当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Identification of a novel positive regulator of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.

Identification of a novel positive regulator of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.

Abstract：

:The hpa cluster of Escherichia coli W ATCC 11105 encodes the enzymes involved in the catabolism of 4-hydroxyphenylacetate (4-HPA). The catabolic genes are organized in two operons, the hpaBC operon, which produces the hydroxylase activity, and the meta operon, which encodes the enzymes that cleave the aromatic ring and allows its further metabolism. Using a monocopy or multicopy lacZ reporter system, we have demonstrated that the hydroxylase genes are transcribed from the PBC promoter which is positively regulated by the hpaA gene product. HpaA is activated by 4-HPA, 3-HPA, or phenylacetate and represents a novel member of the AraC/XylS family of regulators that recognizes aromatic effectors. The -35 box of the PBC promoter clearly deviates from the consensus sigma 70 promoters of E. coli, but upstream of this box we observed two direct repeats, a common characteristic of promoters regulated by the AraC family of proteins. The hpaA gene, which appears to form a transcriptional unit with the putative hpaX transport gene, is also expressed from an alternative promoter that is located within the hpaX structural sequence. On the basis of these findings, we propose a working model for the regulation of the unique aromatic catabolic pathway thus far characterized at a molecular level in E. coli. This regulatory circuit opens a new scenario for the development of novel microbiological tools for environmental purposes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Prieto MA,García JL

doi

10.1006/bbrc.1997.6368

subject

Has Abstract

pub_date

1997-03-27 00:00:00

pages

759-65

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X97963683

journal_volume

232

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • ET-1 deletion from endothelial cells protects the kidney during the extension phase of ischemia/reperfusion injury.

    abstract：BACKGROUND:The prognosis of patients after acute kidney injury (AKI) is poor and treatment is limited. AKI is mainly caused by renal ischemia/reperfusion injury (IRI). During the extension phase of IRI, endothelial damage may participate in ischemia and inflammation. Endothelin-1 (ET-1) which is mostly secreted by endo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.121

    authors： Arfian N,Emoto N,Vignon-Zellweger N,Nakayama K,Yagi K,Hirata K

    更新日期：2012-08-24 00:00:00

  • Effect of interleukin-6 on cell proliferation of FRTL-5 cells.

    abstract：:We studied the effects of interleukin-6(IL-6) on DNA synthesis and cyclic AMP production in rat thyroid FRTL-5 cells. When cells were incubated with IL-6 in the presence or absence of IGF-I, cell proliferation was not observed. By contrast, IL-6 stimulated DNA synthesis in a dose dependent manner when TSH was added co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1416

    authors： Nishiyama S,Takada K,Tada H,Takano T,Amino N

    更新日期：1993-04-15 00:00:00

  • Identification of a complement receptor 1 peptide for inhibition of immune hemolysis.

    abstract：:Complement sensitization of red blood cells (RBCs) can cause life-threatening hemolytic anemias. We have previously shown that complement receptor 1 (CR1) derivatives specifically the N-terminal region with decay accelerating activity (DAA) for inactivation of a key enzyme in the complement cascade can reduce compleme...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.020

    authors： Yu J,Heck S,Debnath A,Yazdanbakhsh K

    更新日期：2007-02-09 00:00:00

  • Histone H1-stimulated phosphorylase phosphatase from rabbit skeletal muscle.

    abstract：:A major rabbit skeletal muscle phosphorylase phosphatase activity which is markedly stimulated by histone H1 has been resolved from inhibitor-sensitive phosphorylase phosphatase (type-1 phosphatase), glycogen synthase kinase 3-activated phosphatase, phosphatase heat-stable inhibitor proteins, and alkaline phosphatase ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91228-7

    authors： Mellgren RL,Schlender KK

    更新日期：1983-12-16 00:00:00

  • Phosphorylation of protamines by protein kinase C: involvement of sites which are phosphorylated in vivo and are not affected by cAMP-dependent protein kinase.

    abstract：:Most fish protamines contain two phosphorylatable sites both of which incorporate phosphate in vivo. Here we show that in two protamines (salmine A1 and clupeine Y1) the site more distant from the N-terminus (residues 20-21) is unaffected by cAMP-dependent protein kinase while it represents the main target for protein...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91455-0

    authors： Ferrari S,Pinna LA

    更新日期：1987-05-14 00:00:00

  • Matrix vesicles and media vesicles as nonclassical pathways for the secretion of m-Calpain from MC3T3-E1 cells.

    abstract：:Calpain was generally believed to exist and function only in the cytoplasm. However, m-calpain has now been detected in the extracellular spaces of some kinds of tissue. In this study, we demonstrated the existence of m-calpain in the medium surrounding MC3T3-E1 cultures, and its activity by zymography. At the same ti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5242

    authors： Nishihara H,Nakagawa Y,Ishikawa H,Ohba M,Shimizu K,Nakamura T

    更新日期：2001-07-20 00:00:00

  • Characterization of the enzymatic mechanism of gamma-momorcharin, a novel ribosome-inactivating protein with lower molecular weight of 11,500 purified from the seeds of bitter gourd (Momordica charantia).

    abstract：:The enzymatic mechanism of a small ribosome-inactivating protein, gamma-momorcharin, purified from the seeds of Momordica charantia, has been characterized. By SDS-polyacrylamide and electrospray ionization mass spectrometry, its molecular weight was measured to be 11,500 daltons which is much lower than other RIPs kn...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1794

    authors： Pu Z,Lu BY,Liu WY,Jin SW

    更新日期：1996-12-04 00:00:00

  • Picrotoxin is a CYP1A1 inducer in rainbow trout hepatocytes.

    abstract：:Picrotoxin is a CYP2B inducer in mammals (1). However, in primary cultures of rainbow trout hepatocytes we showed CYP1A1 gene expression to be strongly induced as characterized by 7-ethoxyresorufin-O-deethylase activity, immunoblots of CYP1A1 protein, and Northern blots of CYP1A1 mRNA. Induction of CYP1A1 in these cel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2393

    authors： Sadar MD,Ash R,Andersson TB

    更新日期：1995-09-25 00:00:00

  • Expression of HIV-1 envelope glycoprotein alters cellular calmodulin.

    abstract：:Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity. We investigated whether expression of full length gp160 would result in changes in intracellular calmodulin compared to expression of gp160 truncated to remove both known c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0034

    authors： Radding W,Pan ZQ,Hunter E,Johnston P,Williams JP,McDonald JM

    更新日期：1996-01-05 00:00:00

  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization.

    abstract：:Ras proteins can be modified at their COOH-terminal cysteine in the motif Cys-Ali-Ali-Xaa by a farnesyl isoprenoid. This modification is essential for membrane association and biological activity of ras proteins. A similar COOH-terminal amino acid sequence, Cys-Xaa-Ali-Xaa, exists in the ras-related GTP-binding protei...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91217-g

    authors： Didsbury JR,Uhing RJ,Snyderman R

    更新日期：1990-09-14 00:00:00

  • Coordinated downregulation of KCC2 and GABAA receptor contributes to inhibitory dysfunction during seizure induction.

    abstract：:The GABAA receptor (GABAAR) is the main inhibitory receptor in the adult mammalian brain. GABAAR function is dependent on its expression, distribution, and the chloride (Cl-) transmembrane gradient, which is determined by the potassium-chloride cotransporter 2 (KCC2) in the adult brain. KCC2 and GABAAR are downregulat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.08.082

    authors： Wan L,Chen L,Yu J,Wang G,Wu Z,Qian B,Liu X,Wang Y

    更新日期：2020-11-12 00:00:00

  • Two domains of the epidermal growth factor receptor are involved in cytoskeletal interactions.

    abstract：:Epidermal growth factor receptor can interact directly with F-actin through an actin-binding domain. In the present study, a mutant EGFR, lacking a previously identified actin-binding domain (ABD 1), was still able to bind elements of the cytoskeleton. A second EGFR actin-binding domain (ABD 2) was identified in the r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.138

    authors： Song W,Wu J,Ge G,Lin Q

    更新日期：2008-06-13 00:00:00

  • Immunochemical demonstration of a novel beta-subunit isoform of X, K-ATPase in human skeletal muscle.

    abstract：:Recently we have identified mRNA encoding a hitherto unknown mammalian X,K-ATPase beta-subunit expressed predominantly in muscle tissue (Pestov, N. B. et al. (1999) FEBS Lett. 456, 243-248). Here we demonstrate the existence of the predicted protein, designated as beta(m) (beta(muscle)), in human adult skeletal muscle...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3692

    authors： Pestov NB,Korneenko TV,Zhao H,Adams G,Shakhparonov MI,Modyanov NN

    更新日期：2000-10-22 00:00:00

  • Calcium release associated with discharge of specific granule contents from human neutrophils.

    abstract：:Neutrophil discharge of calcium into the ambient medium was measured, using an ion-sensitive electrode, after cells were stimulated with phorbol myristate acetate. Dose-dependent calcium efflux was observed over the same range of stimulus concentrations associated with specific granule marker release. Calcium efflux w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90282-3

    authors： Styrt B,Schwartz MA,Klempner MS

    更新日期：1988-08-15 00:00:00

  • PB1 and UBA domains of p62 are essential for aggresome-like induced structure formation.

    abstract：:ALIS are large, transient, cytosolic aggregates that serve as storage compartments for ubiquitin-tagged defective ribosomal products. We determined the importance of the protein p62 in the formation of ALIS and demonstrated that two domains of p62-PB1 and UBA-are essential for ALIS assembly. Those two major binding do...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.153

    authors： Cabe M,Rademacher DJ,Karlsson AB,Cherukuri S,Bakowska JC

    更新日期：2018-09-18 00:00:00

  • Retracted: Apoptosis of CT26 colorectal cancer cells induced by Clostridium difficile toxin A stimulates potent anti-tumor immunity.

    abstract：:Clostridium difficile toxin A (TcdA) is one of the main pathogenic factors released by C. difficile. Due to its potent cytotoxic and proinflammatory activities, we investigated the anti-tumor activity of TcdA. CT26 colorectal cancer cells were challenged with recombinant TcdA, and it was found that TcdA could induce a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.bbrc.2012.04.068

    authors： Tian Y,Huang T,Li G,Liu J,Wang X,Feng H,Wang J

    更新日期：2012-05-25 00:00:00

  • An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma.

    abstract：:Alveolar rhabdomyosarcoma (aRMS) is a very aggressive sarcoma of children and young adults. Our previous studies have shown that small molecule inhibition of Pdgfra is initially very effective in an aRMS mouse model. However, slowly evolving, acquired resistance to a narrow-spectrum kinase inhibitor (imatinib) was com...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.08.092

    authors： Abraham J,Chua YX,Glover JM,Tyner JW,Loriaux MM,Kilcoyne A,Giles FJ,Nelon LD,Carew JS,Ouyang Y,Michalek JE,Pal R,Druker BJ,Rubin BP,Keller C

    更新日期：2012-09-28 00:00:00

  • Rapid synthesis of DNA-cysteine conjugates for expressed protein ligation.

    abstract：:We report a rapid method for the covalent modification of commercially available amino-modified DNA oligonucleotides with a cysteine moiety. The resulting DNA-cysteine conjugates are versatile reagents for the efficient preparation of covalent DNA-protein conjugates by means of expressed protein ligation (EPL). The EP...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.001

    authors： Lovrinovic M,Niemeyer CM

    更新日期：2005-09-30 00:00:00

  • Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK.

    abstract：:Acetyl-CoA carboxylases (ACCs) have been highlighted as therapeutic targets for obesity and diabetes, as they play crucial roles in fatty acid metabolism. ACC activity is regulated through the short-term mechanism of inactivation by reversible phosphorylation. Here, we report the crystal structures of the biotin carbo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.11.029

    authors： Cho YS,Lee JI,Shin D,Kim HT,Jung HY,Lee TG,Kang LW,Ahn YJ,Cho HS,Heo YS

    更新日期：2010-01-01 00:00:00

  • Software for precise tracking of cell proliferation.

    abstract：:We have developed a multi-target cell tracking program TADOR, which we applied to a series of fluorescence images. TADOR is based on an active contour model that is modified in order to be free of the problem of locally optimal solutions, and thus is resistant to signal fluctuation and morphological changes. Due to ad...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.12.100

    authors： Kurokawa H,Noda H,Sugiyama M,Sakaue-Sawano A,Fukami K,Miyawaki A

    更新日期：2012-01-20 00:00:00

  • RNA mutations of prox1 detected in human esophageal cancer cells by the shifted termination assay.

    abstract：:We have recently reported a novel finding that a candidate tumor suppressor gene prox1 suffered adenosine-to-inosine (A-to-I) RNA mutation without genomic mutation in a subset of human cancer cells and lost its function. Hence, screening of mutations in both cDNA and genomic DNA could be important in the analysis of c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.071

    authors： Yoshimoto T,Takahashi M,Nagayama S,Watanabe G,Shimada Y,Sakasi Y,Kubo H

    更新日期：2007-07-27 00:00:00

  • The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.

    abstract：:Heterogeneity in transmissible spongiform encephalopathy is thought to have derived from conformational variation in an abnormal isoform of the prion protein (PrPSc). To characterize PrPSc in bovine spongiform encephalopathy (BSE) and scrapie, we analyzed the newly generated N-terminus of PrPSc isoforms by digestion w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.065

    authors： Hayashi HK,Yokoyama T,Takata M,Iwamaru Y,Imamura M,Ushiki YK,Shinagawa M

    更新日期：2005-03-25 00:00:00

  • Long non-coding RNA HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma.

    abstract：:Gastric cancer is one of the major causes of cancer death worldwide; however, the mechanism of carcinogenesis is complex and poorly understood. Long non-coding RNA HOTAIR (HOX transcript antisense RNA) recently emerged as a promoter of metastasis in various cancers including gastric cancer. Here we investigated the im...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.07.067

    authors： Lee NK,Lee JH,Park CH,Yu D,Lee YC,Cheong JH,Noh SH,Lee SK

    更新日期：2014-08-22 00:00:00

  • Reduced expression of Bax in ceramide-resistant HL-60 subline.

    abstract：:Ceramide, the backbone of sphingolipids, has been reported to be involved in various cellular responses including apoptosis. We recently established and characterized a C2-ceramide-resistant HL-60 subline designated HL-CR. HL-CR cells were resistant to not only ceramide but also anti-cancer drugs including daunorubici...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.152

    authors： Sawai H,Kawai S,Domae N

    更新日期：2004-06-18 00:00:00

  • Ectopical expression of FABP4 gene can induce bovine muscle-derived stem cells adipogenesis.

    abstract：:Fatty acid binding protein 4 (FABP4) plays a key role in Fatty acid catabolism in mammals. Findings from our previous studies have indicated that FABP4 neither affect the differentiation of bovine preadipocytes nor does it change the expression of upstream genes. To investigate whether ectopically expressed FABP4 can ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.11.067

    authors： Zhang L,Zhao Y,Ning Y,Wang H,Zan L

    更新日期：2017-01-08 00:00:00

  • TPA activates p21WAF-1 promoter in human T-cells through its second most upstream Sp1 site.

    abstract：:The p21(WAF-1) promoter contains binding sites for a number of transcription factors which mediate its activation by a variety of external signals. Moreover, it has been reported that the transcription factors involved in p21(WAF-1) activation by certain signaling factors, like the phorbol ester TPA, may vary in diffe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00650-8

    authors： Schavinsky-Khrapunsky Y,Huleihel M,Aboud M,Torgeman A

    更新日期：2003-05-16 00:00:00

  • On the specificity of a bacteriophage-borne endoglycanase for the native capsular polysaccharide produced by Klebsiella pneumoniae SK1 and its derived polymers.

    abstract：:The specificity of the endoglycanase associated with the bacteriophage phi SK1 particles was tested on the native capsular polysaccharide produced by Klebsiella pneumoniae serotype SK1 and on three chemically modified polymers derived from it. The primary structure of the SK1 capsular polysaccharide is: [formula: see ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1160

    authors： Cescutti P,Paoletti S

    更新日期：1994-02-15 00:00:00

  • NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes.

    abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is involved in DNA repair and activated by DNA damage. When activated, PARP-1 consumes NAD(+) to form ADP-ribose polymers on acceptor proteins. Extensive activation of PARP-1 leads to glycolytic blockade, energy failure, and cell death. These events have ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01483-9

    authors： Ying W,Garnier P,Swanson RA

    更新日期：2003-09-05 00:00:00

  • Insoluble matrix components of glioma cells suppress LPS-mediated iNOS/NO induction in microglia.

    abstract：:This study examines the influence of insoluble matrix components of glioma (astrocytoma) cells on LPS-mediated inducible nitric oxide (NO)/NO synthase (iNOS) induction in microglia cells. Insoluble matrix components prepared from C6 rat glioma cells strongly suppressed iNOS induction and subsequent NO release induced ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.149

    authors： Kim YJ,Hwang SY,Han IO

    更新日期：2006-09-01 00:00:00

  • Systemic identification of estrogen-regulated genes in breast cancer cells through cap analysis of gene expression mapping.

    abstract：:To explore the estrogen-regulated genes genome-widely in breast cancer, cap analysis of gene expression (CAGE) sequencing was performed in MCF-7 cells under estrogen treatment. Estrogen-regulated expressional changes were found in 1537 CAGE tag clusters (TCs) (⩾1.5 or ⩽0.66-folds). Among them, 15 TCs were situated in ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.04.033

    authors： Yamaga R,Ikeda K,Boele J,Horie-Inoue K,Takayama K,Urano T,Kaida K,Carninci P,Kawai J,Hayashizaki Y,Ouchi Y,de Hoon M,Inoue S

    更新日期：2014-05-09 00:00:00