A mammalian peptidoglycan recognition protein with N-acetylmuramoyl-L-alanine amidase activity.

abstract：:Myocardial ischemia/reperfusion (I/R) still have high morbidity and mortality worldwide. Platelet activating factor (PAF) is a potent phospholipid regulator of inflammation. PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear membranes of various cell types. The study is aimed to explore i...

journal_title：Biochemical and biophysical research communications

authors： Wang EW,Han YY,Jia XS

更新日期：2018-01-22 00:00:00

abstract：:A mass screening program for congenital hypothyroidism has markedly improved prognosis of children with congenital hypothyroidism and also revealed several cases with unknown pathogenesis. We here report two independent Japanese multigeneration families with multinodular goiter (MNG) with euthyroidism and with high TS...

journal_title：Biochemical and biophysical research communications

authors： Takahashi T,Nozaki J,Komatsu M,Wada Y,Utsunomiya M,Inoue K,Takada G,Koizumi A

更新日期：2001-06-15 00:00:00

abstract：:Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation ...

journal_title：Biochemical and biophysical research communications

authors： Ni B,Farrar JS,Chen S,Lownik JC,Celi FS

更新日期：2018-07-02 00:00:00

abstract：:Adrenomedullin (ADM) is a vasodilator peptide, first isolated from human pheochromocytoma. To explore the pathophysiological role of ADM in ischemic conditions, we investigated the effects of hypoxia on ADM production and ADM mRNA expression in a cultured human colorectal carcinoma cell line, DLD-1. Northern blot anal...

journal_title：Biochemical and biophysical research communications

authors： Nakayama M,Takahashi K,Murakami O,Shirato K,Shibahara S

更新日期：1998-02-13 00:00:00

abstract：:Comparative fluorimetric, flow cytofluorimetric and fluorescence ratiometric determinations of intracellular K+ concentrations in murine haemopoietic cells (FDCP-Mix clone A4) cultured in the presence and absence of the specific growth factor Interleukin-3 were carried out with the fluorescent potassium-binding benzof...

journal_title：Biochemical and biophysical research communications

authors： Laskay G,Várhelyi T,Dale RE,Dexter TM

更新日期：1995-09-14 00:00:00

abstract：:The suppressor of cytokine signalling 1 protein (SOCS-1) belongs to a novel family of cytokine inducible factors which function as inhibitors of the JAK/STAT pathway. While SOCS-1 previously has been described as a single-exon gene, here we present evidence for an additional 5' exon, separated by a 509 bp intron from ...

journal_title：Biochemical and biophysical research communications

authors： Schlüter G,Boinska D,Nieman-Seyde SC

更新日期：2000-02-16 00:00:00

abstract：:Receptor activator of nuclear factor kappa B (RANK) is a tumor necrosis factor receptor (TNFR) family protein that plays an important role in the regulation of bone and immune systems. Cellular responses to RANK ligand (RANKL) and the signal transduction pathways of RANK have been well characterized in osteoclasts and...

journal_title：Biochemical and biophysical research communications

authors： Lee ZH,Kim HH

更新日期：2003-05-30 00:00:00

abstract：:The role of hepatic nuclear factor 1α (HNF-1α) and its response element in the expression of glutathione S-transferase A1 (GSTA1) was investigated in hepatocytes cells injury induced by acetaminophen (APAP). Treatment of hepatocytes with C2-ceramide exacerbated cells injury with GSTA1 mRNA level reducing. Contrastingl...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Hao B,Muhammad I,Zhang Y,Yang Y,Shi C,Chang Y,Li R,Li C,Liu F

更新日期：2019-08-13 00:00:00

abstract：:Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and diseas...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Iwai A,Nakayama Y,Morimoto J,Takada A,Maruyama M,Kida H,Uede T,Miyazaki T

更新日期：2012-01-06 00:00:00

abstract：:In the brain angiotensin converting enzyme is highly localized to a striatonigral pathway, which contains no endogenous angiotensin. Substance P, also localized to a striatonigral pathway, is degraded by ACE via two different pathways. The lung and striatal isozymes of angiotensin converting enzyme exhibit differentia...

journal_title：Biochemical and biophysical research communications

authors： Thiele EA,Strittmatter SM,Snyder SH

更新日期：1985-04-16 00:00:00

abstract：:Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrulline residues Ca(2+)-dependently. PAD V was recently found in granulocyte-differentiated HL-60 cells. To find a target of PAD V, we incubated HL-60 granulocytes with the calcium ionophore A23187 and studied deiminated proteins by immun...

journal_title：Biochemical and biophysical research communications

authors： Hagiwara T,Nakashima K,Hirano H,Senshu T,Yamada M

更新日期：2002-01-25 00:00:00

abstract：:Transthyretin (TTR) is a human disease-associated amyloidogenic protein that has been implicated in senile systemic amyloidosis (SSA) and familial amyloidotic polyneuropathy (FAP). FAP typically results in severe and early-onset disease, and the only therapy established so far is liver transplantation; thus, developin...

journal_title：Biochemical and biophysical research communications

authors： Lee KW,Lee DH,Son H,Kim YS,Park JY,Roh GS,Kim HJ,Kang SS,Cho GJ,Choi WS

更新日期：2009-10-16 00:00:00

abstract：:A major component of amyloid deposits found in Alzheimer disease and Down syndrome is the beta/A4 peptide, which is derived from the Alzheimer amyloid protein precursor (APP). Recent evidence indicates that increases in APP expression and/or beta/A4 peptide accumulation may underlie the amyloidosis characteristic of t...

journal_title：Biochemical and biophysical research communications

authors： Buxbaum JD,Christensen JL,Ruefli AA,Greengard P,Loring JF

更新日期：1993-12-15 00:00:00

abstract：:A method is described for quantitation of charged detergents using their hemolytic property in an electrophoresis assay in agarose gels containing red blood cells. After electrophoresis the zone of hemolysis is directly proportional to the concentration of detergent in the sample. Using this technique we have determin...

journal_title：Biochemical and biophysical research communications

authors： Sundquist B,Dalsgaard K,Morein B

更新日期：1983-07-29 00:00:00

abstract：:The aminoglycoside antibiotic (AGA) neomycin is a known agonist of the extracellular calcium-sensing receptor (CaR). To test whether other AGA drugs stimulate the CaR, we studied the relative effects of four AGAs on intracellular Ca(2+) concentration ([Ca(2+)](i)) using CaR-transfected human embryonic kidney (HEK)-293...

journal_title：Biochemical and biophysical research communications

authors： McLarnon S,Holden D,Ward D,Jones M,Elliott A,Riccardi D

更新日期：2002-09-13 00:00:00

abstract：:The amino acid sequence of the polyclonal antibodies we developed against the carboxyl terminus of the dystrophin-related protein, the putative gene product of B3 cDNA, had no homologous sequence to the dystrophin molecule except for two amino acids located at its ends for immunization. By immunohistochemical examinat...

journal_title：Biochemical and biophysical research communications

authors： Takemitsu M,Ishiura S,Koga R,Kamakura K,Arahata K,Nonaka I,Sugita H

更新日期：1991-11-14 00:00:00

abstract：:To identify novel psoriasis-associated genes, we focused on several ESTs (expressed sequence tags) whose expression was predominantly increased in the affected skin in patients with psoriasis vulgaris, as assessed by microarray assay. In this paper, a full-length cDNA corresponding to one of those ESTs (AI440266) was ...

journal_title：Biochemical and biophysical research communications

authors： Matsuzaka Y,Okamoto K,Tsuji H,Mabuchi T,Ozawa A,Tamiya G,Inoko H

更新日期：2002-10-11 00:00:00

abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

journal_title：Biochemical and biophysical research communications

authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

更新日期：1989-01-16 00:00:00

abstract：:Atriopeptin (AP) is synthesized and stored in the mammalian atria as a 126 amino acid prohormone (AP126). Upon secretion, the prohormone undergoes site specific proteolysis within the atria to yield the carboxyl terminal 28 amino acid hormone (AP28). The atrial cell responsible for AP126 bioactivation has not yet been...

journal_title：Biochemical and biophysical research communications

authors： Greenwald JE,Needleman P,Siegel N,Tetens E,Biel B,Ritter D

更新日期：1992-10-30 00:00:00

abstract：:Cox-2 plays an important role in colon carcinogenesis and inflammation. Studying the HT-29 colon cancer cell line as a model, we found that Cox-2 expression and activity is increased approximately 25-fold by TNF-alpha. As previously reported for other Cox-2 inducers, this activation appears to result from a p38-mediat...

journal_title：Biochemical and biophysical research communications

authors： Tong X,Yin L,Giardina C

更新日期：2004-04-30 00:00:00

abstract：:The α2-adrenoceptor inducer dexmedetomidine protects against acute lung injury (ALI), but the mechanism of this effect is largely unknown. The present study investigated the effect of dexmedetomidine on apoptosis induced by lipopolysaccharide (LPS) and the relationship between this effect and gap junction intercellula...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Tan X,Xue L

更新日期：2018-01-01 00:00:00

abstract：:Ischemic stroke is a major cause of death and disability worldwide. Hyperneuroinflammation significantly contributes to ischemic stroke. Bromodomain-containing protein 4 (BRD4) is a member of the Bromo and Extra-Terminal (BET) family, and promotes inflammatory response in various types of tissue and cells. Thereby, we...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Gu Y,Liu J

更新日期：2019-11-12 00:00:00

abstract：:Alpha-synuclein is a major component of several pathological lesions diagnostic of specific neurodegenerative disease such as Parkinson's disease. This study focuses on the non-amyloid beta component of Alzheimer's disease amyloid, a key region for the aggregation and fibril formation of alpha-synuclein. Several mutat...

journal_title：Biochemical and biophysical research communications

authors： Sode K,Usuzaka E,Kobayashi N,Ochiai S

更新日期：2005-09-23 00:00:00

abstract：:Cytochrome c3 (Mr 26,000) has been characterized in Desulfovibrio vulgaris (Hildenborough) and its properties compared with polyhemic cytochromes c isolated from the same organism and from D. desulfuricans (Norway). It can be described as an octaheme cytochrome c3 constituted of two identical subunits. Absorption spec...

journal_title：Biochemical and biophysical research communications

authors： Loutfi M,Guerlesquin F,Bianco P,Haladjian J,Bruschi M

更新日期：1989-03-15 00:00:00

abstract：:To establish a simple system for purification of recombinant infectious hepatitis C virus (HCV) particles, we designed a chimeric J6/JFH-1 virus with a FLAG (FL)-epitope-tagged sequence at the N-terminal region of the E2 hypervariable region-1 (HVR1) gene (J6/JFH-1/1FL). We found that introduction of an adaptive mutat...

journal_title：Biochemical and biophysical research communications

authors： Takahashi H,Akazawa D,Kato T,Date T,Shirakura M,Nakamura N,Mochizuki H,Tanaka-Kaneko K,Sata T,Tanaka Y,Mizokami M,Suzuki T,Wakita T

更新日期：2010-05-14 00:00:00

abstract：:A combination of the RT-PCR method and subsequent screening of the cDNA library of mouse skeletal muscle with the cDNA isolated by RT-PCR used as a probe led to isolation of cDNAs encoding a polypeptide (mSim) with bHLH and PAS domains which show high similarity to the corresponding regions of Drosophila Sim, a master...

journal_title：Biochemical and biophysical research communications

authors： Ema M,Suzuki M,Morita M,Hirose K,Sogawa K,Matsuda Y,Gotoh O,Saijoh Y,Fujii H,Hamada H,Fujii-Kuriyama Y

更新日期：1996-01-17 00:00:00

abstract：:IGF-I, when added to TSH-primed FRTL-5 cells, induces a long lasting Ca2+ influx and then DNA synthesis. Ca2+ channel agonist, BAYK 8644, is capable to mimic these effects on cell proliferation. We studied the effect of genistein, a specific tyrosine kinase inhibitor, on BAY K8644- or IGF-I- induced cell cycle progres...

journal_title：Biochemical and biophysical research communications

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1993-02-15 00:00:00

abstract：:The majority of studies on possible roles for collagen hydrolysates in human health have focused on their effects on bone and skin. Hydroxyprolyl-glycine (Hyp-Gly) was recently identified as a novel collagen hydrolysate-derived dipeptide in human blood. However, any possible health benefits of Hyp-Gly remain unclear. ...

journal_title：Biochemical and biophysical research communications

authors： Kitakaze T,Sakamoto T,Kitano T,Inoue N,Sugihara F,Harada N,Yamaji R

更新日期：2016-09-23 00:00:00

abstract：:The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in obese, diabetic ob/ob mice and in lean, non-diabetic littermates using the selective inhibitor, milrinone. Oral administration of milrinone increased plasma insu...

journal_title：Biochemical and biophysical research communications

authors： Parker JC,VanVolkenburg MA,Nardone NA,Hargrove DM,Andrews KM

更新日期：1997-07-30 00:00:00

abstract：:Various methods have been used to evaluate anti-fibrotic activity of drugs. However, most of them are complicated, labor-intensive and lack of efficiency. This study was intended to develop a rapid method for anti-fibrotic drugs screening based on biophysical properties. A549 cells in vitro were stimulated with transf...

journal_title：Biochemical and biophysical research communications

authors： Liu M,Zheng M,Xu H,Liu L,Li Y,Xiao W,Li J,Ma E

更新日期：2015-12-04 00:00:00