Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP⁺-dependent isocitrate dehydrogenase.

abstract：:Burkitt's lymphoma is an aggressive B-cell neoplasm resulting from deregulated c-myc expression. We have previously shown that proliferation of Burkitt's lymphoma cell lines such as Ramos is markedly reduced by iron treatment. It has been shown that iron induces expression of c-myc which, owing to its transcriptional ...

journal_title：Biochemical and biophysical research communications

authors： Habel ME,Jung D

更新日期：2006-03-24 00:00:00

abstract：:The oxygen reaction of Nitrosomonas europaea cytochrome c oxidase containing either 2Cu or 1Cu per two heme a molecules was investigated by the flow-flash technique at 20 degrees C. The reaction profiles of the bacterial enzyme were essentially the same as those of bovine heart cytochrome c oxidase, although the rate ...

journal_title：Biochemical and biophysical research communications

authors： Orii Y,Sakamoto T,Fukumori Y,Yamanaka T

更新日期：1992-02-14 00:00:00

abstract：:Methylated lysyl and arginyl residues are present in the two major heat shock proteins, hsp70A and hsp70B, of chicken embryo fibroblasts. Here, we demonstrate that this methylation can be modulated by sodium arsenite, a chemical that increases the synthesis of hsp70. In particular, in hsp70A the amount of epsilon-N-tr...

journal_title：Biochemical and biophysical research communications

authors： Wang C,Lazarides E

更新日期：1984-03-15 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) brings about a wide spectrum of toxic and biochemical changes, most of which are mediated by the AH receptor (AHR). Recent cloning of the AHR from the two most TCDD-resistant laboratory animals, Han/Wistar (Kuopio) rats and hamsters, suggested a critical role for the C-termin...

journal_title：Biochemical and biophysical research communications

authors： Korkalainen M,Tuomisto J,Pohjanvirta R

更新日期：2001-08-03 00:00:00

abstract：:Reactive oxygen species (ROS) are an important factor in the development of skin lesions in diabetes. A new antioxidant, hydrogen, can selectively neutralize hydroxyl radicals (()OH) and peroxynitrite (ONOO(-)) in cell-free systems, whereas it seldom reacts with other ROS. Fibroblasts are a key component of skin. In t...

journal_title：Biochemical and biophysical research communications

authors： Yu P,Wang Z,Sun X,Chen X,Zeng S,Chen L,Li S

更新日期：2011-06-03 00:00:00

abstract：:17α-estradiol is a hormonally inactive isomer of 17β-estradiol, but with similar potency as neuroprotector. However, we have previously reported that pretreatment with high concentration (10 μM) of both estrogens abolishes their neuroprotection in rat cerebellar granule neurons. Here, we have examined neuroprotective ...

journal_title：Biochemical and biophysical research communications

authors： Sørvik IB,Paulsen RE

更新日期：2017-08-26 00:00:00

abstract：:c-Raf-1 is a serine/threonine-specific protein kinase which is regulated by phosphorylation. A putative c-AMP dependent protein kinase PKA phosphorylation site with the consensus sequence RRXS, Ser43, and a predominant phosphorylation site of c-Raf-1, Ser259, can be phosphorylated by PKA in vitro as shown by compariso...

journal_title：Biochemical and biophysical research communications

authors： Schramm K,Niehof M,Radziwill G,Rommel C,Moelling K

更新日期：1994-06-15 00:00:00

abstract：:The presence of highly specific serum binding proteins for growth hormone (GH) has been well characterized in many species. In the rat the major growth hormone-binding protein (GH-BP) is a truncated, variant form of the target tissue GH receptor and is derived by an alternative mRNA splicing event. The GHBP mRNA is co...

journal_title：Biochemical and biophysical research communications

authors： Tiong TS,Herington AC

更新日期：1991-10-31 00:00:00

abstract：:Heat shock proteins 60 (hsp60) and 10 (hsp10) are essential for the formation and restoration of many supramolecular structures. For reconstitution of these structures, we isolated stable hsps of 61kDa and 12kDa, which are similar to hsp60 and hsp10, respectively, from the supernatant fraction of thermophilic bacteriu...

journal_title：Biochemical and biophysical research communications

authors： Tamada H,Ohta T,Hamamoto T,Otawara-Hamamoto Y,Yanagi M,Hiraiwa H,Hirata H,Kagawa Y

更新日期：1991-08-30 00:00:00

abstract：:Using antibodies to the procollagen C-proteinase enhancer of mouse fibroblast culture medium, we have screened by immunoblotting extracts of several post natal mouse and rat tissues for the presence of the enhancer antigen. All rodent connective tissues were relatively rich in enhancer; lower amounts were found in ske...

journal_title：Biochemical and biophysical research communications

authors： Kessler E,Mould AP,Hulmes DJ

更新日期：1990-11-30 00:00:00

abstract：:This paper reports the identification of a Rho family nucleotide exchange factor termed mNET1 as a candidate-interacting partner for the first PDZ domain of MAGI-1, a membrane-associated guanylate kinase with inverted arrangement of protein-protein interacting modules. mNET1 was identified in a yeast two-hybrid screen...

journal_title：Biochemical and biophysical research communications

authors： Dobrosotskaya IY

更新日期：2001-05-18 00:00:00

abstract：:Stress activated c-Jun N-terminal Kinase-3 (JNK3) has been reported to act on mitochondrion to promote neuronal cell death. Phosphorylation of mitochondrial Voltage-Dependent Anion Channel (VDAC) plays an important role in mitochondria-mediated cell death. Keeping these in view phosphorylation of rat brain VDAC by JNK...

journal_title：Biochemical and biophysical research communications

authors： Gupta R,Ghosh S

更新日期：2015-03-27 00:00:00

abstract：:A cDNA for murine transcription factor S-II (Hirashima et al., J. Biol. Chem (1988) 263, 3858-3863) was inserted into a silkworm baculovirus vector and expressed in Bm-N cells, a cell line of Bombyx mori maintained in the laboratory. Recombinant S-II was purified from virus-infected cell extracts to near homogeneity b...

journal_title：Biochemical and biophysical research communications

authors： Hirashima S,Horikoshi N,Sekimizu K,Natori S

更新日期：1989-05-15 00:00:00

abstract：:We have determined the ability of two well-characterized eukaryotic homing endonucleases, I-PpoI from the myxomycete Physarum polycephalum and I-CreI from the green alga Chlamydomonas reinhardtii, to generate site-specific DNA double-strand breaks in human cells. These 18-kDa proteins cleave highly conserved 15- or 24...

journal_title：Biochemical and biophysical research communications

authors： Monnat RJ Jr,Hackmann AF,Cantrell MA

更新日期：1999-02-05 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.3.4.) activity and cell membrane fluidity measured by fluorescence polarization using 1,6 diphenyl, 1,3,5-hexatriene as fluorescent probe have been concomitantly examined in HTC hepatoma cells, both in relation to growth rate and in response to treatment with h...

journal_title：Biochemical and biophysical research communications

authors： Richert L,Castagna M,Beck JP,Rong S,Luu B,Ourisson G

更新日期：1984-04-16 00:00:00

abstract：:Planar bilayer studies are reported on the channel activity of des-L X Val7-D X Val8-Gramicidin A. This analog is designed to provide more long-lived side chain distributions involving the Trp residues than occur with Gramicidin A. The carbonyls of these residues coordinate the permeant cation and the energetics of th...

journal_title：Biochemical and biophysical research communications

authors： Urry DW,Alonso-Romanowski S,Venkatachalam CM,Harris RD,Prasad KU

更新日期：1984-02-14 00:00:00

abstract：:Isolated rat hepatocytes exposed to CCl4 showed a dramatic decrease in [32P] incorporation into proteins which was evident as early as 5 min after the haloalkane addition. DEAE cellulose separation of protein kinases present in both particulated and cytosolic fractions of hepatocytes revealed that only the calcium and...

journal_title：Biochemical and biophysical research communications

authors： Poli G,Albano E,Dianzani MU,Melloni E,Pontremoli S,Marinari UM,Pronzato MA,Cottalasso D

更新日期：1988-06-16 00:00:00

abstract：:Increasing antimicrobial drug resistance is a global threat especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as an important bottleneck that prevents a sufficient antibacterial effect to be achieved at low doses of the antibiotics. In particul...

journal_title：Biochemical and biophysical research communications

authors： Citak F,Ghai I,Rosenkötter F,Benier L,Winterhalter M,Wagner R

更新日期：2018-01-01 00:00:00

abstract：:Necrotic cells are known to develop characteristic membrane blebs. We measured protein concentration within necrotic blebs and found that it can be reduced by as much as twenty-fold compared to the main cell body (CB). These results raise two questions: 1. Why do proteins vacate the bleb? 2. How can osmotic equilibriu...

journal_title：Biochemical and biophysical research communications

authors： Rana PS,Mudrak NJ,Lopez R,Lynn M,Kershner L,Model MA

更新日期：2017-10-21 00:00:00

abstract：:A general strategy is described for using the cleavage site of restriction enzymes in vectors for cloning regardless of how many sites the given enzymes have in the vector. The application of this method allows one to open any vector at its cloning site with protruding ends which can be compatible with almost every co...

journal_title：Biochemical and biophysical research communications

authors： Welker E,Váradi A

更新日期：2000-05-10 00:00:00

abstract：:DmTTF is a Drosophila melanogaster mitochondrial DNA-binding protein which binds specifically to two homologous non-coding sequences located at the 3' ends of blocks of genes encoded on opposite strands. In order to test whether this protein acts as transcription termination factor, we assayed the capacity of DmTTF to...

journal_title：Biochemical and biophysical research communications

authors： Roberti M,Fernandez-Silva P,Polosa PL,Fernandez-Vizarra E,Bruni F,Deceglie S,Montoya J,Gadaleta MN,Cantatore P

更新日期：2005-05-27 00:00:00

abstract：:The effect of thyroid-stimulating hormone receptor (TSHR) on hepatic lipid accumulation in vivo is not fully understood. Further, while TSHR in the thyroid has been studied extensively, whether and how the absence of TSHR in the liver affects systemic energy metabolism has not yet been reported. To examine these effec...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Wu K,Zhang L,Gao L,Chen S

更新日期：2018-02-26 00:00:00

abstract：:The mitochondrial uncoupling protein UCP-1 uncouples respiration from ATP synthesis in brown adipose tissue (BAT) and thus energy is dissipated as heat. Recently two further isoforms have been identified which may play a similar role in other tissues. We have determined the effects of the rodent-selective beta3-adreno...

journal_title：Biochemical and biophysical research communications

authors： Emilsson V,Summers RJ,Hamilton S,Liu YL,Cawthorne MA

更新日期：1998-11-18 00:00:00

abstract：:C-terminal binding protein 2 (CtBP2) is a transcriptional co-repressor involved in cell migration, apoptosis, and tumorization. Up-regulation of CtBP2 is implicated in various human cancers including breast cancers. In our present study, we found that the C-terminus of Hsc70-interacting protein (CHIP) regulated the st...

journal_title：Biochemical and biophysical research communications

authors： Lee JS,Yoo SJ

更新日期：2013-03-15 00:00:00

abstract：:We have previously reported that intraplatelet "cyclic AMP jumps" produced with newly synthesized photoactivatable cyclic AMP analogue, inhibited washed rat platelet aggregation and serotonin release as induced by thrombin. Using the same approach on human platelets, thrombin-induced platelet aggregation was dose-depe...

journal_title：Biochemical and biophysical research communications

authors： Blache D,Ciavatti M,Ponsin G,Nargeot J

更新日期：1987-07-15 00:00:00

abstract：:Reactive oxygen species (ROS) contributes to endothelial dysfunction that is involved in the pathogeneses of hypertension. Vascular peroxidase 1 (VPO1) can utilize ROS to catalyze peroxidative reactions, possibly enhancing endothelial dysfunction. This study is to identify VPO1's involvement in endothelial dysfunction...

journal_title：Biochemical and biophysical research communications

authors： Yang L,Bai Y,Li N,Hu C,Peng J,Cheng G,Zhang G,Shi R

更新日期：2013-10-04 00:00:00

abstract：:In this study we describe exceptionally high protective effects of silymarin, a flavonoid antioxidant isolated from milk thistle, against 12-O-tetradecanoylphorbol 13-acetate (TPA)- and okadaic acid (OA)-caused tumor promotion in SENCAR mouse skin. Pre-application of silymarin to that of TPA in 7, 12-dimethylbenz(a)an...

journal_title：Biochemical and biophysical research communications

authors： Zi X,Mukhtar H,Agarwal R

更新日期：1997-10-09 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a vital role in vasculature response to hemodynamic stimuli via the degradation of extracellular matrix substrates. In this study, we investigated the putative role of cyclic strain-induced endothelial MMP-2 (and MMP-9) expression and release in modulating bovine aortic smooth mus...

journal_title：Biochemical and biophysical research communications

authors： von Offenberg Sweeney N,Cummins PM,Birney YA,Redmond EM,Cahill PA

更新日期：2004-07-23 00:00:00

abstract：:Chemical modifications on human hemoglobin were performed with the aim to change both surface and active-site hydrophobicities. The modifications included covalent coupling of poly(ethylene)glycol (5000 MW) on free amino groups and the methyl esterification of free carboxylic groups. The modified hemoglobin was assaye...

journal_title：Biochemical and biophysical research communications

authors： Torres E,Vazquez-Duhalt R

更新日期：2000-07-14 00:00:00

abstract：:Zebrafish have high regenerative ability in several organs including the fin. Although various mechanisms underlying fin regeneration have been revealed, some mechanisms remain to be elucidated. Recently, extracellular vesicles (EVs) have been the focus of research with regard to their role in cell-to-cell communicati...

journal_title：Biochemical and biophysical research communications

authors： Ohgo S,Sakamoto T,Nakajima W,Matsunaga S,Wada N

更新日期：2020-12-17 00:00:00