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Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells.

Abstract：

:Adrenomedullin (ADM) is a vasodilator peptide, first isolated from human pheochromocytoma. To explore the pathophysiological role of ADM in ischemic conditions, we investigated the effects of hypoxia on ADM production and ADM mRNA expression in a cultured human colorectal carcinoma cell line, DLD-1. Northern blot analysis and radioimmunoassay showed that hypoxia stimulated the accumulation of ADM mRNA in the DLD-1 cells and immunoreactive ADM (ir-ADM) in the cultured media. Exposure to hypoxia for 12 hours increased ADM mRNA levels about 6-fold and ir-ADM levels about 4-fold. Moreover, treatment of DLD-1 cells with cobalt chloride, which mimics hypoxic states, significantly increased ADM mRNA levels about 18-fold and ir-ADM levels about 4-fold. These results suggest that ADM plays an important role in the pathophysiology of ischemic states.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nakayama M,Takahashi K,Murakami O,Shirato K,Shibahara S

doi

10.1006/bbrc.1998.8131

subject

Has Abstract

pub_date

1998-02-13 00:00:00

pages

514-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98131-1

journal_volume

243

pub_type

杂志文章

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