Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats.

abstract：:Mutations in the GDD1 gene cause gnathodiaphyseal dysplasia, a rare human skeletal syndrome with autosomal dominant inheritance. The biochemical function(s) of GDD1 protein and the molecular pathophysiology of GDD1 mutations leading to GDD have not yet been elucidated. In this study, we characterized the complete cDNA...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumi S,Inoue H,Sakamoto Y,Mizuta K,Kamata N,Itakura M

更新日期：2005-06-17 00:00:00

abstract：:DNase coatings show great potential to prevent biofilm formation in various applications of the medical implant, food and marine industry. However, straightforward and quantitative methods to characterize the enzymatic activity of these coatings are currently not available. We here introduce the qDNase assay, a quanti...

journal_title：Biochemical and biophysical research communications

authors： Van der Gucht M,Aktan MK,Hendrix H,Velde GV,Paeshuyse J,Braem A,Lavigne R

更新日期：2021-01-01 00:00:00

abstract：:Prion protein (PrPc) is expressed in many tissues, both in human and animals. The scrapie isoform of PrPc has been shown to cause neurodegeneration. In other studies it has been demonstrated that overexpression of the PrP gene can result in nonneuronal tissue degradation. Little is known, however, about the normal fun...

journal_title：Biochemical and biophysical research communications

authors： Kniazeva M,Orman R,Terranova VP

更新日期：1997-05-08 00:00:00

abstract：:We have already cloned the cDNA for the HPC-1 antigen, a neuron-specific protein antigen from the rat brain. Here we report the molecular cloning of the bovine HPC-1 antigen homologue, and much strong sequence conservation between rat and bovine. By searching the recent protein data base, it was found that the HPC-1 a...

journal_title：Biochemical and biophysical research communications

authors： Inoue A,Akagawa K

更新日期：1992-09-16 00:00:00

abstract：:Multidrug resistance (MDR) is a unique phenomenon in cancer patients and is commonly associated with an overexpression of the human MDR gene mdr1, which encodes an energy-dependent Mr 180 kDa membrane bound protein, known as P-glycoprotein. P-glycoprotein serves as a membrane efflux to pump the drugs out of the cancer...

journal_title：Biochemical and biophysical research communications

authors： Chu TM,Lin TH,Kawinski E

更新日期：1994-08-30 00:00:00

abstract：:The hyperpolarization-activated cation current I(h) is an important regulator of neuronal excitability and may contribute to the properties of the dentate gyrus granule (DGG) cells, which constitute the input site of the canonical hippocampal circuit. Here, we investigated changes in I(h) in DGG cells in human tempora...

journal_title：Biochemical and biophysical research communications

authors： Surges R,Kukley M,Brewster A,Rüschenschmidt C,Schramm J,Baram TZ,Beck H,Dietrich D

更新日期：2012-03-30 00:00:00

abstract：:Signal transduction activity was markedly elevated in cancer cells as shown by the increased activity of enzymes utilizing 1-phosphatidylinositol, PI (PI 4-kinase and PI-4-phosphate 5-kinase) for the production of the second messenger inositol 1,4,5-trisphosphate, IP3, in rat hepatomas (Cancer Res. 54: 2611;5574, 1994...

journal_title：Biochemical and biophysical research communications

authors： Singhal RL,Yeh YA,Praja N,Olah E,Sledge GW Jr,Weber G

更新日期：1995-03-08 00:00:00

abstract：:Homeobox gene expression in osteoblast-like cells was investigated using the polymerase chain reaction (PCR). A total of 13 homeobox genes was detected in U-2 OS (human osteosarcoma) and MC3T3-E1 (mouse osteoblast) cells by sequencing cloned PCR products. Using specific primers, a different pattern of Hox gene express...

journal_title：Biochemical and biophysical research communications

authors： Kloen P,Visker MH,Olijve W,van Zoelen EJ,Boersma CJ

更新日期：1997-04-17 00:00:00

abstract：:Despite the fact that the phosphorylation-mediated regulation of L-type Ca channels is viewed as a model of ion channel regulation, much remains to be learned about the protein phosphorylation and dephosphorylation reactions that underlie the regulation of the channels. The channel isoform most well studied biochemica...

journal_title：Biochemical and biophysical research communications

authors： Zhao XL,Gutierrez LM,Chang CF,Hosey MM

更新日期：1994-01-14 00:00:00

abstract：:A potent analog (HNG) of the endogenous peptide humanin protects against myocardial ischemia-reperfusion (MI-R) injury in vivo, decreasing infarct size and improving cardiac function. Since oxidative stress contributes to the damage from MI-R we tested the hypotheses that: (1) HNG offers cardioprotection through activ...

journal_title：Biochemical and biophysical research communications

authors： Klein LE,Cui L,Gong Z,Su K,Muzumdar R

更新日期：2013-10-18 00:00:00

abstract：:4-Nonylphenol (NP) is reported to have estrogenic activity; however, its influence on cytokine production or immune system function remains unclear. In this study we investigated the effects of NP on the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha), and on the level of inducible nitric o...

journal_title：Biochemical and biophysical research communications

authors： You HJ,Choi CY,Jeon YJ,Chung YC,Kang SK,Hahm KS,Jeong HG

更新日期：2002-06-21 00:00:00

abstract：:Loss of CRY2 confers aggressive phenotypes to breast cancer. However, the mechanism of its downregulation and its prognostic value in breast cancer are still not clear. Our data mining in TCGA breast cancer cohort (TCGA-BRCA) showed that the luminal A subtype of breast cancer had the highest CRY2 expression, while the...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Shen H,Wang Y

更新日期：2017-08-12 00:00:00

abstract：:MUC1 is abundantly expressed at the surface of epithelial cells in many tissues and their carcinomas. In humans, genetic polymorphism and differential splicing produce isoforms that may contribute to MUC1 participation in protection of the cell surface, modulation of cell-cell interactions, signaling, and metastasis. ...

journal_title：Biochemical and biophysical research communications

authors： Julian J,Carson DD

更新日期：2002-05-17 00:00:00

abstract：:We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E2F-bindi...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Kang JK,Kim YK,Seo DW,Ahn SH,Lee JC,Lee CH,You JS,Cho EJ,Lee HW,Han JW

更新日期：2006-04-21 00:00:00

abstract：:Brefeldin A (BFA), an endoplasmic reticulum (ER)-Golgi transport inhibitor, has been shown to cause accumulation of proteins in the ER, ER stress, and ultimately apoptosis. In this paper, we demonstrate that the knockdown of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm), a mitochondrial NADPH-generat...

journal_title：Biochemical and biophysical research communications

authors： Moon JL,Kim SY,Shin SW,Park JW

更新日期：2012-01-13 00:00:00

abstract：:Phosphate transporters (PHTs) are well-known for their roles in phosphate uptake in plants. However, their actions in imparting plant growth in plants are still not so clear. In our previous study, we observed that maize PHT1 gene ZmPt9 plays a significant role in phosphate uptake. In this study, we further characteri...

journal_title：Biochemical and biophysical research communications

authors： Xu Y,Bao H,Fei H,Zhou W,Li X,Liu F

更新日期：2020-09-19 00:00:00

abstract：:The Shank family comprises three large multi-domain proteins playing central roles as protein scaffolds in the neuronal postsynaptic density. The Shank proteins are closely linked to neuropsychiatric diseases, such as autism spectrum disorders. One characteristic domain in the Shank family is the SH3 domain, assumed t...

journal_title：Biochemical and biophysical research communications

authors： Ponna SK,Myllykoski M,Boeckers TM,Kursula P

更新日期：2017-08-26 00:00:00

abstract：:The family of endothelins, endothelin-1 (ET-1), ET-2 and ET-3, act on two subtypes of receptors called ETA and ETB receptors. BQ123 is an ETA-selective competitive antagonist. In this study, however, BQ123 inhibited ET-1-induced transients of cytosolic Ca2+ concentrations ([Ca2+]i) in an apparently noncompetitive mann...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto A,Yanagisawa M,Tsujimoto G,Nakao K,Toyo-oka T,Masaki T

更新日期：1994-04-29 00:00:00

abstract：:X-ray microanalysis has been used to determine elemental content in the cytoplasm of hepatocytes of hyperthyroid rats in comparison with euthyroid controls. No significant differences were found for any examined element (sodium, phosphorus, sulfur, chlorine, potassium, magnesium and calcium). In contrast to earlier re...

journal_title：Biochemical and biophysical research communications

authors： Smith NK,Lewiński A,Stabler-Morris S

更新日期：1983-08-30 00:00:00

abstract：:The acute effects of 1,25-Dihydroxy-vitamin D3 [1,25(OH)2D3] on the concentration of cytoplasmic ionized calcium [Ca2+] of cultured rat mesangial cells were studied at the single cell level by microspectrofluorometry of fura-2-loaded cells. Addition of 1,25(OH)2D3 produced an immediate increase of [Ca2]+. This rise in...

journal_title：Biochemical and biophysical research communications

authors： Boland RL,de Boland AR,Nobiling R,Weinreich T,Ritz E

更新日期：1991-10-31 00:00:00

abstract：:Expression of the human beta-myosin heavy chain (beta MHC) gene was studied by transient assay in culture and in situ by direct injection of plasmids into adult rat hearts. In this report we describe a unique repressor region located -326/-309 (5'-TTGGTGGTCGTGGTCAGT-3') of the human beta MHC gene that is conserved amo...

journal_title：Biochemical and biophysical research communications

authors： Edwards JG,Bahl JJ,Flink I,Milavetz J,Goldman S,Morkin E

更新日期：1992-11-30 00:00:00

abstract：:Bone mass is controlled by a balance between bone resorption and formation by osteoclasts and osteoblasts, respectively. An imbalance between osteoblasts and osteoclasts increases the risk of osteoporosis and fractures. Although inhibition of osteoclasts is beneficial for preventing and treating osteoporosis, enhanced...

journal_title：Biochemical and biophysical research communications

authors： Bae SJ,Min YK,Hwang ES

更新日期：2017-05-27 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to be involved in the pathophysiological processes of pain. At present, the roles and mechanisms of miRNAs in neonatal repetitive pain are largely unknown. In our research, the expression of miR-140-3p was increased in premature infants who received repetitive painful stimuli since a...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Yin J,Chen X,Mao X,Xu J,Cheng R,Wu J

更新日期：2019-08-06 00:00:00

abstract：:Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microg...

journal_title：Biochemical and biophysical research communications

authors： Gejyo F,Yamada T,Odani S,Nakagawa Y,Arakawa M,Kunitomo T,Kataoka H,Suzuki M,Hirasawa Y,Shirahama T

更新日期：1985-06-28 00:00:00

abstract：:Osteosarcoma is a common metastatic bone cancer that predominantly develops in children and adolescents. Metastatic osteosarcoma remains associated with a poor prognosis; therefore, more effective anti-metastatic drugs are needed. Differentiation-inducing factor-1 (DIF-1), -2, and -3 are novel lead anti-tumor agents t...

journal_title：Biochemical and biophysical research communications

authors： Kubohara Y,Komachi M,Homma Y,Kikuchi H,Oshima Y

更新日期：2015-08-07 00:00:00

abstract：:GLAST and GLT-1 are the most abundant glutamate transporters in the CNS and protect neurons from glutamate neurotoxicity. Here, we investigated the role of GLAST in spinal nociceptive processing. GLAST protein expression was not altered after treatment of rats with either formalin or zymosan. Surprisingly, knock-down ...

journal_title：Biochemical and biophysical research communications

authors： Niederberger E,Schmidtko A,Coste O,Marian C,Ehnert C,Geisslinger G

更新日期：2006-07-28 00:00:00

abstract：:Apolipoprotein B (apoB) mRNA editing involves a site-specific cytidine to uridine transition catalyzed by the cytidine deaminase, APOBEC-1, in the context of and regulated by a multi-protein-containing editosome. ApoB mRNA editing in vivo is subject to tissue specific, developmental and metabolic regulation. We demons...

journal_title：Biochemical and biophysical research communications

authors： Van Mater D,Sowden MP,Cianci J,Sparks JD,Sparks CE,Ballatori N,Smith HC

更新日期：1998-11-18 00:00:00

abstract：:Blebbistatin was recently identified as a selective, cell-permeant inhibitor of myosin II. Because blebbistatin is likely to be used extensively with fluorescence imaging in studies of cytoskeletal dynamics, its compatibility with common excitation wavelengths was examined. Illumination of blebbistatin-treated bovine ...

journal_title：Biochemical and biophysical research communications

authors： Kolega J

更新日期：2004-07-30 00:00:00

abstract：:The myelin basic proteins (MBPs) are a family of polypeptides that are predominantly expressed in the nervous system where they play a major role in myelination. We have generated four lines of transgenic mice carrying a transgene in which 1.34 kb of the 5'-flanking sequence of the mouse MBP gene was fused upstream of...

journal_title：Biochemical and biophysical research communications

authors： Asipu A,Mellor AL,Blair GE

更新日期：2001-11-09 00:00:00

abstract：:Endothelin, a vasoconstrictor peptide, plays important roles not only in the mammalian circulatory system but also in non-mammalian systems, such as the gill lamellar vascular network with complex structural characteristics. Here, we show that (i) the contraction of pillar cells that delimit the lamellar vasculature i...

journal_title：Biochemical and biophysical research communications

authors： Sultana N,Nag K,Kato A,Hirose S

更新日期：2007-03-30 00:00:00