Acceleration of the oxygen reaction in CuA-deficient Nitrosomonas europaea cytochrome c oxidase as revealed by the flow-flash measurement.

abstract：:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes a small conductance cAMP-activated chloride ion channel. In the CF pancreatic duct, mutations in CFTR cause a reduction in bicarbonate secretion. This is thought to result from CFTR operating...

journal_title：Biochemical and biophysical research communications

authors： Hyde K,Harrison D,Hollingsworth MA,Harris A

更新日期：1999-09-24 00:00:00

abstract：:The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcr...

journal_title：Biochemical and biophysical research communications

authors： Rockel B,Schmaler T,Huang X,Dubiel W

更新日期：2014-07-25 00:00:00

abstract：:As in other vitamin D target cells, activation of voltage-dependent Ca2+ channels (VDCC) mediates the fast, non-genomic, 1,25(OH)2D3 stimulation of Ca2+ influx in skeletal muscle cells (SMC). 1,25(OH)2D3 has also been shown to rapidly induce the release of Ins(1,4,5)P3 in SMC. Experiments were performed to investigate...

journal_title：Biochemical and biophysical research communications

authors： Vazquez G,de Boland AR,Boland R

更新日期：1997-10-20 00:00:00

abstract：:The GABAA receptor (GABAAR) is the main inhibitory receptor in the adult mammalian brain. GABAAR function is dependent on its expression, distribution, and the chloride (Cl-) transmembrane gradient, which is determined by the potassium-chloride cotransporter 2 (KCC2) in the adult brain. KCC2 and GABAAR are downregulat...

journal_title：Biochemical and biophysical research communications

authors： Wan L,Chen L,Yu J,Wang G,Wu Z,Qian B,Liu X,Wang Y

更新日期：2020-11-12 00:00:00

abstract：:Epigenetics plays a role in the regulation of gene expression. Epigenetic changes control gene expression at the transcriptional level. Our previous study suggested that the La protein, which is mainly localized in the nucleus, was associated with hepatitis A virus (HAV) internal ribosomal entry site (IRES)-mediated t...

journal_title：Biochemical and biophysical research communications

authors： Kanda T,Sasaki R,Nakamoto S,Haga Y,Nakamura M,Shirasawa H,Okamoto H,Yokosuka O

更新日期：2015-10-23 00:00:00

abstract：:The VLDL (very low-density lipoprotein) receptor is a peripheral lipoprotein receptor expressing in fatty acid active tissues abundantly. In the Balb/c fasting mice, VLDL receptor as well as LPL (lipoprotein lipase), FAT (fatty acid translocase)/CD36, H-FABP (heart-type fatty acid-binding protein), ACS (acyl-CoA synth...

journal_title：Biochemical and biophysical research communications

authors： Kamataki A,Takahashi S,Masamura K,Iwasaki T,Hattori H,Naiki H,Yamada K,Suzuki J,Miyamori I,Sakai J,Fujino T,Yamamoto TT

更新日期：2002-05-10 00:00:00

abstract：:The development of rational methods to design 'continuous' sequence mimetics of discontinuous regions of protein sequence has, to now, been only marginally successful. This has been largely due to the difficulty of constraining the recognition elements of a mimetic structure to the relative conformational and spatial ...

journal_title：Biochemical and biophysical research communications

authors： Casset F,Roux F,Mouchet P,Bes C,Chardes T,Granier C,Mani JC,Pugnière M,Laune D,Pau B,Kaczorek M,Lahana R,Rees A

更新日期：2003-07-18 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) have played very important roles in the malignancy behaviors of hepatocellular carcinoma (HCC). Linc-cdh4-2 (TCONS_00027978) is a novel LncRNA that has been identified in HCC tissues from our previous study. Overexpression of linc-cdh4-2 in HCC cell lines (SK-Hep-1 and Huh7) significantl...

journal_title：Biochemical and biophysical research communications

authors： Gao Y,Wang G,Zhang C,Lin M,Liu X,Zeng Y,Liu J

更新日期：2016-11-18 00:00:00

abstract：:We have constructed a highly useful phage-displayed human antibody repertoire with limited cloning efforts. Our strategy was to maximize diversity during the first steps of library construction through the use of various lymphoid sources from several donors, inclusion of different immunoglobulin isotypes, and performa...

journal_title：Biochemical and biophysical research communications

authors： Rojas G,Lamdan H,Padron S,Munoz Y,Ayala M,Gavilondo JV

更新日期：2005-11-04 00:00:00

abstract：:Worldwide, hepatocellular carcinoma (HCC) remains a top instigator of cancer mortality. Previous clinical studies have revealed that low serum cholesterol predicts a poor outcome in HCC patients, but the potential role of cholesterol in the progression of HCC remains controversial. In the present study,we tested the i...

journal_title：Biochemical and biophysical research communications

authors： Zhao Z,Zhong L,He K,Qiu C,Li Z,Zhao L,Gong J

更新日期：2019-02-19 00:00:00

abstract：:The Mrr protein of Escherichia coli K12 is a cryptic Type IV restriction endonuclease whose activity appears to be triggered by high pressure stress. In this report we used high pressure to isolate and analyze several Mrr mutants, and generated a new structural model of the Mrr protein. The activity of a number of spo...

journal_title：Biochemical and biophysical research communications

authors： Orlowski J,Mebrhatu MT,Michiels CW,Bujnicki JM,Aertsen A

更新日期：2008-12-19 00:00:00

abstract：:The cellular actions of nerve growth factor (NGF) involve regulation of protein phosphorylation. In PC-12 pheochromocytoma cells, exposure of [125I]NGF followed by crosslinking indicates that the ligand binds to two discreet receptors, the previously described 75 kd protein, as well as the trk proto-oncogene product p...

journal_title：Biochemical and biophysical research communications

authors： Ohmichi M,Decker SJ,Pang L,Saltiel AR

更新日期：1991-08-30 00:00:00

abstract：:Cell membranes are vitally important to living cells. Although the infrastructure of biological membrane is provided by the lipid bilayer, membrane proteins perform most of the specific functions. Knowledge of membrane protein types often provides crucial hints toward determining the function of an uncharacterized mem...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Wang M,Chou KC

更新日期：2005-10-28 00:00:00

abstract：:We have cloned and sequenced rat testis cDNAs coding for a calcium binding polypeptide similar to calcineurin beta subunit, the Ca(2+)-binding subunit of the Ca2+/calmodulin stimulated protein phosphatase. Rat testis cDNA library was screened with a monoclonal antibody Va1 raised against bovine brain calcineurin beta ...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto M,Matsui H,Etoh S,Shimizu T,Nishio H,Moia LJ,Tokuda M,Itano T,Takenaka I,Hatase O

更新日期：1991-11-14 00:00:00

abstract：:Expression of ALP in F9 teratocarcinoma cells is induced by all-trans retinoic acid (ATRA) (Gianni' et al., Biochem. J. 274: 673-678, 1991). The specific ligand for retinoic acid related receptors (RXRs), 9-cis retinoic acid (9-cis RA), and three synthetic analogs binding to the alpha, beta and gamma forms of the reti...

journal_title：Biochemical and biophysical research communications

authors： Gianni M,Zanotta S,Terao M,Garattini S,Garattini E

更新日期：1993-10-15 00:00:00

abstract：:Treatment of human peripheral blood monocytes with oxidized (oxLDL), minimally modified low-density lipoprotein (mmLDL) or lysophosphatidylcholine (LPC) for 24h was associated with macrophage-like differentiation, as assessed by morphology/CD14 expression. Suppression of these effects by staurosporin (STS) indicated t...

journal_title：Biochemical and biophysical research communications

authors： Weber C,Erl W,Weber PC

更新日期：1995-01-17 00:00:00

abstract：:The bacterial toxin Shiga toxin (Stx) is transported retrogradely from early endosomes to the Golgi apparatus on its way to the endoplasmic reticulum (ER) and the cytosol. In this study we explored the functions of the two phosphoinositide binding proteins Sorting nexin 1 (SNX1) and Sorting nexin 2 (SNX2) in endosomal...

journal_title：Biochemical and biophysical research communications

authors： Utskarpen A,Slagsvold HH,Dyve AB,Skånland SS,Sandvig K

更新日期：2007-06-29 00:00:00

abstract：:Reactive oxygen species (ROS) play a crucial role in various physiological and pathological processes mediated by β-adrenergic receptors (β-ARs) in cardiomyocytes. However, the sources and signaling pathways involved in ROS production induced by acute β-AR activation have not yet been fully defined. In primary neonata...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Xiao H,Shen J,Wang N,Zhang Y

更新日期：2017-08-05 00:00:00

abstract：:The DNA segment harboring the promoter region and the exon 1 of the human tyrosinase gene has been cloned and characterized. Sequence analysis reveals the amino-terminal half of tyrosinase molecule including a signal peptide, of which six amino acid residues are not represented in the tyrosinase cDNA, pHT gamma 1 [Shi...

journal_title：Biochemical and biophysical research communications

authors： Takeda A,Tomita Y,Okinaga S,Tagami H,Shibahara S

更新日期：1989-08-15 00:00:00

abstract：:The eleven-nineteen lysine-rich leukemia protein (ELL) is a key regulator of RNA polymerase II mediated transcription. ELL facilitates RNA polymerase II transcription pause site entry and release by dynamically interacting with p300 and the positive transcription elongation factor b (P-TEFb). In this study, we investi...

journal_title：Biochemical and biophysical research communications

authors： Fufa TD,Byun JS,Wakano C,Fernandez AG,Pise-Masison CA,Gardner K

更新日期：2015-09-11 00:00:00

abstract：:A significant fraction of all proteins are misfolded and must be degraded. The ubiquitin-proteasome pathway provides an essential protein quality control function necessary for normal cellular homeostasis. Substrate specificity is mediated by proteins called ubiquitin ligases. In the endoplasmic reticulum (ER) a speci...

journal_title：Biochemical and biophysical research communications

authors： Mallinger A,Wen HM,Dankle GM,Glenn KA

更新日期：2012-02-03 00:00:00

abstract：:[3H] Nitrendipine binding was partially blocked by the presence of tetrodotoxin in developing spinal cord neurons. In young cultures, 1 micron tetrodotoxin displaced 29% and 26% of [3H] nitrendipine binding from the high and low affinity binding sites, respectively. In one month old cultures, tetrodotoxin had no effec...

journal_title：Biochemical and biophysical research communications

authors： Litzinger MJ,Brenneman DE

更新日期：1984-11-14 00:00:00

abstract：:Near-infrared (NIR) fluorescent dyes that are environmentally sensitive or solvatochromic are useful tools for protein labelling in in vivo biosensor applications such as glucose monitoring in diabetes since their spectral properties are mostly independent of tissue autofluorescence and light scattering, and they offe...

journal_title：Biochemical and biophysical research communications

authors： Khan F,Pickup JC

更新日期：2013-08-30 00:00:00

abstract：:Acute kidney injury induced by renal ischemia-reperfusion (IR) is a prominent risk factor in the development towards renal fibrosis. Ras-related C3 botulinum toxin substrate 1(Rac1) has been involved in the pathophysiology of fibrotic disorders. But the role of Rac1 in the pathogenesis of IR-induced renal fibrosis is ...

journal_title：Biochemical and biophysical research communications

authors： Liang H,Huang J,Huang Q,Xie YC,Liu HZ,Wang HB

更新日期：2018-09-18 00:00:00

abstract：:Thiol and disulfide compounds were tested as an anti-HIV drug against transactivator (Tat)-mediated transactivation of HIV-1. Of all the compounds tested, thiamine disulfide, alpha-lipoic acid, and N-acetycysteine significantly depressed HIV-1 Tat activity. Thiamine disulfide alone in these compounds possessing anti-H...

journal_title：Biochemical and biophysical research communications

authors： Shoji S,Furuishi K,Misumi S,Miyazaki T,Kino M,Yamataka K

更新日期：1994-11-30 00:00:00

abstract：:The distribution, labeling and interrelationship of microsomal and lysosomal dolichol and dolichyl-P in rat liver was investigated. After membrane induction with phenobarbital, N-nitrosodiethylamine and diethylhexylphthalate, the amount of microsomal and lysosomal dolichols are modulated independently. Liposomal label...

journal_title：Biochemical and biophysical research communications

authors： Edlund C,Chojnacki T,Dallner G

更新日期：1983-09-30 00:00:00

abstract：:The left-handed Z-DNA form of the short unmodified alternating guanine-cytosine oligonucleotides, 5'-(dGdC)(24) and 5'-(dGdC)(18), was selectively detected under physiological ionic strength and pH conditions using the anionic nickel(II) porphyrin, NiTPPS. No spectroscopic signal was observed for NiTPPS with any right...

journal_title：Biochemical and biophysical research communications

authors： D'Urso A,Choi JK,Shabbir-Hussain M,Ngwa FN,Lambousis MI,Purrello R,Balaz M

更新日期：2010-06-25 00:00:00

abstract：:A porphyrinic sensor was used to monitor nitric oxide release from vascular smooth muscle in response to exposure to ultraviolet light. Aortic rings exposed to UV light relaxed with a time course that parallels this observed NO release. With repeated UV light treatments, the magnitude of the relaxations diminished, su...

journal_title：Biochemical and biophysical research communications

authors： Kubaszewski E,Peters A,McClain S,Bohr D,Malinski T

更新日期：1994-04-15 00:00:00

abstract：:The effect of 1,25-(OH)2D3 on Concanavalin-A (ConA) mediated bovine lymphocyte proliferation was dependent on the magnitude of the proliferative response. Lymphocytes from cows with high inherent proliferative responses (134,904 +/- 15,488 cpm/well) were unaffected by 1,25-(OH)2D3; whereas, lymphocytes from cows with ...

journal_title：Biochemical and biophysical research communications

authors： Hustmyer FG,Nonnecke BJ,Beitz DC,Horst RL,Reinhardt TA

更新日期：1988-04-29 00:00:00

abstract：:The aim of this study was to understand the mechanism of action through which carnosine (beta-alanyl-L-histidine) acts as a quencher of cytotoxic alpha,beta-unsaturated aldehydes, using 4-hydroxy-trans-2,3-nonenal (HNE) as a model aldehyde. In phosphate buffer solution (pH 7.4), carnosine was 10 times more active as a...

journal_title：Biochemical and biophysical research communications

authors： Aldini G,Carini M,Beretta G,Bradamante S,Facino RM

更新日期：2002-11-15 00:00:00