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Inhibition of the catalytic subunit of ram sperm adenylate cyclase by adenosine.

Abstract：

:Adenosine inhibits ram sperm adenylate cyclase activity which is membrane-bound and comprises only the catalytic subunit. The inhibition parameters of adenylate cyclase by adenosine were not modified when the enzyme was purified 3 to 5,000 fold. Optimal inhibition by adenosine was found to require a high concentration of manganese, and exhibited a noncompetitive pattern up to a concentration of 1 mM adenosine. Adenosine was the most potent inhibitor among various analogs tested with the following rank order of potencies: adenosine greater than 2'O-methyladenosine greater than 2'deoxyadenosine much greater than 2 chloroadenosine. Studies with agonists and antagonists of the "R"-type adenosine receptor led us to conclude that adenosine inhibits ram sperm adenylate cyclase via a "P"-site carried by the catalytic subunit itself.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Henry D,Ferino F,Tomova S,Ferry N,Stengel D,Hanoune J

doi

10.1016/0006-291x(86)90320-7

subject

Has Abstract

pub_date

1986-06-30 00:00:00

pages

970-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)90320-7

journal_volume

137

pub_type

杂志文章

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