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Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apo-A-I.

Abstract：

:Lp-A-I was isolated by immunoaffinity chromatography and then separated into two fractions of large and small Lp-A-I particles by conventional ultracentrifugation with a cut-off density of 1.125 g/ml. The large and small particle-rich fractions were then radiolabeled with [125I]-Na and [131I]-Na, respectively. Both of the labeled lipoproteins were injected (20 microCi, i.v.) simultaneously into normolipidemic rabbits. The FCR of the large Lp-A-I particles was much less than that of the small Lp-A-I particles (0.801 +/- 0.026/day vs. 2.227 +/- 0.067/day, P < 0.0001). These data indicate that the two particles have distinctly different metabolic pathways and that the lower FCR of larger Lp-A-I particles can effectively raise plasma HDL levels.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Saku K,Liu R,Ohta T,Jimi S,Matsuda I,Arakawa K

doi

10.1006/bbrc.1994.1484

subject

Has Abstract

pub_date

1994-04-15 00:00:00

pages

557-61

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71484-7

journal_volume

200

pub_type

杂志文章

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