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Identification of a retina-specific footprint within the retina-specific regulatory region of the human interphotoreceptor retinoid-binding protein gene.

Abstract：

:Regulation of the retina-specific expression of the interphotoreceptor retinoid-binding protein (IRBP) gene in transgenic mice requires sequences between nucleotide (nt) -156 and +19. DNAse I footprinting and electrophoretic mobility shift assays identified a region between nt -69 and -40 that interacts with some nuclear proteins from bovine and mouse retinas but not from a variety of other neural and non-neural tissues. The selectivity of this sequence to elicit IRBP promoter activity is indicated by their failure to bind some nuclear proteins following mutagenesis. Therefore, IRBP promoter activity is linked to nuclear protein binding at a regulatory motif between nt-69 and -40.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Liou GI,Matragoon S,Overbeek PA,Fei Y

doi

10.1006/bbrc.1994.2406

subject

Has Abstract

pub_date

1994-09-30 00:00:00

pages

1875-81

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X84724065

journal_volume

203

pub_type

杂志文章

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