Effect of phospholipase Cbeta4 lacking in thalamic neurons on electroencephalogram.

abstract：:Mutation in DJ-1 gene is the cause of autosomal recessive Parkinson's disease, however, its physiological function remains unclear. The isoelectric point of DJ-1 shows an acidic shift after cells are treated with hydrogen peroxide. This suggests that DJ-1 is modified in response to oxidative stress. Here we report the...

journal_title：Biochemical and biophysical research communications

authors： Kinumi T,Kimata J,Taira T,Ariga H,Niki E

更新日期：2004-05-07 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Although cytotoxicity of amyloid β peptides has been intensively studied within pathophysiology of AD, the physiological function of amyloid precursor protein (APP) still remains unclarified. We have shown previously tha...

journal_title：Biochemical and biophysical research communications

authors： Kwak YD,Hendrix BJ,Sugaya K

更新日期：2014-05-09 00:00:00

abstract：:We have developed a new and rapid immunofluorescent method for visualisation of replicated regions on fixed DNA fibers. Using this method we have found in 5-fluorodeoxyuridine (FrdU)-blocked human cells distinct replication units covering about 60 kb of DNA and corresponding in size to single replicons or chromatin lo...

journal_title：Biochemical and biophysical research communications

authors： Tomilin N,Rosanov Yu,Zenin V,Bozhkov V,Vig B

更新日期：1993-01-15 00:00:00

abstract：:The effects of substance P on cultured rabbit osteoclasts were investigated. The intracellular Ca(2+) concentration ([Ca(2+)](i)) which was monitored by the microfluorometric technique using fura-2, in osteoclasts elevated by the addition of substance P (0.3-5 microM). The EC(50) value of substance P was about 200 nM....

journal_title：Biochemical and biophysical research communications

authors： Mori T,Ogata T,Okumura H,Shibata T,Nakamura Y,Kataoka K

更新日期：1999-08-27 00:00:00

abstract：:Recently, we reported that Lumbricusin, an antimicrobial peptide isolated from earthworm Lumbricus terrestris, enhanced neuronal proliferation and ameliorated motor dysfunction and dopaminergic neurodegeneration. Accumulating evidence suggests that neurodegeneration is the primary pathological feature of acute or chro...

journal_title：Biochemical and biophysical research communications

authors： Seo M,Lee JH,Baek M,Kim MA,Ahn MY,Kim SH,Yun EY,Hwang JS

更新日期：2017-08-26 00:00:00

abstract：:Several rat liver cytochromes P-450 have been substantially purified in a one-step immunoadsorption procedure using Sepharose-bound monoclonal antibodies (MAbs) to the major forms of rat liver cytochrome P-450 induced by 3-methylcholanthrene and phenobarbital (MC-P-450 and PB-P-450, respectively). When mixed with solu...

journal_title：Biochemical and biophysical research communications

authors： Friedman FK,Robinson RC,Park SS,Gelboin HV

更新日期：1983-11-15 00:00:00

abstract：:Migration of surviving kidney tubule cells after sub-lethal injury, for example ischemia/reperfusion (I/R), plays a critical role in recovery. Exocytosis is known to be involved in cell migration, and a key component in exocytosis is the highly-conserved eight-protein exocyst complex. We investigated the expression of...

journal_title：Biochemical and biophysical research communications

authors： Noh MR,Jang HS,Song DK,Lee SR,Lipschutz JH,Park KM,Kim JI

更新日期：2018-02-05 00:00:00

abstract：:Diphenyleneiodonium (DPI) and N-acetyl-l-cysteine (NAC), two widely used anti-oxidants, were employed to evaluate the role of oxidative stress in Japanese encephalitis virus (JEV) induced autophagy, stress responses and replication. DPI and NAC exerted opposite effects on ROS levels in JEV infected mouse neuronal cell...

journal_title：Biochemical and biophysical research communications

authors： Sharma M,Sharma KB,Chauhan S,Bhattacharyya S,Vrati S,Kalia M

更新日期：2018-07-12 00:00:00

abstract：:TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal linea...

journal_title：Biochemical and biophysical research communications

authors： Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

更新日期：2007-01-26 00:00:00

abstract：:It has been suggested that epigenetic regulation plays an important role in maintaining the stemness and lineage differentiation of hematopoietic stem cells (HSCs), 5-aza-deoxycytidine (aza-D) and Trichostatin A (TSA) being candidate additives for HSC ex vivo expansion. Although they have potent activity to maintain t...

journal_title：Biochemical and biophysical research communications

authors： Koh SH,Choi HS,Park ES,Kang HJ,Ahn HS,Shin HY

更新日期：2005-04-15 00:00:00

abstract：:Thioredoxin (TRX) is one of major components of thiol reducing systems. To investigate the molecular mechanism of TRX function in the lung tissue, we screened a human lung epithelial cell cDNA library for TRX-binding protein by yeast two-hybrid systems. We isolated a plasmid containing C-propeptide region of human pro...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Masutani H,Nishiyama A,Hashimoto S,Gon Y,Horie T,Yodoi J

更新日期：2002-07-19 00:00:00

abstract：:Single particle tracking (SPT) is a powerful technique for studying mRNA dynamics in cells. Although SPT of mRNA has been performed by labeling mRNA with fluorescent dyes or proteins, observation of mRNA for long durations with high temporal resolution has been difficult due to weak fluorescence and rapid photobleachi...

journal_title：Biochemical and biophysical research communications

authors： Ishihama Y,Funatsu T

更新日期：2009-03-27 00:00:00

abstract：:Understanding the pathogenesis of infectious diseases requires comprehensive knowledge of the proteins expressed by the pathogen during in vivo growth in the host. Proteomics provides the tools for such analyses but the protocols required to purify sufficient quantities of the pathogen from the host organism are curre...

journal_title：Biochemical and biophysical research communications

authors： Twine SM,Mykytczuk NC,Petit MD,Shen H,Sjöstedt A,Wayne Conlan J,Kelly JF

更新日期：2006-07-14 00:00:00

abstract：:The wound healing process is initiated as soon as tissue is injured. Herein, we demonstrate that c-fos and c-myc mRNA transcripts are promptly increased in the wounded tissue in vivo and in vitro. A buffer solution from scraped serum-starved quiescent fibroblasts, when added to resting fibroblasts, caused the increase...

journal_title：Biochemical and biophysical research communications

authors： Tsuboi K,Yamaoka S,Maki M,Ohshio G,Tobe T,Hatanaka M

更新日期：1990-05-16 00:00:00

abstract：:With age human collagen demonstrates, amongst other changes, reductions in solubility, elasticity and permeability. Many of these changes have been attributed to non-enzymic glycosylation (glycation)-a spontaneous addition of sugar molecules to any protein with free amino groups. The resulting formation and accumulati...

journal_title：Biochemical and biophysical research communications

authors： Malik NS,Meek KM

更新日期：1994-03-15 00:00:00

abstract：:Sma- and MAD-related protein 3 (Smad3) plays crucial roles in the transforming growth factor-beta (TGF-beta)-mediated signaling pathway, which produce a variety of cellular responses, including cell proliferation and differentiation. In our previous study, we demonstrated that protein inhibitor of activated STATy (PIA...

journal_title：Biochemical and biophysical research communications

authors： Imoto S,Ohbayashi N,Ikeda O,Kamitani S,Muromoto R,Sekine Y,Matsuda T

更新日期：2008-05-30 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders and is characterized by impaired attention, hyperactivity, and impulsivity. While multiple etiologies are implicated in ADHD, its underlying mechanism(s) remain unclear. Although previous studies have suggested dysre...

journal_title：Biochemical and biophysical research communications

authors： Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

更新日期：2019-06-11 00:00:00

abstract：:The mechanisms underlying diabetes-mediated bone loss are not well defined. It has been reported that the advanced glycation endproducts (AGEs) and receptor for AGEs (RAGEs) are involved in diabetic complications. Here, mice deficient in RAGE were used as a model for investigating the effects of RAGE on bone mass. We ...

journal_title：Biochemical and biophysical research communications

authors： Ding KH,Wang ZZ,Hamrick MW,Deng ZB,Zhou L,Kang B,Yan SL,She JX,Stern DM,Isales CM,Mi QS

更新日期：2006-02-24 00:00:00

abstract：:To investigate pathophysiological roles of endothelin-1 (ET-1) in collagen remodeling in pulmonary hypertension, we measured: (a) mRNA expression, concentration, localization of ET-1; (b) changes in types and content of collagen in the lung; (c) and confirmed direct effects of ET-1 on type V collagen metabolism in vas...

journal_title：Biochemical and biophysical research communications

authors： Mansoor AM,Honda M,Saida K,Ishinaga Y,Kuramochi T,Maeda A,Takabatake T,Mitsui Y

更新日期：1995-10-24 00:00:00

abstract：:Development of Grb2-SH2 domain antagonists is considered to be an effective and non-cytotoxic strategy to develop new antiproliferative agents because of their potential to shut down the Ras signaling pathway. We developed a concise route for the efficient synthesis of G1TE analogs on solid phase. Using this route, a ...

journal_title：Biochemical and biophysical research communications

authors： Jiang S,Li P,Peach ML,Bindu L,Worthy KW,Fisher RJ,Burke TR Jr,Nicklaus M,Roller PP

更新日期：2006-10-20 00:00:00

abstract：:Biological membranes are composed of functionally relevant liquid-ordered and liquid-disordered domains that coexist. Within the liquid-ordered domains are low-density microdomains known as rafts with a unique lipid composition that is crucial for their structure and function. Lipid raft composition is altered in sphi...

journal_title：Biochemical and biophysical research communications

authors： Hattersley KJ,Hein LK,Fuller M

更新日期：2013-12-06 00:00:00

abstract：:Bile acids of patients with renal failure and of healthy subjects were analyzed by capillary gas chromatography after group separation. The amount of bile acids in the total dialysate (150 L) of the patients was smaller than that in the 24-h urine of healthy subjects. Polar bile acid sulfates constituted 17.3% and 30....

journal_title：Biochemical and biophysical research communications

authors： Yamaga N,Adachi K,Kohara H,Shimizu K

更新日期：1988-04-15 00:00:00

abstract：:NF-kappaB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and survival. The finding that the deletion of both NF-kappaB p50 and p52 subunits resulted in osteopetrosis due to the absence of osteoclasts was followed by the observation that NF-kappaB is essential for RANK-expressing...

journal_title：Biochemical and biophysical research communications

authors： Soysa NS,Alles N

更新日期：2009-01-02 00:00:00

abstract：:Cell motility and cell stiffness are closely related to metastatic activity of cancer cells. (-)-Epigallocatechin gallate (EGCG) has been shown to inhibit spontaneous metastasis of melanoma cell line into the lungs of mice, so we studied the effects of EGCG on cell motility, cell stiffness, and expression of vimentin ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi A,Watanabe T,Mondal A,Suzuki K,Kurusu-Kanno M,Li Z,Yamazaki T,Fujiki H,Suganuma M

更新日期：2014-01-03 00:00:00

abstract：:In many apoptotic cells, phosphatidylserine (PS), that is normally restricted to the inner membrane layer, is externalized and subsequently recognized by phagocytes. However, it has been unclear whether PS externalization is sufficient for phagocytosis induction. In a cultured cell line undergoing Fas-mediated apoptos...

journal_title：Biochemical and biophysical research communications

authors： Shiratsuchi A,Osada S,Kanazawa S,Nakanishi Y

更新日期：1998-05-19 00:00:00

abstract：:To clarify the mechanism of transcriptional induction of the rat liver acyl-CoA oxidase gene by hypolipidemic agents, we searched for cis-acting regulatory sequences in the 5' upstream region of the gene by transfection studies. We found that the sequence between -639 and -472 acts as a peroxisome proliferator-respons...

journal_title：Biochemical and biophysical research communications

authors： Osumi T,Wen JK,Hashimoto T

更新日期：1991-03-29 00:00:00

abstract：:HES-3 is a cerebellar Purkinje cell-specific helix-loop-helix factor structurally related to the products of the Drosophila hairy and Enhancer of split genes. Here, we report the nucleotide sequence and chromosomal locus of the mouse Hes-3 gene. This gene consists of four exons and the exon-intron boundaries are well ...

journal_title：Biochemical and biophysical research communications

authors： Sakagami T,Sakurada K,Sakai Y,Watanabe T,Nakanishi S,Kageyama R

更新日期：1994-08-30 00:00:00

abstract：:p70 S6 kinase (p70 S6k) is important in regulating a variety of cellular functions including mRNA translation and cell cycle progression and is activated by mitogens and hormones. Unexpectedly, we have found that, in adult rat cardiomyocytes, arsenite, which generally induces stress responses, markedly and rapidly act...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Proud CG

更新日期：1997-09-08 00:00:00

abstract：:Recently, we have shown that the thyrotropin (TSH) binding regions of human thyrotropin receptor (TSHR) reside in two areas within residues 12-44 and 308-344. Serial antisera were raised against four overlapping synthetic peptides representing these two regions of TSHR (peptides 12-30, 24-44, 308-328, and 324-344) and...

journal_title：Biochemical and biophysical research communications

authors： Sakata S,Ogawa T,Matsui I,Manshouri T,Atassi MZ

更新日期：1992-02-14 00:00:00

abstract：:Gut microbiota is critical for maintaining body immune homeostasis and thus affects tumor growth and therapeutic efficiency. Here, we investigated the link between microbiota and tumorgenesis in a mice model of subcutaneous melanoma cell transplantation, and explored the underlying mechanism. We found disruption of gu...

journal_title：Biochemical and biophysical research communications

authors： Xu C,Ruan B,Jiang Y,Xue T,Wang Z,Lu H,Wei M,Wang S,Ye Z,Zhai D,Wang L,Lu Z

更新日期：2017-06-24 00:00:00