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The fate of internalized alpha-2-macroglobulin: alpha-galactosidase conjugate in fibroblasts from Fabry's hemizygote.

Abstract：

:In our previous report we described the endocytotic incorporation of coffee bean alpha-galactosidase conjugated to human alpha-2-macroglobulin (alpha-2-M) into cultured fibroblasts derived from a patient with Fabry's disease (1). The fate of internalized alpha-galactosidase according to the method described in the above report is now studied. Measurement of the enzyme activity of subcellular fractions showed that it was concentrated in the lysosomal-mitochondrial fraction. The half-life of internalized alpha-galactosidase was determined to be 2 h.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Osada T,Kuroda Y,Ikai A

doi

10.1016/0006-291x(87)90343-3

subject

Has Abstract

pub_date

1987-03-30 00:00:00

pages

954-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90343-3

journal_volume

143

pub_type

杂志文章

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