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Effect of interleukin-6 on cell proliferation of FRTL-5 cells.

Abstract：

:We studied the effects of interleukin-6(IL-6) on DNA synthesis and cyclic AMP production in rat thyroid FRTL-5 cells. When cells were incubated with IL-6 in the presence or absence of IGF-I, cell proliferation was not observed. By contrast, IL-6 stimulated DNA synthesis in a dose dependent manner when TSH was added concomitantly. On the other hand, IL-6 did not modulate the cAMP accumulation in the presence or absence of TSH. These data demonstrate that, like IGF-I, IL-6 may be able to act as a growth factor through activation of a mitogenic signal transduction pathway different from A-kinase in FRTL-5 cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nishiyama S,Takada K,Tada H,Takano T,Amino N

doi

10.1006/bbrc.1993.1416

subject

Has Abstract

pub_date

1993-04-15 00:00:00

pages

319-23

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71416-6

journal_volume

192

pub_type

杂志文章

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