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Separation of dolichol and dolichyl-P in microsomal and lysosomal compartments of hepatocytes.

Abstract：

:The distribution, labeling and interrelationship of microsomal and lysosomal dolichol and dolichyl-P in rat liver was investigated. After membrane induction with phenobarbital, N-nitrosodiethylamine and diethylhexylphthalate, the amount of microsomal and lysosomal dolichols are modulated independently. Liposomal labeled dolichol injected into the portal vein appears only in lysosomes and even after 8 days is still limited to the lysosomes. After in vivo labeling with [3H]mevalonate, high initial labeling of dolichol and dolichyl-P is present in microsomes and the labeling in microsomes is greater than that in lysosomes even after 8 h. The results demonstrate compartmentalization of the intracellular dolichols in hepatocytes. These lipids may have independent roles at different membrane locations.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Edlund C,Chojnacki T,Dallner G

doi

10.1016/s0006-291x(83)80022-9

subject

Has Abstract

pub_date

1983-09-30 00:00:00

pages

917-23

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)80022-9

journal_volume

115

pub_type

杂志文章

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