages

722-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00883-2

journal_volume

358

pub_type

杂志文章

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