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A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells.

Abstract：

:Precise control of neuronal migration is essential for the development of the neocortex. However, the molecular mechanisms underlying neuronal migration remain largely unknown. Here we identified helix-loop-helix transcription factor Ebf3 as a Prdm8 target gene, and found that Ebf3 is a key regulator of neuronal migration via multipolar-to-bipolar transition. Ebf3 knockdown cells exhibited severe defects in the formation of leading processes and an inhibited shift to the locomotion mode. Moreover, we found that Ebf3 knockdown represses NeuroD1 transcription, and NeuroD1 overexpression partially rescued migration defects in Ebf3 knockdown cells. Our findings highlight the critical role of Ebf3 in multipolar-to-bipolar transition via positive feedback regulation of NeuroD1 in the developing neocortex.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Iwai R,Tabata H,Inoue M,Nomura KI,Okamoto T,Ichihashi M,Nagata KI,Mizutani KI

doi

10.1016/j.bbrc.2017.11.021

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

388-394

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32198-8

journal_volume

495

pub_type

杂志文章

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