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A novel aortic smooth muscle cell line obtained from p53 knock out mice expresses several differentiation characteristics.

Abstract：

:Here we report that we could obtain a highly differentiated smooth muscle cell line by screening the expression of a-smooth muscle actin from p53 knook out mice aorta. This cell revealed extended bipolar shape and expressed h-caldesmon and calponin as well as a-smooth muscle actin as protein markers of differentiated smooth muscle. Further intracellular calcium increase was induced by application of noradrenaline in a dose dependent manner and calcium oscillation was also observed in a higher dose (100 microM). Appropriate application of 5-azacytidine enhanced these tendencies and induced slow contraction by endothelin-1 and phenylephrine.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ohmi K,Masuda T,Yamaguchi H,Sakurai T,Kudo Y,Katsuki M,Nonomura Y

doi

10.1006/bbrc.1997.7218

subject

Has Abstract

pub_date

1997-09-08 00:00:00

pages

154-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97218-1

journal_volume

238

pub_type

杂志文章

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