Dispersity of des-L X Val7-D X Val8-Gramicidin A single channel conductances argues for different side chain orientations as basis.

abstract：:To investigate the role of the carboxyl group in deltorphin molecules, we have synthesized three new analogues in which the acidic amino acid residues in position 4 of the deltorphins were replaced by non-acidic but hydrophilic amino acids residues. The three analogues, [Ser4]-, [Gln4]-, and [Cys4]-deltorphin, all are...

journal_title：Biochemical and biophysical research communications

authors： Misicka A,Lipkowski AW,Fang L,Knapp RJ,Davis P,Kramer T,Burks TF,Yamamura HI,Carr DB,Hruby VJ

更新日期：1991-11-14 00:00:00

abstract：:Identifying Mycobacterium tuberculosis membrane proteins involved in binding to and invasion of host cells is important in designing subunit-based anti-tuberculosis vaccines. The Rv2969c gene sequence was identified by PCR in M. tuberculosis complex strains, being transcribed in M. tuberculosis H37Rv, M. tuberculosis ...

journal_title：Biochemical and biophysical research communications

authors： Patarroyo MA,Plaza DF,Ocampo M,Curtidor H,Forero M,Rodriguez LE,Patarroyo ME

更新日期：2008-08-08 00:00:00

abstract：:In the presence of Mg-GTP, the rat liver guanylate cyclase, in either intact membranes or trypsin solubilized form, was stimulated by protoporphyrin IX 6 to 10-fold. However, when Mn-GTP was the substrate, protoporphyrin IX activated the membrane-bound guanylate cyclase only 50%, in contrast to the marked activation r...

journal_title：Biochemical and biophysical research communications

authors： Lacombe ML,Eberentz-Lhomme C

更新日期：1983-10-14 00:00:00

abstract：:Reversible phosphorylation of RNA polymerase (RNAP) II's largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism. The CTD phosphatase, FCP1, catalyzes the dephosphorylation of RNAP II and is thought to play a major role in polymerase recycling. In this study, we isolated a novel phosphatase gene ...

journal_title：Biochemical and biophysical research communications

authors： Zheng H,Ji C,Gu S,Shi B,Wang J,Xie Y,Mao Y

更新日期：2005-06-17 00:00:00

abstract：:Ectopic over-expression of nucleophosmin/B23 caused a marked up-regulation in the amounts of Yin Yang 1 (YY1) and proliferating cellular nuclear antigen (PCNA) proteins. Transfection with nucleophosmin/B23-targeting siRNA induced a decrease in the intracellular amounts of nucleophosmin/B23, YY1, and PCNA. PCNA express...

journal_title：Biochemical and biophysical research communications

authors： Weng JJ,Yung BY

更新日期：2005-09-30 00:00:00

abstract：:Smooth muscle of guinea-pig taenia caecum was desensitized by treatment with 10(-4)M carbachol or 10(-4)M histamine for 30 min in Ca-free solution containing 2mM EGTA. Phosphatidylinositol turnover stimulated by carbachol was not reduced by desensitization with either carbachol or histamine, while the turnover stimula...

journal_title：Biochemical and biophysical research communications

authors： Hishinuma S,Uchida MK

更新日期：1989-07-31 00:00:00

abstract：:p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes. In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, to...

journal_title：Biochemical and biophysical research communications

authors： Agostini M,Tucci P,Chen H,Knight RA,Bano D,Nicotera P,McKeon F,Melino G

更新日期：2010-12-03 00:00:00

abstract：:A fragment of polyoma virus DNA lacking the carboxy-terminal part of the large T antigen coding region is sufficient to express the functions of the entire gene in cell transformation. Two cell lines expressing this truncated DNA were studied, one of them producing a large T-related protein of the expected size (37 kD...

journal_title：Biochemical and biophysical research communications

authors： Guizani I,Clertant P,Cuzin F

更新日期：1987-04-29 00:00:00

abstract：:Dexamethasone (DEX), a potent glucocorticoid, increased the expression of T-cell death associated gene 8 (TDAG8), a proton-sensing G protein-coupled receptor, which is associated with the enhancement of acidic pH-induced cAMP accumulation, in peritoneal macrophages. We explored the role of increased TDAG8 expression i...

journal_title：Biochemical and biophysical research communications

authors： He XD,Tobo M,Mogi C,Nakakura T,Komachi M,Murata N,Takano M,Tomura H,Sato K,Okajima F

更新日期：2011-12-02 00:00:00

abstract：:Mouse monoclonal antibodies were generated against human ribonuclease inhibitor, an intracellular regulatory protein. A total of four antibodies were isolated, all of which were of the immunoglobulin G1 subtype. Western blot analysis of the antibodies suggested monospecificity. Based on immunoradiometric competition a...

journal_title：Biochemical and biophysical research communications

authors： Feldman M,Kohtz DS,Kleinberg DL

更新日期：1988-11-30 00:00:00

abstract：:A novel N-terminally substituted Pro(3) analogue of glucose-dependent insulinotropic polypeptide (GIP) was synthesized and tested for plasma stability and biological activity both in vitro and in vivo. Native GIP was rapidly degraded by human plasma with only 39 +/- 6% remaining intact after 8 h, whereas (Pro(3))GIP w...

journal_title：Biochemical and biophysical research communications

authors： Gault VA,O'Harte FP,Harriott P,Flatt PR

更新日期：2002-02-08 00:00:00

abstract：:Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate c...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Aino H,Ogawa N,Nagata S,Baba A

更新日期：1994-04-29 00:00:00

abstract：:Integrins alpha(M)beta(2) plays important role on leukocytes, such as adhesion, migration, phagocytosis, and apoptosis. It was hypothesized that homomeric associations of integrin subunits provide a driving force for integrins activation, and simultaneously inducing the formation of integrins clusters. However, experi...

journal_title：Biochemical and biophysical research communications

authors： Fu G,Wang C,Wang GY,Chen YZ,He C,Xu ZZ

更新日期：2006-12-29 00:00:00

abstract：:The classified sediment with ethanol from sera of nude mice and humans showed a disturbing effect on L1210 cells in vitro and a lifesaving effect on L1210 cell-bearing mice in vivo. This factor was purified more than 2300-fold to a specific activity of approximately 1 X 10(5) U/mg by ethanol classified precipitation, ...

journal_title：Biochemical and biophysical research communications

authors： Sakagami Y,Manabe H

更新日期：1984-04-30 00:00:00

abstract：:A nonreducible cyclic analog of somatostatin (SRIF) was prepared by a combination of solid phase and solution peptide synthesis. The compound, gamma-Abu-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Asp-OH, was tested for its effect on the release of growth hormone, glucagon and insulin in rats. It significantly suppressed ...

journal_title：Biochemical and biophysical research communications

authors： Garsky VM,Clark DE,Grant NH

更新日期：1976-12-20 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of nuclear receptors, is expressed at a high level in adipose tissue and plays an important role in adipocyte differentiation. In the present study, we identified the expression of PPARgamma in rat aortic smooth muscle cells (RASMC) using reverse t...

journal_title：Biochemical and biophysical research communications

authors： Iijima K,Yoshizumi M,Ako J,Eto M,Kim S,Hashimoto M,Sugimoto N,Liang YQ,Sudoh N,Toba K,Ouchi Y

更新日期：1998-06-18 00:00:00

abstract：:Dexamethasone (DEX), a glucocorticoid which induces cleft palate, causes marked alterations in the synthesis and degradation of phosphatidylinositol (PI) but not phosphatidylcholine in an established fibroblastic cell line derived from a human embryonic palate. Incorporation of radiolabeled inositol into phosphatidyli...

journal_title：Biochemical and biophysical research communications

authors： Grove RI,Willis WD,Pratt RM

更新日期：1983-01-14 00:00:00

abstract：:Prostate cancer has become one of commonest urologic tumors in male. In recent years, miRNAs are continually attracting attentions of researchers for their special regulatory function in human cancers. Previous study has revealed that miR-410 acts as a biomarker for the diagnosis of prostate cancer. Whereas, the speci...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zhang D,Lv J,Wang S,Zhang Q

更新日期：2018-09-18 00:00:00

abstract：:HSP60 has been proved to be closely related to atherosclerosis due to its antigenicity. To determine this antigenicity effect, the ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously (SC) for potential vaccine against atherosclerosis. Here, we observed the ApoE-/- mice wit...

journal_title：Biochemical and biophysical research communications

authors： Hu Y,Chen Z,Jiang L,Chen F,Jin R,Cheng L

更新日期：2018-04-15 00:00:00

abstract：:The ability of phospholipase C inhibitors to inhibit Ca2+ channel stimulation and Ca2+ release from intracellular stores evoked by norepinephrine in single rat portal vein myocytes was investigated in the aim of identifying the type of phospholipase C involved in the transduction pathways activated by alpha 1A- and al...

journal_title：Biochemical and biophysical research communications

authors： Macrez-Leprêtre N,Morel JL,Mironneau J

更新日期：1996-01-05 00:00:00

abstract：:A human isoform of the vesicle-associated membrane protein-associated proteins (VAPs), VAPB, causes amyotrophic lateral sclerosis eight due to the missense mutation of Pro-56, whereas human VAPA and the yeast VAP Scs2p proteins are not significantly affected by similar mutations. We have found that VAPA and Scs2p have...

journal_title：Biochemical and biophysical research communications

authors： Nakamichi S,Yamanaka K,Suzuki M,Watanabe T,Kagiwada S

更新日期：2011-01-14 00:00:00

abstract：:Sterol 14-demethylase P450 (P45014DM)-dependent formation of 4,4-dimethylcholesta-8,14,24-trienol, that has been reported for a mammalian meiosis-activating sterol, in rat ovaries was confirmed. Transient elevation of ovarian P45014DM activity, that might be related to the female sexual cycle of rat, was observed. The...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Yamashita C,Noshiro M,Fukuda M,Aoyama Y

更新日期：1996-06-25 00:00:00

abstract：:Two proteins (25- and 22-kDa) that cross-react with anti-gizzard SM22 alpha antibody were isolated from bovine aorta. The former, identical to a SM22 alpha homolog reported previously (Kobayashi, R., Kubota, T., and Hidaka, H. (1994) Biochem. Biophys. Res. Commun. 198, 1275-1280), associates with the membrane fraction...

journal_title：Biochemical and biophysical research communications

authors： Shishibori T,Yamashita K,Bandoh J,Oyama Y,Kobayashi R

更新日期：1996-12-04 00:00:00

abstract：:The Andean potato weevil, Premnotrypes vorax, an insect of the order Coleoptera, is a major cause of damage to potato crops in the Andean regions of South America. The insecticidal Cry proteins from Bacillus thuringiensis are useful biological pesticides, and some are toxic to Coleopteran insects. We overexpressed rec...

journal_title：Biochemical and biophysical research communications

authors： Gomez S,Mateus AC,Hernandez J,Zimmermann BH

更新日期：2000-12-20 00:00:00

abstract：:We report the initial results of our study into the use of a potential transition state (TS) of the reaction catalyzed by the enzyme estrone sulfatase (ES) in the design of a series of simple 4'-O-sulfamoyl-4-biphenyl-based compounds as novel inhibitors of ES. The results of the study show that these compounds are: po...

journal_title：Biochemical and biophysical research communications

authors： Ahmed S,James K,Owen CP

更新日期：2002-05-31 00:00:00

abstract：:A calcium-calmodulin (Ca2(+)-CaM) stimulated histone H3 phosphorylating activity was identified as a component of a nuclear protein complex purified from a 150 mM NaCl extract of calf thymus chromatin. This activity bound to a CaM-Sepharose affinity column in a Ca2+ dependent manner and was eluted off the column in th...

journal_title：Biochemical and biophysical research communications

authors： Wakim BT,Picken MM,DeLange RJ

更新日期：1990-08-31 00:00:00

abstract：:To investigate the role of inositol phospholipid turnover in the atrial natriuretic peptide (ANP) secretion, the secretory responses from isolated perfused rat hearts to the ionophore, A23187, and the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), alone or in combination, were studied. A23187 induced a sha...

journal_title：Biochemical and biophysical research communications

authors： Ruskoaho H,Toth M,Lang RE

更新日期：1985-12-17 00:00:00

abstract：:Cancer cells usually utilize glucose as a carbon source for aerobic glycolysis, a phenomenon known as the Warburg effect. Increasing studies have shown that PVT1 (a long non-coding RNA, lncRNA) functions as critical regulator of multiple cancers. However, it remains totally unknown whether and how PVT1 regulates gluco...

journal_title：Biochemical and biophysical research communications

authors： Song J,Wu X,Liu F,Li M,Sun Y,Wang Y,Wang C,Zhu K,Jia X,Wang B,Ma X

更新日期：2017-08-19 00:00:00

abstract：:In the brains of Alzheimer's disease patients, the tau protein abnormally aggregates to form an insoluble paired helical filament (PHF). Since the third repeat structure (R3) of the tau microtubule-binding domain plays an essential role in PHF formation and self-aggregates most significantly in an aqueous solution of ...

journal_title：Biochemical and biophysical research communications

authors： Minoura K,Mizushima F,Tokimasa M,Hiraoka S,Tomoo K,Sumida M,Taniguchi T,Ishida T

更新日期：2005-02-25 00:00:00

abstract：:Septic shock induced by lipopolysaccharide (LPS) is characterized by serious systemic inflammatory response and robust production of pro-inflammatory cytokines from activated macrophages. Damage-associated molecular patterns (DAMPs) secreted by activated macrophages are key contributors to septic shock. However, the c...

journal_title：Biochemical and biophysical research communications

authors： He Y,Peng Y,Tao L,Peng Z,Yang H

更新日期：2020-07-05 00:00:00