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Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor.

Abstract：

:The Drosophila Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the Toll-1 receptor, only Spätzle (Spz) has been identified and characterized. We previously reported that Drosophila larva-derived tissue extract contains ligand activity for the Toll-1 receptor, which differs from Spz based on the observation that larval extract prepared from spz mutants possessed full ligand activity. Here, we demonstrate that Spz5, a member of the Spz family of proteins, functions as a ligand for the Toll-1 receptor. Processing of Spz5 by Furin protease, which is known to be important for ligand activity of Spz5 to Toll-6, is not required for its function to the Toll-1 receptor. By generating a spz5 null mutant, we further showed that the Toll-1 ligand activity of larva-derived extract is mainly derived from Spz5. Finally, we found a genetic interaction between spz and spz5 in terms of developmental processes. This study identified a novel ligand for the Drosophila Toll-1 receptor, providing evidence that Toll-1 is a multi-ligand receptor, similar to the mammalian Toll-like receptor.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nonaka S,Kawamura K,Hori A,Salim E,Fukushima K,Nakanishi Y,Kuraishi T

doi

10.1016/j.bbrc.2018.10.096

subject

Has Abstract

pub_date

2018-11-30 00:00:00

pages

510-515

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)32252-6

journal_volume

506

pub_type

杂志文章

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