Detection of soluble P-glycoprotein in culture media and extracellular fluids.

abstract：:Cytochrome c3 (Mr 26,000) has been characterized in Desulfovibrio vulgaris (Hildenborough) and its properties compared with polyhemic cytochromes c isolated from the same organism and from D. desulfuricans (Norway). It can be described as an octaheme cytochrome c3 constituted of two identical subunits. Absorption spec...

journal_title：Biochemical and biophysical research communications

authors： Loutfi M,Guerlesquin F,Bianco P,Haladjian J,Bruschi M

更新日期：1989-03-15 00:00:00

abstract：:C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than alpha-human atrial natriuretic peptide (alpha-hANP). The inhibitory effect of CNP was mi...

journal_title：Biochemical and biophysical research communications

authors： Furuya M,Yoshida M,Hayashi Y,Ohnuma N,Minamino N,Kangawa K,Matsuo H

更新日期：1991-06-28 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Jiang J,Liu Y,Tang Y,Li L,Zeng R,Zeng S,Zhong M

更新日期：2016-12-03 00:00:00

abstract：:Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein gp130, which associates with the IL-6 receptor alpha chain (IL-6R alpha) in the presence of IL-6. We prepared monoclonal antibodies (mAbs) specific to murine gp130 by immunizing rats and hamsters with a chimeric molecule consisting of the extrac...

journal_title：Biochemical and biophysical research communications

authors： Matsuda T,Hirano T

更新日期：1994-07-15 00:00:00

abstract：:This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Rai V,Datta K

更新日期：2010-04-10 00:00:00

abstract：:Dengue Virus (DENV) infection is an important mosquito-borne viral disease and its clinical symptoms range from a predominantly febrile disease, dengue fever (DF), to dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Increased levels of cytokines - the so-called 'cytokine storm', contribute to the pathog...

journal_title：Biochemical and biophysical research communications

authors： Suttitheptumrong A,Khunchai S,Panaampon J,Yasamut U,Morchang A,Puttikhunt C,Noisakran S,Haegeman G,Yenchitsomanus PT,Limjindaporn T

更新日期：2013-06-28 00:00:00

abstract：:Animals and plants respond to bacterial infections and environmental stresses by inducing overlapping repertoires of defense genes. How the signals associated with infection and abiotic stresses are differentially integrated within a whole organism remains to be fully addressed. We show that the transcription of a Cae...

journal_title：Biochemical and biophysical research communications

authors： Kurz CL,Shapira M,Chen K,Baillie DL,Tan MW

更新日期：2007-11-16 00:00:00

abstract：:Previously we demonstrated that the histamine H2 receptor can activate both the adenylate cyclase and phosphoinositide/protein kinase (PKC) signaling pathways. Although dual coupling occurs via separate GTP-dependent mechanisms the structural components of the H2 receptor directing differential signaling have not been...

journal_title：Biochemical and biophysical research communications

authors： Wang LD,Gantz I,Butler K,Hoeltzel M,Del Valle J

更新日期：2000-09-24 00:00:00

abstract：:The biological function of hnRNP family proteins is widely diverse and involved in pre-mRNA processing, transcriptional regulation, recombination, and telomere maintenance. In the course of our study on the elucidation of biological functions of minisatellite DNA, we isolated several nuclear proteins that bind to the ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka E,Fukuda H,Nakashima K,Tsuchiya N,Seimiya H,Nakagama H

更新日期：2007-06-29 00:00:00

abstract：:Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The ...

journal_title：Biochemical and biophysical research communications

authors： Negoita F,Säll J,Morén B,Stenkula K,Göransson O

更新日期：2019-01-15 00:00:00

abstract：:TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) administered to young male guinea pigs at a dose of 1 microgram/kg (single intraperitoneal injection) caused a large reduction in adipose tissue lipoprotein lipase (LPL) activity. This effect occurred rapidly; a 70% decrease was noticed after 24 hour and 80% of LPL activity w...

journal_title：Biochemical and biophysical research communications

authors： Brewster DW,Matsumura F

更新日期：1984-07-31 00:00:00

abstract：:Melatonin produced by the pineal gland suppresses inflammatory responses in innate immune cells. However, the mechanism of how melatonin affects inflammatory gene regulation remains unclear. Here we performed comprehensive microarray analysis combined with transcription factor binding site (TFBS) analysis using LPS-in...

journal_title：Biochemical and biophysical research communications

authors： Kadena M,Kumagai Y,Vandenbon A,Matsushima H,Fukamachi H,Maruta N,Kataoka H,Arimoto T,Morisaki H,Funatsu T,Kuwata H

更新日期：2017-04-01 00:00:00

abstract：:We examined the expression of a Caenorhabditis elegans (C. elegans) elav-like gene, which we designated elr-1. The elr-1 gene encodes a predicted 456-amino-acid protein containing three putative RNA-binding domains and belongs to the ELAV family, which is functionally involved in neuronal differentiation. Northern blo...

journal_title：Biochemical and biophysical research communications

authors： Fujita M,Kawano T,Ohta A,Sakamoto H

更新日期：1999-07-14 00:00:00

abstract：:Kinetin (Kn) is a synthetic cytokinin plant growth hormone having some senescence-retarding effects in plants. Its effects on animal cells have been, until now, best considered as growth inhibitory and anti-tumorigenic. However, we have observed that an addition of 40-200 microM Kn in the culture medium of human diplo...

journal_title：Biochemical and biophysical research communications

authors： Rattan SI,Clark BF

更新日期：1994-06-15 00:00:00

abstract：:Hippocampal slices offer an excellent experimental system for the study of activity-induced changes in the postsynaptic density (PSD). While studies have documented electrophysiological and structural changes at synapses in response to precise manipulations of hippocampal slices, parallel biochemical and proteomic ana...

journal_title：Biochemical and biophysical research communications

authors： Dosemeci A,Tao-Cheng JH,Vinade L,Jaffe H

更新日期：2006-01-13 00:00:00

abstract：:Recently we have identified mRNA encoding a hitherto unknown mammalian X,K-ATPase beta-subunit expressed predominantly in muscle tissue (Pestov, N. B. et al. (1999) FEBS Lett. 456, 243-248). Here we demonstrate the existence of the predicted protein, designated as beta(m) (beta(muscle)), in human adult skeletal muscle...

journal_title：Biochemical and biophysical research communications

authors： Pestov NB,Korneenko TV,Zhao H,Adams G,Shakhparonov MI,Modyanov NN

更新日期：2000-10-22 00:00:00

abstract：:The insulin receptor gene is induced 8 to 10-fold during adipocyte differentiation. Plasmids containing the promoter, exon 1 and a portion of the first intron from either the mouse or human gene are able to modulate the expression of an insulin receptor/CAT gene 3 to 7-fold during differentiation. We have shown that s...

journal_title：Biochemical and biophysical research communications

authors： McKeon C,Accili D,Chen H,Pham T,Walker GE

更新日期：1997-11-26 00:00:00

abstract：:Complete nucleotide sequence of the genes for subunits of the H+ ATPase of E.coli has been determined and several hybrid plasmids carrying various portions of these genes have been constructed. Genetic complementation and recombination tests of about forty mutants of E.coli defective in the ATPase were performed using...

journal_title：Biochemical and biophysical research communications

authors： Noumi T,Kanazawa H

更新日期：1983-02-28 00:00:00

abstract：:Effects of growth hormone on morphology and cytoskeletal protein expression were examined in 3T3-F442A preadipocytes in serum-free medium. Between 2 and 5 days of culture 2 nM methionyl human growth hormone converted 3T3-F442A cells from a flat fibroblastic morphology to a rounded form with numerous membrane convoluti...

journal_title：Biochemical and biophysical research communications

authors： Guller S,Corin RE,Wu KY,Sonenberg M

更新日期：1989-09-15 00:00:00

abstract：:VEGF family members play important roles in angiogenesis and vascular permeability. VEGF-A-transgenic mice showed an increased vascularization with edema due to hyper-vascular permeability and subcutaneous hemorrhage as side effects. VEGF-A binds and activates two receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). To...

journal_title：Biochemical and biophysical research communications

authors： Kiba A,Sagara H,Hara T,Shibuya M

更新日期：2003-02-07 00:00:00

abstract：:The stability and catalytic efficacy of the L-2-haloacid dehalogenase isolated from Azotobacter sp. RC26 were studied after immobilisation on a DEAE Sephacel solid matrix. While the optimum temperature for the soluble dehalogenase falls in the range of 30-40 degrees C, the activity of the immobilised enzyme shows a fo...

journal_title：Biochemical and biophysical research communications

authors： Diez A,Prieto MI,Alvarez MJ,Bautista JM,Garrido J,Puyet A

更新日期：1996-03-27 00:00:00

abstract：:Myocardial fibrosis is the pathological consequence of injury-induced fibroblastto-myofibroblast transition, resulting in increased stiffness and diminished cardiac function. Histone modification has been shown to play an important role in the pathogenesis of cardiac fibrosis. Here, we identified H3K27me3 demethylase ...

journal_title：Biochemical and biophysical research communications

authors： Long F,Wang Q,Yang D,Zhu M,Wang J,Zhu Y,Liu X

更新日期：2020-08-06 00:00:00

abstract：:The Raf kinase inhibitor protein (RKIP) is a tumor suppressor that protects against metastasis and genomic instability. RKIP is downregulated in many types of tumors, although the mechanism for this remains unknown. MicroRNAs silence target genes via translational inhibition or target mRNA degradation, and are thus im...

journal_title：Biochemical and biophysical research communications

authors： Huang L,Dai T,Lin X,Zhao X,Chen X,Wang C,Li X,Shen H,Wang X

更新日期：2012-08-24 00:00:00

abstract：:Peptidyl fluoromethyl ketones, improved reagents for inactivating cysteinyl and serine proteinases, have provided unexpected results when applied to intact trypanosomes. A lethal effect was observed but limited to the infectious phase of the parasitic growth cycle. Since the inhibitors are known only to act on proteas...

journal_title：Biochemical and biophysical research communications

authors： Ashall F,Angliker H,Shaw E

更新日期：1990-07-31 00:00:00

abstract：:The amino acid sequence of the rat 40S ribosomal subunit protein S18 was deduced from the sequence of nucleotides in a recombinant cDNA. S18 has 152 amino acids and has a molecular weight of 17,707. Hybridization of the cDNA to digests of nuclear DNA suggests that there are 10-13 copies of the S18 gene. The mRNA for t...

journal_title：Biochemical and biophysical research communications

authors： Chan YL,Paz V,Wool IG

更新日期：1991-08-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) that lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is a breast cancer subtype with very aggressive metastasis and poor prognosis. Unique cartilage matrix-associated protein (UCMA) is a vitamin K-dependent...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Lee YJ,Park SI,Kim JE

更新日期：2020-10-01 00:00:00

abstract：:Fatty Acid Synthase (FASN), a 250-kDa cytosolic multi-enzyme catalyzing eukaryotic de novo FA biogenesis, unexpectedly localizes in cancer cell culture supernatants and in the blood of cancer patients. High levels of "extracellular FASN" have recently been found in supernatants from Hepatitis C Virus-infected liver ce...

journal_title：Biochemical and biophysical research communications

authors： Oliveras-Ferraros C,Vazquez-Martin A,Fernández-Real JM,Menendez JA

更新日期：2009-01-16 00:00:00

abstract：:Glucose depressed DNA synthesis in rat hepatocytes in primary culture. As compared to controls cultured with 5.6 mM glucose, maximal (> or = 75%) inhibition was obtained at 20-30 mM, and half-maximal effect at 10-15 mM. Comparison of D- and L-glucose showed that the effect was specific for the D-form. Maximal inhibiti...

journal_title：Biochemical and biophysical research communications

authors： Dajani OF,Refsnes M,Guren TK,Horn RS,Thoresen GH,Christoffersen T

更新日期：1994-08-15 00:00:00

abstract：:To investigate the role of secondary structure in the substrate specificity of human 72 kDa type IV collagenase, we synthesised linear and cyclic collagen sequence analogs. As Ca2+ plays a crucial role in the enzyme activity, the CD and FTIR spectra of the peptides were also measured in the presence of Ca2+. Most of t...

journal_title：Biochemical and biophysical research communications

authors： Likó Z,Botyánszki J,Bódi J,Vass E,Majer Z,Hollósi M,Süli-Vargha H

更新日期：1996-10-14 00:00:00

abstract：:Recent research revealed that doxorubicin (DOX) decreased expression of programmed death-ligand 1 (PD-L1) in cancer cells. However, the detailed mechanisms underlying this effect are not well established. Here, we demonstrate that doxorubicin down-regulates PD-L1 expression through induction of AU-rich element (ARE) b...

journal_title：Biochemical and biophysical research communications

authors： Kim DJ,Jang JH,Ham SY,Choi SH,Park SS,Jeong SY,Kim BC,Jeon DY,Lee BJ,Ko BK,Park JW,Cho WJ

更新日期：2020-02-05 00:00:00