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Detection of antibody to hepatitis C E2/NS1 protein in patients with type C hepatitis.

Abstract：

:Putative E2/NS1 sequence of hepatitis C virus was expressed in E. coli as a fusion protein with maltose binding protein. Approximately 80 kDa protein was obtained containing 38 kDa E2/NS1 protein. The antibody to this protein was detectable in the same serum from which the sequence was amplified. It was also detectable in none of 7 acute hepatitis, in 2 of 12 chronic persistent hepatitis, in 3 of 25 chronic active hepatitis, and in 2 of 4 cirrhosis. It was detectable in none of 10 normal subjects. In 3 cases who were positive for the antibody before the interferon treatment, it became undetectable after the treatment. Thus, it seems that the antibody is not a neutralizing antibody and is related to active viral replication.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yokosuka O,Ito Y,Imazeki F,Ohto M,Omata M

doi

10.1016/0006-291x(92)91595-h

subject

Has Abstract

pub_date

1992-11-30 00:00:00

pages

565-71

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)91595-H

journal_volume

189

pub_type

杂志文章

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