当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Isoform-specific proteasomal degradation of Rbfox3 during chicken embryonic development.

Isoform-specific proteasomal degradation of Rbfox3 during chicken embryonic development.

Abstract：

:Rbfox3, a neuron-specific RNA-binding protein, plays an important role in neuronal differentiation during development. An isoform Rbfox3-d31, which excludes the 93-nucleotide cassette exon within the RNA recognition motif of chicken Rbfox3, has been previously identified. However, the cellular functions of Rbfox3-d31 remain largely unknown. Here we find that Rbfox3-d31 mRNA is highly expressed during the early developmental stages of the chicken embryo, while Rbfox3-d31 protein is barely detected during the same stage due to its rapid degradation mediated by the ubiquitin-proteasome pathway. Importantly, this degradation is specific to the Rbfox3-d31 isoform and it does not occur with full-length Rbfox3. Furthermore, suppression of Rbfox3-d31 protein degradation with the proteasome inhibitor MG132 attenuates the splicing activity of another Rbfox family member Rbfox2 by altering the subcellular localization of Rbfox2. These results suggest that Rbfox3-d31 functions as a repressor for the splicing activity of the Rbfox family and its protein level is regulated in an isoform-specific manner in vivo.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kim KK,Adelstein RS,Kawamoto S

doi

10.1016/j.bbrc.2014.07.057

subject

Has Abstract

pub_date

2014-08-08 00:00:00

pages

1662-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)01285-6

journal_volume

450

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Protein kinase C inhibits autophagy and phosphorylates LC3.

    abstract：:During autophagy, the microtubule-associated protein light chain 3 (LC3), a specific autophagic marker in mammalian cells, is processed from the cytosolic form (LC3-I) to the membrane-bound form (LC3-II). In HEK293 cells stably expressing FLAG-tagged LC3, activation of protein kinase C inhibited the autophagic process...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.04.030

    authors： Jiang H,Cheng D,Liu W,Peng J,Feng J

    更新日期：2010-05-14 00:00:00

  • Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9.

    abstract：:We have classified microvesicles into two subtypes: larger MVs released upon stimulation of prostate cancer cells, sMVs, and smaller cMVs, released constitutively. cMVs are released as part of cell metabolism and sMVs, released at 10-fold higher levels, produced upon activation, including sublytic C5b-9. From electron...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.03.074

    authors： Stratton D,Moore C,Antwi-Baffour S,Lange S,Inal J

    更新日期：2015-05-08 00:00:00

  • An epitope on the stem region of hemagglutinin of H1N1 influenza A virus recognized by neutralizing monoclonal antibody.

    abstract：:Influenza A viruses are a major threat to human health and inflict a significant public health challenge worldwide. Hemagglutinin (HA) is the main contributor to the infectivity of the virus and is a potential target for the development of antiviral therapeutic agents. The stem region of HA, which has been shown to be...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.08.055

    authors： Yan L,Wang H,Sun L,Liu Y,Sun J,Zhao X,Li Y,Xie X,Hu J

    更新日期：2019-10-15 00:00:00

  • A new function of Ito cells in liver morphogenesis: evidence using a novel morphogenic protein, epimorphin, in vitro.

    abstract：:A novel mesenchymal protein, epimorphin, has been reported to play a key role in morphogenesis of fetal organs. The morphological and functional features of epimorphin in adult liver were entirely unknown. This study was performed to determine the distribution and function of this protein in the adult mouse liver. Epi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1146

    authors： Hirose M,Watanabe S,Oide H,Kitamura T,Miyazaki A,Sato N

    更新日期：1996-08-05 00:00:00

  • Interaction of estrogen receptor complexes with the promoter region of genes that are negatively regulated by estrogens: the alpha 2u-globulins.

    abstract：:Since estrogens strongly suppress the expression of alpha 2u-globulin genes in the rat liver, we studied the binding of estrogen-receptor complexes to fragments derived from alpha 2u-globulin gene RAO 01 using a DNA-cellulose competition assay. Rat uterus cytosol labelled with [3H]estradiol was used as a source of the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80127-5

    authors： Van Dijck P,Verhoeven G

    更新日期：1992-01-15 00:00:00

  • The interaction between the pleckstrin homology domain of ceramide kinase and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels.

    abstract：:Ceramide kinase (CERK) converts ceramide to ceramide-1-phosphate (C1P), which has recently emerged as a new bioactive molecule capable of regulating diverse cellular functions. The N-terminus of the CERK protein encompasses a sequence motif known as a pleckstrin homology (PH) domain. Although the PH domain was previou...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.01.170

    authors： Kim TJ,Mitsutake S,Igarashi Y

    更新日期：2006-04-07 00:00:00

  • Chinchilla "big" and "little" gastrins.

    abstract：:Gastrin heptadecapeptides (gastrins I and II which differ in the presence of sulfate on the tyrosine of the latter) have been purified and sequenced from several mammalian species including pig, dog, cat, sheep, cow, human and rat. A 34 amino acid precursor ("big" gastrin), generally accounting for only 5% of total ga...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90621-8

    authors： Shinomura Y,Eng J,Yalow RS

    更新日期：1987-02-27 00:00:00

  • The distribution and intracellular translocation of aflatoxin B1 in isolated hepatocytes.

    abstract：:The distribution and intracellular translocation of AFB1 in various subcellular fractions was investigated in isolated hepatocytes by pulse-chase experiments. After labeling the hepatocytes with [3H]-AFB1 (14.5 nM) for 15 min, the highest concentration of [3H]-AFB1 was found in the cytosolic fraction where 66% was bou...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90430-3

    authors： Ch'ih JJ,Devlin TM

    更新日期：1984-07-18 00:00:00

  • A novel microgravimetric DNA sensor with high sensitivity.

    abstract：:A novel method using an amplifier with a cantilever and gold nanoparticles successfully to extend the length of the target for the specific and high sensitive detection of DNA was reported. When the size of gold nanoparticle is 50 nm, a sensitivity of 10(-15)M for the single base mutation detection has been achieved. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00531-x

    authors： Liu T,Tang J,Han M,Jiang L

    更新日期：2003-04-25 00:00:00

  • Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population.

    abstract：:Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and diseas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.100

    authors： Sato K,Iwai A,Nakayama Y,Morimoto J,Takada A,Maruyama M,Kida H,Uede T,Miyazaki T

    更新日期：2012-01-06 00:00:00

  • Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus.

    abstract：:Flavivirus non-structural protein 4A (NS4A) induces membrane rearrangements to form viral replication complex and functions as interferon antagonist. However, other non-structural roles of NS4A protein in relation to virus life-cycle are poorly defined. This study elucidated if dengue virus (DENV) NS4A protein interac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.05.036

    authors： Jiang L,Yao H,Duan X,Lu X,Liu Y

    更新日期：2009-07-24 00:00:00

  • Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice.

    abstract：:Activation of the classical IκB kinases (IKKα and IKKβ) was previously shown to contribute to obesity-induced inflammation and insulin resistance. Using knockout mice, we investigated whether the related isoform IKKε plays a similar metabolic role. IKKε(-/-) mice had reduced body weight, leptin levels, as well as high...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.02.137

    authors： Scheja L,Heese B,Seedorf K

    更新日期：2011-04-08 00:00:00

  • 2-((2-Pyridylmethyl)sulfinyl)benzimidazoles: acid sensitive suicide inhibitors of the proton transport system in the parietal cell.

    abstract：:2-((2-Pyridylmethyl)sulfinyl)benzimidazoles, selective inhibitors of the H+/K+-ATPase in the parietal cells of the stomach, have been investigated concerning their chemical behaviour in acidic medium. Protonation of the sulfoxide and subsequent elimination of water forms a sulfenium ion or a chemical equivalent thereo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91703-6

    authors： Rackur G,Bickel M,Fehlhaber HW,Herling A,Hitzel V,Lang HJ,Rösner M,Weyer R

    更新日期：1985-04-16 00:00:00

  • Allele specific gain-of-function activity of p53 mutants in lung cancer cells.

    abstract：:p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with "gain of function" (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different endogenous p53 muta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.09.029

    authors： Vaughan CA,Frum R,Pearsall I,Singh S,Windle B,Yeudall A,Deb SP,Deb S

    更新日期：2012-11-09 00:00:00

  • A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts.

    abstract：:The ubiquitously expressed Calpains 1 and 2 belong to a family of calcium-dependent intracellular cysteine proteases. Both calpains are heterodimers consisting of a large subunit and a small regulatory subunit encoded by the gene Capns1. To investigate a role for the calpain small subunit in cells of the osteoblast li...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.134

    authors： Kashiwagi A,Fein MJ,Shimada M

    更新日期：2011-06-03 00:00:00

  • Isolation and characterization of (+)-1,1a-dihydroxy-1-hydrofluoren-9-one formed by angular dioxygenation in the bacterial catabolism of fluorene.

    abstract：:Transformation of fluorene by washed cells of fluorene-grown Pseudomonas sp. F274 yielded 1,la-dihydroxy-1-hydrofluoren-9-one (up to 100 mg/l) as the stable product of angular dioxygenation of 9-fluorenone. Structural identity of the angular keto-diol was established by 13C- and 1H-NMR, gas chromatography- and direct ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1591

    authors： Selifonov SA,Grifoll M,Gurst JE,Chapman PJ

    更新日期：1993-05-28 00:00:00

  • Identification of a region critical for proteolysis of the human growth hormone receptor.

    abstract：:Release of soluble growth hormone binding protein (GHBP) corresponding to the extracellular domain of the GH receptor (GHR) occurs via distinct mechanisms depending on species. In human, proteolysis of full length GHR results in liberation of GHBP into the extracellular medium. A putative protease responsive for GHR c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6261

    authors： Conte F,Salles JP,Raynal P,Fernandez L,Molinas C,Tauber M,Bieth E

    更新日期：2002-01-18 00:00:00

  • Type II phospholipase A2 recombinant overexpression enhances stimulated arachidonic acid release.

    abstract：:The coding sequence of type II phospholipase A2 from human placenta was cloned in a bovine papilloma virus-derived eukaryotic expression vector under the control of the metallothionein promoter. Stably transfected C127 mouse fibroblast lines were obtained with this vector. These transfected cells overexpressed a funct...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91035-b

    authors： Pernas P,Masliah J,Olivier JL,Salvat C,Rybkine T,Bereziat G

    更新日期：1991-08-15 00:00:00

  • Molecular cloning and sequence analysis of cDNA for human transferrin.

    abstract：:A cDNA clone for human transferrin was identified from a human liver cDNA library by pre-screening with different ss-cDNA probes against length-fractionated liver mRNAs, positive hybridization-selection and nucleotide sequence analysis. The insert was of 1 kb, encoding human transferrin from aminoacid 403 through the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91648-6

    authors： Uzan G,Frain M,Park I,Besmond C,Maessen G,Trépat JS,Zakin MM,Kahn A

    更新日期：1984-02-29 00:00:00

  • Identification of a lysophosphatidylserine receptor on mast cells.

    abstract：:Lysophosphatidyl-L-serine (lysoPS) is thought to be an immunological regulator because it dramatically augments the degranulation of rat peritoneal mast cells (RPMCs). This stimulatory effect may be mediated by a lysoPS receptor, but its molecule has not been identified yet. During a ligand fishing study for the orpha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.01.069

    authors： Sugo T,Tachimoto H,Chikatsu T,Murakami Y,Kikukawa Y,Sato S,Kikuchi K,Nagi T,Harada M,Ogi K,Ebisawa M,Mori M

    更新日期：2006-03-24 00:00:00

  • Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells.

    abstract：:We have used human neuroblastoma NB-OK1 cells to investigate the regulation of neurite outgrowth. Carbachol suppressed forskolin-stimulated neurite outgrowth in NB-OK1 cells although forskolin-stimulated cAMP levels were enhanced. The dose-response curve for this suppression was very similar to that for stimulation of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80110-x

    authors： Nakagawa-Yagi Y,Saito Y,Takada Y,Nakamura H

    更新日期：1992-01-15 00:00:00

  • microRNA-222 modulates liver fibrosis in a murine model of biliary atresia.

    abstract：:microRNA-222 (miR-222) has been shown to initiate the activation of hepatic stellate cells, which plays an important role in the pathogenesis of liver fibrosis. The aim of our study was to evaluate the role of miR-22 in a mouse model of biliary atresia (BA) induced by Rhesus Rotavirus (RRV) infection. New-born Balb/c ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.02.065

    authors： Shen WJ,Dong R,Chen G,Zheng S

    更新日期：2014-03-28 00:00:00

  • ATR microspectroscopy with multivariate analysis segregates grades of exfoliative cervical cytology.

    abstract：:Although cervical cancer screening in the UK has led to reductions in the incidence of invasive disease, this programme remains flawed. We set out to examine the potential of infrared (IR) microspectroscopy to allow the profiling of cellular biochemical constituents associated with disease progression. Attenuated tota...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.005

    authors： Walsh MJ,Singh MN,Pollock HM,Cooper LJ,German MJ,Stringfellow HF,Fullwood NJ,Paraskevaidis E,Martin-Hirsch PL,Martin FL

    更新日期：2007-01-05 00:00:00

  • TGF-beta 1 modulated the expression of alpha 5 beta 1 integrin and integrin-mediated signaling in human hepatocarcinoma cells.

    abstract：:Integrins are a family of cell surface adhesion molecules which mediate cell adhesion and initiate signaling pathways that regulate cell spreading, migration, differentiation, and proliferation. TGF-beta is a multifunctional factor that induces a wide variety of cellular processes. In this study, we show that, TGF-bet...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3177

    authors： Cai T,Lei QY,Wang LY,Zha XL

    更新日期：2000-08-02 00:00:00

  • Enhancement of TNF-alpha-induced apoptosis by immobilized arginine-glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism.

    abstract：:Extracellular matrix facilitates anchorage-dependent cell survival via interaction of its arginine-glycine-aspartate (RGD) motif with integrins. In this report, we describe an unexpected, apoptosis-promoting the effect of immobilized RGD (iRGD) on tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. Mesangial ce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3654

    authors： Moreno-Manzano V,Lucio-Cazana J,Konta T,Nakayama K,Kitamura M

    更新日期：2000-10-22 00:00:00

  • Reduced secretion and expression of gelatinase profile in Toxoplasma gondii-infected human monocytic cells.

    abstract：:The apicomplexan Toxoplasma gondii, an obligate intracellular parasite, can infect humans and a wide range of vertebrates. Following oral infection, the parasite invades tissues by crossing non-permissive biological barriers such as the placenta or the blood-brain barrier. But the molecular mechanisms underlying migra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.089

    authors： Buache E,Garnotel R,Aubert D,Gillery P,Villena I

    更新日期：2007-07-27 00:00:00

  • Binding specificity of lung surfactant protein SP-D for glucosylceramide.

    abstract：:The specificities of the binding of lung surfactant protein SP-D to glycolipids were examined using 125I-labeled SP-D as a probe. When the binding study was performed on TLC plates, SP-D bound exclusively to GlcCer, whereas it failed to bind to GalCer, GM1, GM2, asialo-GM1, asialo-GM2, sulfatide, Forssman antigen, cer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91291-w

    authors： Kuroki Y,Gasa S,Ogasawara Y,Shiratori M,Makita A,Akino T

    更新日期：1992-09-16 00:00:00

  • Nuclear localization signals in the core protein of hepatitis C virus.

    abstract：:The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of the HCV core and its beta-galactosidase fusion proteins in transfected cells were examined by indirect immunofluorescence and cyt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2804

    authors： Chang SC,Yen JH,Kang HY,Jang MH,Chang MF

    更新日期：1994-12-15 00:00:00

  • Differences in mitogenic responses to angiotensin II, calf serum and phorbol ester in vascular smooth muscle cells from two strains of genetically hypertensive rat.

    abstract：:Vascular smooth muscle cells cultured from spontaneously hypertensive (SHR), New Zealand genetically hypertensive (GH) rat strains and their control strains (Wistar-Kyoto (WKY) and normal Wistar (N) rats) were compared for mitogenic responses [( 3H]-thymidine incorporation) to angiotensin II (AII), fetal calf serum (F...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90528-u

    authors： Harris EL,Grigor MR,Millar JA

    更新日期：1990-08-16 00:00:00

  • Enhancement of GTP gamma S-binding activity by cAMP-dependent phosphorylation of a filamin-like 250 kDa membrane protein in human platelets.

    abstract：:The treatment of human platelets with the dibutyryl cyclic AMP (dbcAMP) revealed the presence of a 250 kDa protein which enhanced its GTP-binding activity. This protein was purified from platelet membranes by successive chromatographies on DEAE-cellulose, Ultrogel AcA34, Mono Q, HCA-hydroxyapatite, and TSK-3000SW colu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80202-5

    authors： Yada Y,Okano Y,Nozawa Y

    更新日期：1990-10-15 00:00:00