Picrotoxin is a CYP1A1 inducer in rainbow trout hepatocytes.

abstract：:The present study provides the first evidence for in vitro metabolic conversion of a 1,1-disubstituted hydrazine to the corresponding nitrosamine. The study shows that superoxide radical which is generated by NADPH-cytochrome c reductase is involved in the oxidation of 1,1-diphenylhydrazine to N-nitrosodiphenylamine c...

journal_title：Biochemical and biophysical research communications

authors： Tatsumi K,Kitamura S,Sumida M

更新日期：1984-02-14 00:00:00

abstract：:Free D-aspartic acid is present in appreciable quantities in the brain and other tissues of rodents and in human blood. In the newborn rat, the highest concentration of D-aspartic acid was found in cerebral hemispheres, where, at 164 nmol/g (8.4% of the total aspartic acid), the level of D-aspartic acid exceeds that o...

journal_title：Biochemical and biophysical research communications

authors： Dunlop DS,Neidle A,McHale D,Dunlop DM,Lajtha A

更新日期：1986-11-26 00:00:00

abstract：:Aminoglycosides are important antibiotics used against a wide range of pathogens. As a mechanism of defense, bacteria have evolved enzymes able to inactivate these drugs by regio-selectively adding a variety of functionalities (acetyl, phospho, and nucelotidyl groups) to their scaffolds. The aminoglycoside nucleotidyl...

journal_title：Biochemical and biophysical research communications

authors： Porter VR,Green KD,Zolova OE,Houghton JL,Garneau-Tsodikova S

更新日期：2010-12-03 00:00:00

abstract：:Focal adhesion kinase (FAK) and integrin-linked kinase (ILK) are both involved in integrin-mediated cell migration. However, the molecular mechanism, and the relationship between FAK and ILK activity in signaling transduction for the osteopontin (OPN)-induced migration of vascular smooth muscle cells (VSMCs) remain un...

journal_title：Biochemical and biophysical research communications

authors： Li JJ,Han M,Wen JK,Li AY

更新日期：2007-04-27 00:00:00

abstract：:Attachment of leukocytes to the vascular endothelium and the subsequent migration of cells into the vessel wall are early events in atherogenesis. This process requires the expression of endothelial adhesion molecules. Since tea catechins are reputed to promote antiatherogenic activities, we investigated the effects o...

journal_title：Biochemical and biophysical research communications

authors： Ludwig A,Lorenz M,Grimbo N,Steinle F,Meiners S,Bartsch C,Stangl K,Baumann G,Stangl V

更新日期：2004-04-09 00:00:00

abstract：:The ability of a myeloid leukemia cell line (HL-60) to undergo membrane electrical potential changes was followed during neutrophilic differentiation induced by 2 compounds. Membrane-potential changes were induced with 12-O-tetradecanoylphorbol 13-acetate (TPA) or formyl-methionyl-leucyl-phenylalanine (FMLP) and were ...

journal_title：Biochemical and biophysical research communications

authors： Brown GE,Fischkoff SA,Ordonez JV

更新日期：1984-09-28 00:00:00

abstract：:The effect of phosphorylation of calcineurin on calmodulin (CaM) binding was examined using a synthetic peptide which contains the CaM-binding domain and the serine phosphorylation site. The peptide, corresponding to residues 391-414 of brain calcineurin A subunit, was rapidly phosphorylated by protein kinase C and Ca...

journal_title：Biochemical and biophysical research communications

authors： Calalb MB,Kincaid RL,Soderling TR

更新日期：1990-10-30 00:00:00

abstract：:The Drosophila Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the Toll-1 receptor, only Spätzle (Spz) has been identified and characterized. We previously reported that Drosophila larva-derived tissue extract contains ligand activity for the To...

journal_title：Biochemical and biophysical research communications

authors： Nonaka S,Kawamura K,Hori A,Salim E,Fukushima K,Nakanishi Y,Kuraishi T

更新日期：2018-11-30 00:00:00

abstract：:We cloned and sequenced a full-length cDNA of human placental N-acetylgalactosamine-6-sulfate sulfatase, the enzyme deficient in Morquio disease. The 2339-nucleotide sequence contained 1566 nucleotides which encoded a polypeptide of 522 amino acid residues. The deduced amino acid sequence was composed of a 26-amino ac...

journal_title：Biochemical and biophysical research communications

authors： Tomatsu S,Fukuda S,Masue M,Sukegawa K,Fukao T,Yamagishi A,Hori T,Iwata H,Ogawa T,Nakashima Y

更新日期：1991-12-16 00:00:00

abstract：:Treatment of colorectal cancer (CRC) remains a challenge because of the lack of effective early treatment strategies and high incidence of relapse. 5-Fluorouracil (5-FU) is a typical CRC treatment. Bromosporine is an innovative bromodomain and extraterminal domain (BET) inhibitor. We investigated if CRC could be targe...

journal_title：Biochemical and biophysical research communications

authors： Cheng X,Huang Z,Long D,Jin W

更新日期：2020-01-22 00:00:00

abstract：:SHPS-1 is a receptor-type transmembrane glycoprotein, which contains four tyrosine residues in its cytoplasmic region, and the phosphorylation of these tyrosine residues serves the binding sites for SHP-2 protein-tyrosine phosphatase. Its extracellular region interacts with another membrane protein, CD47, thereby cons...

journal_title：Biochemical and biophysical research communications

authors： Sato R,Ohnishi H,Kobayashi H,Kiuchi D,Hayashi A,Kaneko Y,Honma N,Okazawa H,Hirata Y,Matozaki T

更新日期：2003-09-26 00:00:00

abstract：:Ascorbate and several phenolic compounds readily oxidise in cell culture media to generate hydrogen peroxide. However, addition of α-ketoglutarate, which is known to be released by several cell types, decreased the levels of H(2)O(2), and the α-ketoglutarate was depleted and converted to succinate. These observations ...

journal_title：Biochemical and biophysical research communications

authors： Long LH,Halliwell B

更新日期：2011-03-04 00:00:00

abstract：:When a plasmid encoding the Sleeping Beauty (SB) transposase (pCMV-SB) was cointroduced with luciferase expression plasmid DNA into mouse skeletal muscle at a molar ratio of 4:1, luciferase gene expression was 5 times higher than the expression without pCMV-SB on day 28. This enhancement was not dependent on the prese...

journal_title：Biochemical and biophysical research communications

authors： Masuda K,Yamamoto S,Endoh M,Kaneda Y

更新日期：2004-05-07 00:00:00

abstract：:An antifungal protein that inhibits the growth of filamentous fungal pathogens was isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) by affinity chromatography on Affi-gel blue gel and ion exchange chromatography on CM-Sepharose. The N-terminal amino acid sequence of the protein was highly homolog...

journal_title：Biochemical and biophysical research communications

authors： Lee JR,Park SC,Kim JY,Lee SS,Park Y,Cheong GW,Hahm KS,Lee SY

更新日期：2007-02-16 00:00:00

abstract：:The Bombyx mori nucleopolyhedrovirus (BmNPV) ie-1 promoter exhibits strong transcriptional activity and is used in transient foreign gene expression systems in insect cells. In a reporter assay experiment using the BmNPV ie-1 promoter, we found that it exhibited activity even in non-host mammalian BHK cells, plant BY-...

journal_title：Biochemical and biophysical research communications

authors： Fujita R,Ono C,Ono I,Asano SI,Bando H

更新日期：2015-09-04 00:00:00

abstract：:Blot-hybridization of sea urchin (Tripneustes gratilla) genomic DNA with a cloned rDNA probe revealed individual variation in the length of the rDNA repeat unit and also in the non-transcribed spacer sequences. The number of distinct rDNA repeat subclasses distinguishable within any one sea urchin was limited and usua...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Mandel M,Humphreys T

更新日期：1986-06-13 00:00:00

abstract：:Circadian rhythmic disorders induced by high-fat diet are associated with metabolic diseases. Resveratrol could improve metabolic disorder, but few reports focused on its effects on circadian rhythm disorders in a variety of studies. The aim of the present study was to analyze the potential effects of resveratrol on h...

journal_title：Biochemical and biophysical research communications

authors： Sun L,Wang Y,Song Y,Cheng XR,Xia S,Rahman MR,Shi Y,Le G

更新日期：2015-02-27 00:00:00

abstract：:We have recently isolated a rat homologue of the Caenorrhabditis elegans lin-10 product. Although rat lin-10 is expressed in the cytosol and membrane fractions of various tissues, it is distributed only in the membrane fraction in brain where it is enriched in the synaptic plasma membrane and postsynaptic density frac...

journal_title：Biochemical and biophysical research communications

authors： Ide N,Hata Y,Hirao K,Irie M,Deguchi M,Yao I,Satoh A,Wada M,Takahashi K,Nakanishi H,Takai Y

更新日期：1998-03-06 00:00:00

abstract：:Some properties of calmodulin(CaM)-binding proteins (CaMBPs) of the Ca(2+)-independent type were investigated in the synaptosomal membrane (SM) from rat brain using the [125I]CaM gel overlay method. When SM was prepared in the presence of Ca2+, Ca(2+)-independent CaM binding was decreased, whereas the Ca(2+)-dependent...

journal_title：Biochemical and biophysical research communications

authors： Natsukari N,Miwa A,Fujita M

更新日期：1992-03-16 00:00:00

abstract：:A synthetic geranylgeranoic acid (GGA) induced apoptotic cell death in a human hepatoma cell line, HuH-7, but not in mouse primary cultured hepatocytes. Prior to chromatin condensation, GGA induced a dramatic loss of the mitochondrial membrane potential in 1 hour and in a dose dependent manner in HuH-7 cells, but not ...

journal_title：Biochemical and biophysical research communications

authors： Shidoji Y,Nakamura N,Moriwaki H,Muto Y

更新日期：1997-01-03 00:00:00

abstract：:MicroRNAs are involved in cancer-related processes. The microRNA-21(miR-21) has been identified as the only miRNA over-expressed in a wide variety of cancers, including cervical cancer. However, the function of miR-21 is unknown in cervical carcinomas. In this study, we found that the inhibition of miR-21 in HeLa cerv...

journal_title：Biochemical and biophysical research communications

authors： Yao Q,Xu H,Zhang QQ,Zhou H,Qu LH

更新日期：2009-10-23 00:00:00

abstract：:On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supple...

journal_title：Biochemical and biophysical research communications

authors： Koch OR,De Leo ME,Borrello S,Palombini G,Galeotti T

更新日期：1994-06-30 00:00:00

abstract：:The inhibitory effect of sodium selenite on biliary secretion of methyl mercury was examined in rats. The biliary secretion of methyl mercury in rat treated with 1 mumol/kg of methyl mercury was significantly decreased by administration of selenite at doses of 0.05 mumol/kg or higher. In rats given 10 mumol/kg of meth...

journal_title：Biochemical and biophysical research communications

authors： Urano T,Imura N,Naganuma A

更新日期：1997-10-29 00:00:00

abstract：:The gonadotropin secretory response of anterior pituitary cells to phorbol esters includes both extracellular Ca2(+)-dependent and -independent components (Stojilković et al, 1988; J. Biol. Chem. 263, 17301-17306, 1988). In cultured pituitary cells, measurements of [Ca2+]i using Fura-2 and of LH release during cell pe...

journal_title：Biochemical and biophysical research communications

authors： Izumi S,Stojilković SS,Iida T,Krsmanović LZ,Omeljaniuk RJ,Catt KJ

更新日期：1990-07-16 00:00:00

abstract：:The genetic regulation necessary for the formation of a four-chambered heart is tightly regulated by transcription factors such as TBX20, a member of the T-box (TBX) transcription factor family. TBX20 is critical for proper cardiogenesis and is expressed in the heart throughout development. Missense mutations in TBX20...

journal_title：Biochemical and biophysical research communications

authors： Debenedittis P,Harmelink C,Chen Y,Wang Q,Jiao K

更新日期：2011-06-03 00:00:00

abstract：:Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (f...

journal_title：Biochemical and biophysical research communications

authors： Casabiell X,Piñeiro V,De la Cruz LF,Gualillo O,Folgar L,Diéguez C,Casanueva FF

更新日期：2000-09-24 00:00:00

abstract：:Ultrasound (US) has emerged as a promising noninvasive modality for neuromodulation. Despite previous evidence that US may mediate cellular response by activating mechanosensitive ion channels embedded in the cell membrane, the underlying mechanism is not well understood. In this work, we developed a vertically deploy...

journal_title：Biochemical and biophysical research communications

authors： Liao D,Li F,Lu D,Zhong P

更新日期：2019-10-20 00:00:00

abstract：:The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selective anti-herpes-virus compound. In order to synthesize and study the properties of a DNA that contains C-BVDU, the 5'-triphosphate, C-BVDUTP was prepared and evaluated as a potential substrate of the E. coli Klenow DNA...

journal_title：Biochemical and biophysical research communications

authors： Sági J,De Clercq E,Szemzö A,Csárnyi A,Kovács T,Otvös L

更新日期：1987-09-30 00:00:00

abstract：:Beta-catenin has essential roles in morphogenesis and human cancer, both as a subunit of adhesive complexes in the cell membrane and as a transcriptional coactivator in the Wnt signaling pathway. In addition, beta-catenin also has the ability to transport lymphoid enhancer binding factor-1 into the nucleus. In this st...

journal_title：Biochemical and biophysical research communications

authors： Hsu HT,Liu PC,Ku SY,Jung KC,Hong YR,Kao C,Wang C

更新日期：2006-05-12 00:00:00

abstract：:Accepted as crucial participators in human malignancies, long noncoding RNAs (lncRNAs) have been proven to exert significant function on the complicated processes of cancer progression. Although existing investigations have revealed the oncogenic role of lncRNA SOX2 overlapping transcript (SOX2-OT) in different kinds ...

journal_title：Biochemical and biophysical research communications

authors： Wo Q,Zhang D,Hu L,Lyu J,Xiang F,Zheng W,Shou J,Qi X

更新日期：2019-12-10 00:00:00