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Characterization of a novel human gene containing ANK repeats and ARM domains.

Abstract：

:We report here on characterization of a novel human gene on chromosome 2q32, containing several ankyrin repeats and ARM domains. The gene FLJ25415, including at least 31 exons and spanning about 90kb of a gene-rich genomic region, is present in the human genome as a single copy. It seems highly conserved along the mammalian phylogeny. By analysing FLJ25415 gene expression in different human tissues, we demonstrated a ubiquitously expression pattern with extensive alternative splicing. In silico prediction of promoter regions revealed the presence of a TATA box and some hypothetical transcription factor binding sites, such as TMF, C/EBPalpha, LE-1, and NF-ATp.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Occhi G,Olivieri M,Rampazzo A,Danieli GA

doi

10.1016/j.bbrc.2004.03.186

subject

Has Abstract

pub_date

2004-05-21 00:00:00

pages

38-45

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X04007089

journal_volume

318

pub_type

杂志文章

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