Phosphorylation of c-Raf-1 by protein kinase A interferes with activation.

abstract：:Human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) in vitro expansion for long term may undergo epigenetic and genetic alterations that subsequently induce cellular senescence and associated growth inhibition. Increasing evidence implicated that aberrant histone acetylation modulates gene expression res...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Zhong H,Wu M,Tan B,Zhao L,Yi Q,Xu X,Pan H,Bi Y,Yang K

更新日期：2019-07-12 00:00:00

abstract：:Branched-chain alpha-keto acid dehydrogenase (BCKDH) kinase (BDK) is responsible for the regulation of BCKDH complex, which is the rate-limiting enzyme in the catabolism of branched-chain amino acids (BCAAs). In the present study, we investigated the expression and activity of hepatic BDK in spontaneous type 2 diabete...

journal_title：Biochemical and biophysical research communications

authors： Doisaki M,Katano Y,Nakano I,Hirooka Y,Itoh A,Ishigami M,Hayashi K,Goto H,Fujita Y,Kadota Y,Kitaura Y,Bajotto G,Kazama S,Tamura T,Tamura N,Feng GG,Ishikawa N,Shimomura Y

更新日期：2010-03-05 00:00:00

abstract：:The Apical Junctional Complex (AJC) encompassing the tight junction (TJ) and adherens junction (AJ) plays a pivotal role in regulating epithelial barrier function and epithelial cell proliferative processes through signaling events that remain poorly characterized. A potential regulator of AJC protein expression is Gl...

journal_title：Biochemical and biophysical research communications

authors： Severson EA,Kwon M,Hilgarth RS,Parkos CA,Nusrat A

更新日期：2010-07-02 00:00:00

abstract：:Glucuronidated and/or methylated metabolites of the proanthocyanidin (PA) monomer (-)-epicatechin are detected in both blood and brain following feeding of rodents with a monomeric grape seed PA extract shown to reduce symptoms in a mouse model of Alzheimer's disease. To generate metabolites for future mechanistic stu...

journal_title：Biochemical and biophysical research communications

authors： Blount JW,Ferruzzi M,Raftery D,Pasinetti GM,Dixon RA

更新日期：2012-01-06 00:00:00

abstract：:The bacterial superantigen staphylococcal enterotoxin A (SEA) is a potent inducer of CTL activity and cytokine production in vivo. Protein A (PA) of Staphylococcal aureus has been found to have diverse biological response modifying properties and to possess antitumor, antitoxic and antiparasitic effects. In this study...

journal_title：Biochemical and biophysical research communications

authors： Mondal TK,Bhatta D,Biswas S,Pal P

更新日期：2002-02-01 00:00:00

abstract：:We have used RT-PCR with degenerate transmembrane primers to clone members of the G-coupled protein receptor family from rat hypothalamic suprachiasmatic nuclei. We report here a novel clone, UHR-1, which encodes a candidate receptor that is most similar to the neuropeptide receptor family, including the tachykinins, ...

journal_title：Biochemical and biophysical research communications

authors： Welch SK,O'Hara BF,Kilduff TS,Heller HC

更新日期：1995-04-17 00:00:00

abstract：:Fracture healing is a complicated regeneration process which to some extent recapitulates bone development. Fibroblast growth factor receptor 3 (FGFR3) has a negative regulatory effect on endochondral ossification, and FGFR3 is also expressed in prehypertrophic and hypertrophic chondrocytes during fracture healing. Ho...

journal_title：Biochemical and biophysical research communications

authors： Su N,Yang J,Xie Y,Du X,Lu X,Yin Z,Yin L,Qi H,Zhao L,Feng J,Chen L

更新日期：2008-11-21 00:00:00

abstract：:HSV-2 induces the transcription of c-fos gene in both human (diploid) cell strains and mouse (heteroploid) cell lines. HSV-1 is incapable of such induction. The induction of transcription is rapid and transient in both cell types. The product of transcriptional induction of c-fos in mouse cells is mainly a 4.5 kb fos ...

journal_title：Biochemical and biophysical research communications

authors： Goswami BB

更新日期：1987-03-30 00:00:00

abstract：:Hydrogenovibrio marinus strain MH-110, an obligately lithoautotrophic hydrogen-oxidizing bacterium, possesses three sets of the genes for ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO): namely, two form I type (cbbLS-1 and cbbLS-2) and one form II type (cbbM) enzymes. The cbbQ-m gene was located downstream ...

journal_title：Biochemical and biophysical research communications

authors： Hayashi NR,Arai H,Kodama T,Igarashi Y

更新日期：1999-11-01 00:00:00

abstract：:Evolutionary conserved SET domains were originally identified in three Drosophila proteins: suppressor of variegation (Su (var) 3-9), enhancer of zeste (E(z)), and the trithorax. Some of the SET-domain containing proteins have been known to elicit methylation of histone lysine residues. Based on a search for SET-domai...

journal_title：Biochemical and biophysical research communications

authors： Kim SM,Kee HJ,Eom GH,Choe NW,Kim JY,Kim YS,Kim SK,Kook H,Kook H,Seo SB

更新日期：2006-06-23 00:00:00

abstract：:The K-sam gene was first identified as an amplified gene in the poorly differentiated types, especially in the scirrhous type, of gastric cancers. We have recently found and reported that the carboxyl-terminal exons of K-sam are frequently deleted in the scirrhous type of gastric cancer. The deletion generates prefere...

journal_title：Biochemical and biophysical research communications

authors： Ueda T,Sasaki H,Aoyagi K,Narikiyo M,Tsubosa Y,Kuwahara Y,Sakamoto H,Mafune K,Yoshida T,Makuuchi M,Terada M

更新日期：1999-11-30 00:00:00

abstract：:Tissue-specific alternative RNA splicing in human F1gamma pre-mRNA produces muscle- and nonmuscle-type isoforms. Muscle-specific exclusion of exon 9 of the F1gamma gene is cell-specifically induced by acidic treatment of human fibrosarcoma HT1080 and rhabdomyosarcoma KYM-1 cells. We constructed an F1gamma minigene con...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Endo H,Hamamoto T,Kagawa Y

更新日期：1998-10-20 00:00:00

abstract：:The contribution of four transport pathways to Li+ influx in human, chicken and eel erythrocytes was studied. All pathways were measured simultaneously in each kind of blood sample to avoid possible temporal variations in transport parameters. We found that: 1) Li+ influx via Na(+)-K+ pump increased 2-3 fold in the or...

journal_title：Biochemical and biophysical research communications

authors： Romano L,Battaglia M,Cordì R,Rinaldi C,Leucci S,Amato A

更新日期：1995-05-05 00:00:00

abstract：:Cysteine proteases have been identified in parasitic protozoa including the causative agent of Chagas' disease Trypanosoma cruzi. T. cruzi lysates subjected to substrate-containing SDS-polyacrylamide gel electrophoresis exhibit major bands of proteolytic activity in the 45-55 kDa molecular mass range (cruzipain activi...

journal_title：Biochemical and biophysical research communications

authors： Wiser MF,Lonsdale-Eccles JD,D'Alessandro A,Grab DJ

更新日期：1997-11-26 00:00:00

abstract：:T cell immunotherapies are promising options in leukemia, among which the CD19/CD3-bispecific T cell engager antibody blinatumomab (MT103) has shown high response rates at very low doses in patients with lymphoma. However, the high CD47 expression in human lymphoma cells has limited the curative effects of blinatumoma...

journal_title：Biochemical and biophysical research communications

authors： Xu L,Wang S,Li J,Li B

更新日期：2019-02-12 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal pulmonary disorder, and its pathology is characterized by parenchymal fibrosis. To investigate the characteristics of fibroblasts in IPF, we obtained eight fibroblast cell lines from lungs with IPF and eight lines from normal lungs. We foun...

journal_title：Biochemical and biophysical research communications

authors： Shoda H,Yokoyama A,Nishino R,Nakashima T,Ishikawa N,Haruta Y,Hattori N,Naka T,Kohno N

更新日期：2007-02-23 00:00:00

abstract：:A new and simple method for the detection of antigenic proteins blotted onto nitrocellulose was developed. After transfer of spinach stromal proteins and purified phosphoribulokinase immunolabeling was performed with phosphoribulokinase antiserum, followed by a) Protein A-labeled colloidal gold particles, and b) by ho...

journal_title：Biochemical and biophysical research communications

authors： Surek B,Latzko E

更新日期：1984-05-31 00:00:00

abstract：:We found that rat bone marrow-derived macrophages responded to opsonized zymosan by releasing superoxide anion. However, these cells were defective in the response to the potent oxidative burst activator phorbol myristate acetate (PMA). This result was observed whatever the concentration of agonist used and with diffe...

journal_title：Biochemical and biophysical research communications

authors： Andre P,Capo C,Mege JL,Benoliel AM,Bongrand P

更新日期：1988-03-15 00:00:00

abstract：:The inward rectifier potassium channel, Kir2.1, contributes to the I(K1) current in cardiac myocytes and is closely associated with atrial fibrillation. Strong evidences have shown that atrial dilatation or stretch may result in atrial fibrillation. However, the role of Kir2.1 channels in the stretch-mediated atrial f...

journal_title：Biochemical and biophysical research communications

authors： He Y,Xiao J,Yang Y,Zhou Q,Zhang Z,Pan Q,Liu Y,Chen Y

更新日期：2006-12-15 00:00:00

abstract：:Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondro...

journal_title：Biochemical and biophysical research communications

authors： Bunning RA,Russell RG,Van Damme J

更新日期：1990-02-14 00:00:00

abstract：:Abnormal proliferation of vascular smooth muscle cells is a key event in the formation of atherosclerotic plaques in humans. It has been suggested that modulation of platelet derived growth factor chain A (PDGF-A) gene expression may contribute to atherosclerosis. Using an 'in situ hybridization' technique the present...

journal_title：Biochemical and biophysical research communications

authors： Zwijsen RM,Japenga SC,Heijen AM,van den Bos RC,Koeman JH

更新日期：1992-08-14 00:00:00

abstract：:The effects of n-3 polyunsaturated fatty acids (n-3PUFA) on obesity and diabetes were examined using KK-Ay mice fed with perilla oil (P), soybean oil (S), or lard (L), and those containing 30% fish oil (PF, SF, or LF), containing eicosapentaenoic acid (EPA = 9.9%) and docosahexaenoic acid (DHA = 18.0%). Perilla oil co...

journal_title：Biochemical and biophysical research communications

authors： Hun CS,Hasegawa K,Kawabata T,Kato M,Shimokawa T,Kagawa Y

更新日期：1999-05-27 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic, and accounts for more than 15% of strokes. Mutations in cardiac sodium channel alpha, beta1 and beta2 subunit genes (SCN5A, SCN1B, and SCN2B) have been identified in AF patients. We hypothesize that mutations in the sodium channel beta3 subu...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Yang Q,Wu X,Yang Y,Shi L,Wang C,Wu G,Xia Y,Yang B,Zhang R,Xu C,Cheng X,Li S,Zhao Y,Fu F,Liao Y,Fang F,Chen Q,Tu X,Wang QK

更新日期：2010-07-16 00:00:00

abstract：:We used fluorescence correlation spectroscopy (FCS) to study the activation of fibrinogen by thrombin and the subsequent aggregation of fibrin monomers into fibrin polymers at a very low and at physiological fibrinogen concentrations. In the labeling procedure used the fibrinogen was randomly labeled and the label was...

journal_title：Biochemical and biophysical research communications

authors： Bark N,Földes-Papp Z,Rigler R

更新日期：1999-06-24 00:00:00

abstract：:Examination of human follicular fluid revealed the presence of polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs) at concentrations of approximately 1 pg/ml (0.01 pg TEQ/ml). To study their possible action, two-cell mouse embryos were cultured in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumi O,Uechi H,Sone H,Yonemoto J,Takai Y,Momoeda M,Tohyama C,Hashimoto S,Morita M,Taketani Y

更新日期：1998-09-18 00:00:00

abstract：:Hypothalamic neurons monitor peripheral energy status and produce signals to adjust food intake and energy expenditure to maintain homeostasis. However, the molecular mechanisms by which these signals are generated remain unclear. Fluctuations in the level of hypothalamic malonyl-CoA are known to serve as an intermedi...

journal_title：Biochemical and biophysical research communications

authors： Dai Y,Wolfgang MJ,Cha SH,Lane MD

更新日期：2007-08-03 00:00:00

abstract：:Recombinant human OP-1 stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) significantly and in a dose-dependent manner in rat bone marrow cell culture. Newly formed MNCs either induced by hOP-1 alone or with 1,25(OH)2D3 were also positive for vitronectin recepto...

journal_title：Biochemical and biophysical research communications

authors： Hentunen TA,Lakkakorpi PT,Tuukkanen J,Lehenkari PP,Sampath TK,Väänänen HK

更新日期：1995-04-17 00:00:00

abstract：:The envelope glycoprotein E2 is the major immunodominant protein of the classical swine fever virus and can induce neutralizing antibodies and protective host-immune responses in infected swine. We designed, expressed, and purified multi-epitope protein (GST-BT22) that contains a tandem repeat of the E2 antigenic-dete...

journal_title：Biochemical and biophysical research communications

authors： Tian H,Hou X,Liu X

更新日期：2013-02-08 00:00:00

abstract：:The expression of mouse CYP27B1 in Escherichia coli has been dramatically enhanced by coexpression of GroEL/ES. To reveal the enzymatic properties of CYP27B1, we measured its hydroxylation activity toward vitamin D3 and 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) in addition to the physiological substrate 25(OH)D3. Surpri...

journal_title：Biochemical and biophysical research communications

authors： Uchida E,Kagawa N,Sakaki T,Urushino N,Sawada N,Kamakura M,Ohta M,Kato S,Inouye K

更新日期：2004-10-15 00:00:00

abstract：:[2-14C]-trans-2-hexadecenoyl CoA (16:1) and [2-14C]-trans-2-cis-8,11,14-eicosatetraenoyl CoA (20:4) were chemically synthesized and employed as competitive substrates for the liver microsomal trans-2-enoyl CoA reductase component of the fatty acid chain elongation system. Both 7.5 microM and 15 microM 20:4 competitive...

journal_title：Biochemical and biophysical research communications

authors： Nagi MN,Cook L,Prasad MR,Cinti DL

更新日期：1986-10-15 00:00:00