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Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus.

Abstract：

:Flavivirus non-structural protein 4A (NS4A) induces membrane rearrangements to form viral replication complex and functions as interferon antagonist. However, other non-structural roles of NS4A protein in relation to virus life-cycle are poorly defined. This study elucidated if dengue virus (DENV) NS4A protein interacts with host proteins and contributes to viral pathogenesis by screening human liver cDNA yeast-two-hybrid library. Our study identified polypyrimidine tract-binding protein (PTB) as a novel interacting partner of DENV NS4A protein. We reported for the first time that PTB influenced DENV production. Gene-silencing studies showed that PTB did not have an effect on DENV entry and DENV RNA translation. Further functional studies revealed that PTB influenced DENV production by modulating negative strand RNA synthesis. This is the first study that enlightens the interaction of DENV NS4A protein with PTB, in addition to demonstrating the novel role of PTB in relation to mosquito-borne flavivirus life-cycle.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Jiang L,Yao H,Duan X,Lu X,Liu Y

doi

10.1016/j.bbrc.2009.05.036

subject

Has Abstract

pub_date

2009-07-24 00:00:00

pages

187-92

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00957-7

journal_volume

385

pub_type

杂志文章

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