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Advanced glycation end products promote triple negative breast cancer cells via ERK and NF-κB pathway.

Abstract：

:Advanced glycation end products (AGEs) are harmful compounds generated by nonspecific glycation of proteins and lipids. The accumulation of AGEs is associated with various diseases, including breast cancer. AGEs have been shown to promote a breast cancer cell line by enhancing proliferation, invasion and migration. In this study, we investigated the effect and associated mechanism of AGEs on triple negative breast cancer cells. AGEs enhanced the proliferation, tumorigenicity, invasion and migration of primary breast cancer cells. AGEs also enhanced the RNA and protein expression of matrix metalloproteinase (MMP)-9 and its gelatinase activity. Enhanced MMP-9 expression was mediated by extracellular-signal regulated kinase (ERK) and nuclear factor kappa B (NF-κB) pathways. Moreover, inhibitors of ERK and NF-κB signaling attenuated the effect of AGEs on tumorigenicity, invasion and migration of primary breast cancer cells. Taken together, we suggest that AGEs directly promote primary breast cancer cells via the ERK and NF-κB pathway, which may lead to advanced therapeutic modalities of breast cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lee KJ,Yoo JW,Kim YK,Choi JH,Ha TY,Gil M

doi

10.1016/j.bbrc.2017.11.182

subject

Has Abstract

pub_date

2018-01-15 00:00:00

pages

2195-2201

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32360-4

journal_volume

495

pub_type

杂志文章

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