Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma.


:Resolvin E1 (RvE1; 5S, 12R, 18R-trihydroxyeicosapentaenoic acid) is an anti-inflammatory lipid mediator derived from the omega-3 fatty acid eicosapentaenoic acid (EPA). It has been recently shown that RvE1 is involved in the resolution of inflammation. However, it is not known whether RvE1 is involved in the resolution of asthmatic inflammation. To investigate the anti-inflammatory effect of RvE1 in asthma, a murine model of asthma was studied. After RvE1 was administered to mice intraperitoneally, there were decreases in: airway eosinophil and lymphocyte recruitment, specific Th2 cytokine, IL-13, ovalbumin-specific IgE, and airway hyperresponsiveness (AHR) to inhaled methacholine. Moreover, RvE1-treated mice had significantly lower mucus scores compared to vehicle-treated mice based on the number of goblet cells stained with periodic acid-schiff (PAS). These findings provide evidence that RvE1 is a pivotal counterregulatory signal in allergic inflammation and offer novel multi-pronged therapeutic approaches for human asthma.


Aoki H,Hisada T,Ishizuka T,Utsugi M,Kawata T,Shimizu Y,Okajima F,Dobashi K,Mori M




Has Abstract


2008-03-07 00:00:00














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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lin N,Liu S,Li N,Wu P,An H,Yu Y,Wan T,Cao X

    更新日期:2004-08-20 00:00:00

  • Overstretching partially alkyne functionalized dsDNA using near infrared optical tweezers.

    abstract::The force-extension behaviour of synthesized double-stranded DNAs (dsDNAs) designed to have 2.1% or 6.6% of the thymine bases alkyne functionalized was studied using near infrared (NIR) optical tweezers. Measurements were carried out on substrates with and without flurophores covalently attached to the alkyne moiety o...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Raudsepp A,Kent LM,Hall SB,Williams MAK

    更新日期:2018-02-12 00:00:00

  • Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins.

    abstract::The binding of four potent antimitotic agents, rhizoxin (RZX), phomopsin A (PMS-A), ansamitocin P-3 (ASMP-3), and vinblastine (VLB), to tubulins from RZX-sensitive and -resistant strains of Aspergillus nidulans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae was investigated. Mycelial extracts to which RZX co...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Li Y,Kobayashi H,Hashimoto Y,Iwasaki S

    更新日期:1992-09-16 00:00:00

  • Transplantation of dermal fibroblasts expressing MyoD1 in mouse muscles.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Huard C,Moisset PA,Dicaire A,Merly F,Tardif F,Asselin I,Tremblay JP

    更新日期:1998-07-30 00:00:00

  • Stimulus-induced phosphorylation of PKC theta at the C-terminal hydrophobic-motif in human T lymphocytes.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Freeley M,Volkov Y,Kelleher D,Long A

    更新日期:2005-08-26 00:00:00

  • Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Shichiri H,Yamamoto K,Tokura M,Ishida T,Uda A,Bito T,Nishigori C,Nakagawa T,Hirano T,Yano I,Hirai M

    更新日期:2017-04-01 00:00:00

  • Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yao I,Ohtsuka T,Kawabe H,Matsuura Y,Takai Y,Hata Y

    更新日期:2000-04-13 00:00:00

  • Stimulation of calcium entry is prerequisite for DNA synthesis induced by platelet-derived growth factor in vascular smooth muscle cells.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mogami H,Kojima I

    更新日期:1993-10-29 00:00:00

  • Functional studies of human GLUT5: effect of pH on substrate selection and an analysis of substrate interactions.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kane S,Seatter MJ,Gould GW

    更新日期:1997-09-18 00:00:00

  • Effect of STI-571 (imatinib mesylate) in combination with retinoic acid and gamma-irradiation on viability of neuroblastoma cells.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rössler J,Zambrzycka I,Lagodny J,Kontny U,Niemeyer CM

    更新日期:2006-04-21 00:00:00

  • A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hirota Y,Kuronita T,Fujita H,Tanaka Y

    更新日期:2007-12-07 00:00:00

  • DMLR: A toolkit for investigation of deoxyribozyme-mediated ligation based on real time PCR.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Dehghanian F,Najafi ZB,Hojati Z,Javadi-Zarnaghi F

    更新日期:2020-04-02 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kawasaki M,Makino S,Matsuzawa H,Satow Y,Ohya Y,Anraku Y

    更新日期:1996-05-24 00:00:00

  • Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ikedo T,Minami M,Kataoka H,Hayashi K,Nagata M,Fujikawa R,Yamazaki F,Setou M,Yokode M,Miyamoto S

    更新日期:2018-01-01 00:00:00

  • Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ransjö M,Sahli J,Lie A

    更新日期:2003-04-18 00:00:00

  • Glutathione S-transferase isozymes of mouse intestine: differential induction by 2(3)-tert-butyl-4-hydroxyanisole.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Parchment RE,Benson AM

    更新日期:1984-03-30 00:00:00

  • Purification and identification of endogenous anti-opioid substances from bovine brain.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kaneko S,Tamura S,Takagi H

    更新日期:1985-01-16 00:00:00

  • A possible role of protein kinase C in signal-induced lysosomal enzyme release.

    abstract::In platelets, activation of protein kinase C and mobilization of Ca2+ were selectively induced by the addition of 1-oleoyl-2-acetyl-glycerol and a low concentration of A23187, respectively (Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 6701-6704). Using...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    更新日期:1983-10-31 00:00:00

  • Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2).

    abstract::We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kin...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ababneh M,Götz C,Montenarh M

    更新日期:2001-05-04 00:00:00

  • SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Shou J,Cao J,Zhang S,Sun R,Zhao M,Chen K,Su SB,Yang J,Yang T

    更新日期:2018-09-05 00:00:00

  • Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yumoto F,Lu QW,Morimoto S,Tanaka H,Kono N,Nagata K,Ojima T,Takahashi-Yanaga F,Miwa Y,Sasaguri T,Nishita K,Tanokura M,Ohtsuki I

    更新日期:2005-12-23 00:00:00

  • Intensified autophagy compromises the efficacy of radiotherapy against prostate cancer.

    abstract:INTRODUCTION:Radiotherapy is an equivalent alternative or complement to radical prostatectomy, with high therapeutic efficacy. High risk patients, however, experience high relapse rates, so that research on radio-sensitization is the most evident route to improve curability of this common disease. MATERIALS AND METHOD...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Koukourakis MI,Kalamida D,Mitrakas A,Pouliliou S,Kalamida S,Sivridis E,Giatromanolaki A

    更新日期:2015-05-29 00:00:00

  • Interaction of myosin subfragment-1 with F- and G-actin in equilibrium.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Carlier MF,Didry D

    更新日期:1992-03-31 00:00:00

  • Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway.

    abstract::Alzheimer's disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Although cytotoxicity of amyloid β peptides has been intensively studied within pathophysiology of AD, the physiological function of amyloid precursor protein (APP) still remains unclarified. We have shown previously tha...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kwak YD,Hendrix BJ,Sugaya K

    更新日期:2014-05-09 00:00:00

  • Purification of the mitochondrial citrate transporter in yeast.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Persson LO,Srere PA

    更新日期:1992-02-28 00:00:00

  • Biochemical evidence for the long-tail form (A beta 1-42/43) of amyloid beta protein as a seed molecule in cerebral deposits of Alzheimer's disease.

    abstract::We measured the amounts of total A beta, A beta 1-40 and A beta 1-42/43 in brain tissues using a newly developed ELISA assay and found that the amounts of insoluble A beta 1-42/43 and insoluble A beta 1-40 were linearly related to the amount of A beta deposits or total insoluble A beta at their lower and higher concen...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tamaoka A,Kondo T,Odaka A,Sahara N,Sawamura N,Ozawa K,Suzuki N,Shoji S,Mori H

    更新日期:1994-11-30 00:00:00

  • Acetyl-CoA carboxylase is essential for nutrient-induced insulin secretion.

    abstract::In pancreatic beta-cells, stimulation of insulin secretion by glucose and other nutrients requires metabolism of these nutrients to acetyl-CoA. Circumstantial evidence suggests that the conversion of acetyl-CoA to malonyl-CoA, which is a powerful inhibitor for carnitine palmitoyltransferase 1 and fatty acid oxidation,...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhang S,Kim KH

    更新日期:1996-12-24 00:00:00

  • Ca(2+)-channels and adrenoceptors in diabetic skeletal muscle.

    abstract::The status of Ca(2+)-channels and adrenoceptors in the hind leg skeletal muscle was examined in rats 8 weeks after inducing diabetes by an intravenous injection of streptozotocin (65 mg/kg). Scatchard plot analysis of the data on specific binding of 3H-nitrendipine with crude membranes from diabetic muscle revealed an...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lee SL,Dhalla NS

    更新日期:1992-04-15 00:00:00

  • Alpha 2-antiplasmin's carboxy-terminal lysine residue is a major site of interaction with plasmin.

    abstract::alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly complexes covalently with the enzyme's active site. Here, we show that the C-terminal lysine residue of AP has a key role in binding of the inhibitor to plasmin. A syn...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hortin GL,Gibson BL,Fok KF

    更新日期:1988-09-15 00:00:00

  • The ras-binding domain of ral GDS-like protein-2 as a ras inhibitor in smooth muscle cells.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fischer TH,Brittain J,Trabalzini L,Banes AJ,White GC,Smith CJ,Nichols TC

    更新日期:2003-06-13 00:00:00