当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.

K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.

Abstract：

:A high incidence of oncogenic K-ras mutations is observed in lung adenocarcinoma of human cases and carcinogen-induced animal models. The process of oncogenic K-ras-mediated lung adenocarcinogenesis can be dissected into two parts: pre- and post-K-ras mutation. Adoption of transgenic lines containing a flox-K-rasG12V transgene eliminates the use of chemical carcinogens and enables us to study directly crucial events post-K-ras mutation without considering the cellular events involved with oncogenic K-ras mutation, e.g., distribution and metabolism of chemical carcinogens, DNA repair, and somatic recombination by host factors. We generated two mouse strains C57BL/6J-Ryr2(tm1Nobs) and A/J-Ryr2(tm1Nobs) in which K-rasG12V can be transcribed from the cytomegalovirus early enhancer/chicken beta actin promoter in virtually any tissue. Upon K-rasG12V induction in lung epithelial cells by an adenovirus expressing the Cre recombinase, the number of tumors in the C57BL/6J-Ryr2(tm1Nobs/+) mouse line was 12.5 times that in the A/J-Ryr2(tm1Nobs/+) mouse line. Quantitative trait locus (QTL) analysis revealed that new three modifier loci, D3Mit19, D3Mit45 and D11Mit20, were involved in the differential susceptibility between the two lines. In addition, we found that differential expression of the wild-type K-ras gene, which was genetically turn out to be anti-oncogenic activity on K-rasG12V, could not account for the different susceptibility in our two K-rasG12V-mediated lung tumor models. Thus, we provide a genetic system that enables us to explore new downstream modifiers post-K-ras mutation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Saito H,Suzuki N

doi

10.1016/j.bbrc.2014.09.052

subject

Has Abstract

pub_date

2014-10-03 00:00:00

pages

1067-70

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)01668-4

journal_volume

452

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • 1,2-Naphthoquinone disrupts the function of cAMP response element-binding protein through covalent modification.

    abstract：:1,2-Naphthoquinone (1,2-NQ) is an atmospheric contaminant with electrophilic properties that allow it to react readily with protein thiol groups such as those found on the cAMP response element-binding protein (CREB), a transcription factor with conserved cysteine residues that regulate DNA binding. In the present stu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.024

    authors： Endo A,Sumi D,Kumagai Y

    更新日期：2007-09-14 00:00:00

  • Intranuclear interactomic inhibition of FoxP3 suppresses functions of Treg cells.

    abstract：:Regulatory T cells (Treg cells) are crucial for the maintenance of immunological tolerance, and it has been reported that Treg cells are enriched within the tumor micro-environment for immune evasion due to their immunosuppressive functions. To inhibit Treg cells functions, FoxP3, a lineage-specific transcription fact...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.06.141

    authors： Park JH,Ko JS,Shin Y,Cho JY,Oh HA,Bothwell AL,Lee SK

    更新日期：2014-08-15 00:00:00

  • Separation of dolichol and dolichyl-P in microsomal and lysosomal compartments of hepatocytes.

    abstract：:The distribution, labeling and interrelationship of microsomal and lysosomal dolichol and dolichyl-P in rat liver was investigated. After membrane induction with phenobarbital, N-nitrosodiethylamine and diethylhexylphthalate, the amount of microsomal and lysosomal dolichols are modulated independently. Liposomal label...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(83)80022-9

    authors： Edlund C,Chojnacki T,Dallner G

    更新日期：1983-09-30 00:00:00

  • Bmcystatin, a cysteine proteinase inhibitor characterized from the tick Boophilus microplus.

    abstract：:The bovine tick Rhipicephalus (Boophilus) microplus is a blood-sucking animal, which is responsible for Babesia spp and Anaplasma marginale transmission for cattle. From a B. microplus fat body cDNA library, 465 selected clones were sequenced randomly and resulted in 60 Contigs. An open reading frame (ORF) contains 98...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.018

    authors： Lima CA,Sasaki SD,Tanaka AS

    更新日期：2006-08-18 00:00:00

  • Episodic positive selection during the evolution of naphthalene dioxygenase to nitroarene dioxygenase.

    abstract：:Using different maximum-likelihood models of adaptive evolution, signatures of natural selective pressure, operating across the naphthalene family of dioxygenases, were examined. A lineage- and branch-site specific combined analysis revealed that purifying selection pressure dominated the evolutionary history of the e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.029

    authors： Dutta A,Chakraborty J,Dutta TK

    更新日期：2013-10-11 00:00:00

  • Intracellular localization of SNAP-23 to endosomal compartments.

    abstract：:We have reexamined the intracellular localization of the ubiquitously expressed target membrane SNAP receptor (t-SNARE), SNAP-23. While SNAP-23 appears on the plasma membrane, in the cell types examined there is a significant pool associated with endosomal compartments. Immuno-staining and expression of green fluoresc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0173

    authors： Chen D,Whiteheart SW

    更新日期：1999-02-16 00:00:00

  • A bacteriophage transcription terminator permits the cloning of a mammalian expression vector carrying the human preprorenin gene in E. coli.

    abstract：:We constructed a plasmid-based expression vector carrying the murine metallothionein gene promoter, the human preprorenin gene, the Tn5 neomycin phosphotransferase II gene, and a complete bovine papilloma virus genome. We were unsuccessful in cloning the preprorenin gene in E. coli when it was inserted into a plasmid ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91395-7

    authors： Weighous TF,Tarpley WG

    更新日期：1987-03-13 00:00:00

  • Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells.

    abstract：:AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis and its activation during T cell receptor stimulation has recently been reported. In this study, we examined the role of AMPK in interleukin (IL)-2 production in T cells. Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.138

    authors： Jhun BS,Lee JY,Oh YT,Lee JH,Choe W,Baik HH,Kim SS,Yoon KS,Ha J,Kang I

    更新日期：2006-12-29 00:00:00

  • Temperature acclimation induces light meromyosin isoforms with different primary structures in carp fast skeletal muscle.

    abstract：:Carp acclimated to 10 degrees C gave 69k, 66k, and 62kDa light meromyosin (LMM) fragments in SDS-PAGE, while fish acclimated to 30 degrees C gave 74k, 69k, 66k, and 62kDa fragments. The microsequence analysis revealed that the 69k and 66kDa components from the 10 degrees C-acclimated carp contained an N-terminal amino...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1313

    authors： Watabe S,Imai J,Nakaya M,Hirayama Y,Okamoto Y,Masaki H,Uozumi T,Hirono I,Aoki T

    更新日期：1995-03-08 00:00:00

  • The C-C bond cleavage of a lignin model compound, 1,2-diarylpropane-1,3-diol, with a heme-enzyme model catalyst tetraphenylporphyrinatoiron(III)chloride in the presence of tert-butylhydroperoxide.

    abstract：:The catalytic C-C bond cleavage of a lignin model compound was investigated by use of tetraphenylporphyrinatoiron(III)chloride as a model for enzymic degradation of lignin. The C-C bond of the lignin model compound 1,2-bis(4-ethoxy-3-methoxyphenyl) propane-1,3-diol was oxidatively cleaved by catalysis of iron-porphyri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91226-9

    authors： Shimada M,Habe T,Umezawa T,Higuchi T,Okamoto T

    更新日期：1984-08-16 00:00:00

  • The role of EXT1 gene mutation and its high expression of calcitonin gene-related peptide in the development of multiple exostosis.

    abstract：OBJECTIVE:Screening and identifying the gene mutation of EXT1, EXT2 and EXT3 associated with multiple exostosis (ME) and the expression in tumor tissues. METHODS:Nine patients with multiple exostosis were collected and genomic DNA was extracted. Polymerase chain reaction (PCR) amplification and direct sequencing techn...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.09.115

    authors： Wu ZY,Wang Y,Wang JW,Chen YZ,Guo Y

    更新日期：2018-11-10 00:00:00

  • Establishment and characterization of transgenic mice expressing human platelet glycoprotein Ib alpha.

    abstract：:The platelet glycoprotein (GP) Ib/IX/V is a hetero-oligomeric receptor complex for von Willebrand factor (vWF) and mediates platelet adhesion and aggregation under high shear stress conditions. It is composed of alpha and beta chain of GP Ib, GP IX, AND and GP V. To establish transgenic mice carrying human GP Ib alpha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0420

    authors： Kitaguchi T,Murata M,Kuramochi T,Kobayashi K,Ito M,Ueyama Y,Nomura T,Hikichi K,Miyakawa Y,Handa M,Hiraoka Y,Aiso S,Ikeda Y

    更新日期：1996-03-18 00:00:00

  • p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival.

    abstract：:Vascular endothelial growth factor (VEGF) promotes vasculogenesis, arteriogenesis, and angiogenesis by stimulating proliferation, migration, and cell survival of endothelial cells. VEGF mediates its actions through activation of two receptor tyrosine kinases, VEGFR-1 and VEGFR-2. Serum starvation led to apoptosis of h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01064-7

    authors： Yilmaz A,Kliche S,Mayr-Beyrle U,Fellbrich G,Waltenberger J

    更新日期：2003-07-04 00:00:00

  • Differential sensitivity of Chironomus and human hemoglobin to gamma radiation.

    abstract：:Chironomus ramosus is known to tolerate high doses of gamma radiation exposure. Larvae of this insect possess more than 95% of hemoglobin (Hb) in its circulatory hemolymph. This is a comparative study to see effect of gamma radiation on Hb of Chironomus and humans, two evolutionarily diverse organisms one having extra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.05.129

    authors： Gaikwad PS,Panicker L,Mohole M,Sawant S,Mukhopadhyaya R,Nath BB

    更新日期：2016-08-05 00:00:00

  • Acyl-trafficking in membrane phospholipid fatty acid turnover: the transfer of fatty acid from the acyl-L-carnitine pool to membrane phospholipids in intact human erythrocytes.

    abstract：:In this work we have investigated the transfer of radioactive palmitic acid between membrane phospholipids and acyl-L-carnitines in intact human erythrocytes. During the incubation period of labeled erythrocyte in non-defatted bovine serum albumin, radioactivity in phosphatidylcholine and phosphatidylethanolamine incr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81500-1

    authors： Arduini A,Tyurin V,Tyuruna Y,Arrigoni-Martelli E,Molajoni F,Dottori S,Federici G

    更新日期：1992-08-31 00:00:00

  • Clock gene defect disrupts light-dependency of autonomic nerve activity.

    abstract：:The discovery of clock genes revealed the major molecular components responsible for circadian time-keeping in mammals, but the mechanism by which autonomic nervous system may control circadian rhythm and its relationship to metabolism is unclear. As the Cry1 and Cry2 genes are indispensable for molecular core oscilla...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.10.058

    authors： Ikeda H,Yong Q,Kurose T,Todo T,Mizunoya W,Fushiki T,Seino Y,Yamada Y

    更新日期：2007-12-21 00:00:00

  • Overexpression of UDP-glucose pyrophosphorylase gene could increase cellulose content in Jute (Corchorus capsularis L.).

    abstract：:In this study, the full-length cDNA of the UDP-glucose pyrophosphorylase gene was isolated from jute by homologous cloning (primers were designed according to the sequence of UGPase gene of other plants) and modified RACE techniques; the cloned gene was designated CcUGPase. Using bioinformatic analysis, the gene was i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.11.053

    authors： Zhang G,Qi J,Xu J,Niu X,Zhang Y,Tao A,Zhang L,Fang P,Lin L

    更新日期：2013-12-13 00:00:00

  • Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.

    abstract：:To identify novel psoriasis-associated genes, we focused on several ESTs (expressed sequence tags) whose expression was predominantly increased in the affected skin in patients with psoriasis vulgaris, as assessed by microarray assay. In this paper, a full-length cDNA corresponding to one of those ESTs (AI440266) was ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02344-6

    authors： Matsuzaka Y,Okamoto K,Tsuji H,Mabuchi T,Ozawa A,Tamiya G,Inoko H

    更新日期：2002-10-11 00:00:00

  • In vivo proteomic analysis of the intracellular bacterial pathogen, Francisella tularensis, isolated from mouse spleen.

    abstract：:Understanding the pathogenesis of infectious diseases requires comprehensive knowledge of the proteins expressed by the pathogen during in vivo growth in the host. Proteomics provides the tools for such analyses but the protocols required to purify sufficient quantities of the pathogen from the host organism are curre...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.05.070

    authors： Twine SM,Mykytczuk NC,Petit MD,Shen H,Sjöstedt A,Wayne Conlan J,Kelly JF

    更新日期：2006-07-14 00:00:00

  • Analysis of cag-8: a novel poly(Q)-encoding gene in the mouse brain.

    abstract：:We identified 13 transcript isoforms of a trinucleotide-repeat-containing gene, cag-8, that is expressed almost exclusively in the mouse brain. The polypeptide deduced from the cDNA consists of 137 AAs, of which 74 are glutamines. The 130-kb gene is composed of 16 exons, from which at least 13 isoforms with variable U...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.029

    authors： Ji JW,Yang HL,Kim SJ

    更新日期：2006-08-11 00:00:00

  • Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats.

    abstract：:Cell cultures of neonatal rat cerebral cortex in a serum-free medium were used to investigate a lack of neuronotrophic factors in Alzheimer's disease (AD) brain. A few neurons survived in the absence of brain extract. The addition of normal brain extract resulted in a 2.5-fold increase in neuronal survival. AD brain e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90765-6

    authors： Uchida Y,Ihara Y,Tomonaga M

    更新日期：1988-02-15 00:00:00

  • Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.

    abstract：:Type I diabetes is a complex disease in which multiple susceptibility loci have been implicated by whole genome scans. IDDM8, a susceptibility locus, is located on chromosome 6q27, however the specific susceptibility gene has yet to be identified. We have examined five potential candidate genes using 36 genetic marker...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.159

    authors： Owerbach D,Piña L,Gabbay KH

    更新日期：2004-10-22 00:00:00

  • Reversible methionine sulfoxidation of Mycobacterium tuberculosis small heat shock protein Hsp16.3 and its possible role in scavenging oxidants.

    abstract：:Mycobacterium tuberculosis (TB) small heat shock protein Hsp16.3 was found to be a major membrane protein that is most predominantly expressed under oxidative stress and is localized to the thickened cell envelope. Gene knock-out studies indicate that the Hsp16.3 protein is required for TB to grow in its host macropha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00685-5

    authors： Abulimiti A,Qiu X,Chen J,Liu Y,Chang Z

    更新日期：2003-05-23 00:00:00

  • The tetrapeptide Arg-Leu-Tyr-Glu inhibits VEGF-induced angiogenesis.

    abstract：:Kringle 5, derived from plasminogen, is highly capable of inhibiting angiogenesis. Here, we have designed and synthesized 10 tetrapeptides, based on the amino acid properties of the core tetrapeptide Lys-Leu-Tyr-Asp (KLYD) originating from anti-angiogenic kringle 5 of human plasminogen. Of these, Arg-Leu-Tyr-Glu (RLYE...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.05.073

    authors： Baek YY,Lee DK,So JH,Kim CH,Jeoung D,Lee H,Choe J,Won MH,Ha KS,Kwon YG,Kim YM

    更新日期：2015-08-07 00:00:00

  • Regulation by heme of the synthesis of cytochrome C oxidase subunits V and VII in yeast.

    abstract：:The effects of heme on the synthesis of subunits V and VII of cytochrome c oxidase were examined in the heme-deficient yeast mutant, GL1. In vitro translation and immunodetection with subunit-specific antisera indicated a 50% decrease in both proteins, with RNA obtained from hemeless cells. Unsupplemented, pulse-label...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91102-7

    authors： Gollub EG,Dayan J

    更新日期：1985-05-16 00:00:00

  • Hypoxia regulates the cAMP- and Ca2+/calmodulin signaling systems in PC12 cells.

    abstract：:Hypoxic/ischemic trauma is a primary factor in the pathology of various disease states. Yet, very little is known about the molecular mechanisms involved in cellular responses and adaptations to hypoxia. As a means of identifying intracellular signaling systems that are regulated in response to hypoxia, the effects of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7907

    authors： Beitner-Johnson D,Leibold J,Millhorn DE

    更新日期：1998-01-06 00:00:00

  • Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396.

    abstract：:The transcription of human nm23 genes (nm23-H1, nm23-H2) is involved in suppression of tumor metastasis or tumor progression. Therefore the characterization of transcriptional regulatory mechanisms for both nm23 genes is very important. In this study we have isolated and analyzed the 5'-flanking region of the human nm...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2550

    authors： Seifert M,Seib T,Engel M,Dooley S,Welter C

    更新日期：1995-10-24 00:00:00

  • Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells.

    abstract：:We examined the effects of troglitazone on expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Troglitazone dose-dependently increased expression of E-cadherin and claudin 4 mRNA and protein in PK-1 cells. Snail, Slug and ZEB1, mRNAs were not changed by troglitazone, indicating that these three tr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.01.134

    authors： Kumei S,Motomura W,Yoshizaki T,Takakusaki K,Okumura T

    更新日期：2009-03-13 00:00:00

  • Purification of normal cellular prion protein from human platelets and the formation of a high molecular weight prion protein complex following platelet activation.

    abstract：:A method for the extraction and purification of PrP(C), in its native monomeric form, from outdated human platelet concentrates is described. Both calcium ionophore platelet activation and lysis in Triton X-100 were evaluated as methods for the extraction of soluble platelet PrP(C) in its monomeric form. Following pla...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.045

    authors： Jones M,Head MW,Connolly JG,Farquhar CF,Hornsey VS,Pepper DS,MacGregor IR

    更新日期：2005-09-16 00:00:00

  • A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase.

    abstract：:O2-dependent reactions of the ferric and ferrous forms of alpha-hydroxyheme complexed with water-soluble rat heme oxygenase-1 were examined by rapid-scan stopped-flow measurements. Ferric alpha-hydroxyheme reacted with O2 to form ferric verdoheme with an O2-dependent rate constant of 4x10(5) M(-1) s(-1) at pH 7.4 and ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.176

    authors： Sakamoto H,Takahashi K,Higashimoto Y,Harada S,Palmer G,Noguchi M

    更新日期：2005-12-09 00:00:00