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Role of p120-catenin in the morphological changes of endothelial cells exposed to fluid shear stress.

Abstract：

:p120-Catenin is known to play important roles in cell-cell adhesion stability by binding to cadherin and morphological changes of cells by regulating small RhoGTPase activities. Although the expression and binding states of p120-catenin are thought to dynamically change due to morphological adaptation of endothelial cells (ECs) to fluid shear stress, these dynamics remain to be explored. In the present study, we examined the time course of changes in p120-catenin expression and its binding to vascular endothelial (VE)-cadherin in ECs exposed to shear stress. Human umbilical vein ECs began to change their morphologies at 3-6h, and became elongated and oriented to the direction of flow at 24h after exposure to a shear stress of 1.5Pa. Binding and co-localization of p120-catenin with VE-cadherin at the foci of cell-cell adhesions were retained in ECs during exposure to shear stress, indicating that VE-cadherin was stabilized in the plasma membrane. In contrast, cytoplasmic p120-catenin that was dissociated from VE-cadherin was transiently increased at 3-6h after the flow onset. These results suggest that the transient increase of cytoplasmic p120-catenin may stimulate RhoGTPase activities and act as a switch for the morphological changes in ECs in response to shear stress.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sakamoto N,Segawa K,Kanzaki M,Ohashi T,Sato M

doi

10.1016/j.bbrc.2010.06.092

subject

Has Abstract

pub_date

2010-07-30 00:00:00

pages

426-32

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)01232-5

journal_volume

398

pub_type

杂志文章

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