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Association of the putative B-lymphocyte surface molecule B7.3 with a protein kinase activity.

Abstract：

:Monoclonal antibody BB1 was previously shown to recognize the CD80 protein as well as a putative B7.3 molecule, both ligands of the important T-cell receptors CD28 and CTLA-4. We report that BB1 coprecipitated from detergent lysates of human B- and pre-B-cell lines a protein kinase activity, as detected by solid phase immunoprecipitation followed by in vitro kinase assay. As other monoclonal antibodies to CD80 did not co-precipitate any kinase activity, it seems likely that this protein kinase is associated with the so far poorly characterized putative B7.3 molecule.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Angelisová P,Cerný J,Horejsí V

doi

10.1006/bbrc.1996.1687

subject

Has Abstract

pub_date

1996-11-12 00:00:00

pages

489-93

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X96916873

journal_volume

228

pub_type

杂志文章

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