Human bronchial epithelial cells express and secrete MMP-12.

abstract：:Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and diseas...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Iwai A,Nakayama Y,Morimoto J,Takada A,Maruyama M,Kida H,Uede T,Miyazaki T

更新日期：2012-01-06 00:00:00

abstract：:TAp63 belongs to the p53-tumour suppressor family and is capable of transactivating a set of target genes to induce cell cycle arrest and apoptosis. We showed that treatment of cancer cells with chemo-therapeutic drugs or the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA) results in induction of TAp63 expre...

journal_title：Biochemical and biophysical research communications

authors： Sayan BS,Yang AL,Conforti F,Bernardini S,Tucci P,Vasa-Nicotera M,Knight RA,Melino G

更新日期：2010-01-22 00:00:00

abstract：:The number of electrons involved in the more positive of the two redox couples of the iron-molybdenum cofactor of Azotobacter vinelandii nitrogenase has been investigated by controlled potential coulometry in both the oxidizing and reducing directions. A n value of 1 was determined for interconversion of the oxidized ...

journal_title：Biochemical and biophysical research communications

authors： Schultz FA,Gheller SF,Newton WE

更新日期：1988-04-29 00:00:00

abstract：:MicroRNA let-7i is up-regulated in T cells from patients with Ankylosing Spondylitis (AS). In this study, we investigated the role of let-7i in T cells survival. Our results demonstrated down-regulation of insulin-like growth factor-1 receptor (IGF1R) in T cells from patients with AS. Luciferase reporter assay suggest...

journal_title：Biochemical and biophysical research communications

authors： Hou C,Zhu M,Sun M,Lin Y

更新日期：2014-10-31 00:00:00

abstract：:The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Recombinant human EPO (rhEPO) is therefore used to treat anemia in cancer patients. However, clinical trials have indicated that rhEPO treatment might promote tumor progression and has a negative effect on patient s...

journal_title：Biochemical and biophysical research communications

authors： Reinbothe S,Larsson AM,Vaapil M,Wigerup C,Sun J,Jögi A,Neumann D,Rönnstrand L,Påhlman S

更新日期：2014-02-28 00:00:00

abstract：:Human prothrombin kringle-2 and its partial peptide, NSA9 (NSAVQLVEN), have been reported to have potent anti-angiogenic activities. Here, the internalization mechanism of NSA9 into bovine capillary endothelial (BCE) cells was examined using lactate dehydrogenase (LDH) release assay, fluorescence microscopy, and flow ...

journal_title：Biochemical and biophysical research communications

authors： Hwang HS,Kim SS

更新日期：2005-09-23 00:00:00

abstract：:miRNAs are recently found playing important roles in osteogenesis. In this study, we identified that miR-222-3p decreased during osteogenic differentiation of human mesenchymal stem cells (hBMSCs) using Quantitative Real-Time Reverse Transcription PCR (qRT-PCR). Furthermore, we investigated the effect of miR-222-3p on...

journal_title：Biochemical and biophysical research communications

authors： Yan J,Guo D,Yang S,Sun H,Wu B,Zhou D

更新日期：2016-02-12 00:00:00

abstract：:We investigated the effect of in vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both alpha and beta s...

journal_title：Biochemical and biophysical research communications

authors： DeCherney GS,Gesundheit N,Gyves PW,Showalter CR,Weintraub BD

更新日期：1989-03-15 00:00:00

abstract：:Membrane protein solubilized by octyl-beta-D-glucopyranoside in the presence of dispersed phospholipid was incubated with bath-sonicated liposomes and additional detergent. The proteoliposomes formed on dilution showed transport and exchange properties consistent with a reconstitution of phosphate:sugar 6-phosphate an...

journal_title：Biochemical and biophysical research communications

authors： Ambudkar SV,Maloney PC

更新日期：1985-06-14 00:00:00

abstract：:Angiogenesis is critical to a wide range of physiological and pathological processes. Scutellarin, a major flavonoid of a Chinese herbal medicine Erigeron breviscapus (Vant.) Hand. Mazz. has been shown to offer beneficial effects on cardiovascular and cerebrovascular functions. However, scutellarin's effects on angiog...

journal_title：Biochemical and biophysical research communications

authors： Gao ZX,Huang DY,Li HX,Zhang LN,Lv YH,Cui HD,Zheng JH

更新日期：2010-09-10 00:00:00

abstract：:DNA polymerases alpha and beta, Terminal deoxynucleotidyl Transferase and DNA ligases from chicken thymus were purified to homogeneity. Quinolone antibiotics (nalidixic acid, oxolinic acid and pefloxacin ) known to inhibit DNA replication were tested for their effects on these enzymes. DNA ligase activity was not affe...

journal_title：Biochemical and biophysical research communications

authors： Rusquet R,Bonhommet M,David JC

更新日期：1984-06-29 00:00:00

abstract：:RNA-binding proteins are believed to play important roles in regulation of neural functions. Recently, a mouse cDNA encoding the cold-inducible RNA-binding protein, Cirp, has been isolated, the amino acid sequence of which showed similarity to plant circadian rhythm proteins. In the present study, diurnal expression o...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama H,Xue JH,Sato T,Fukuyama H,Mizuno N,Houtani T,Sugimoto T,Fujita J

更新日期：1998-04-17 00:00:00

abstract：:One of the mechanisms underlying the induction of human inducible nitric oxide synthase (hiNOS) by cytokines is transcriptional regulation. However, previous reports suggest that in human cells, the cytokine activation of the hiNOS expression is accompanied by a drastic increase in cellular mRNA and protein content, b...

journal_title：Biochemical and biophysical research communications

authors： Nunokawa Y,Oikawa S,Tanaka S

更新日期：1997-04-17 00:00:00

abstract：:Vasoactive intestinal contractor (VIC) is a member of the endothelin (ET) family. We have investigated the regional distribution of VIC/ET-2 and of ET-1 gene expression in the adult murine brain and pituitary gland. We used real-time quantitative reverse transcription-linked polymerase chain reaction. VIC/ET-2 gene ex...

journal_title：Biochemical and biophysical research communications

authors： Masuo Y,Ishikawa Y,Kozakai T,Uchide T,Komatsu Y,Saida K

更新日期：2003-01-17 00:00:00

abstract：:Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity si...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Fukuda S,Tai HH

更新日期：1983-09-15 00:00:00

abstract：:TRIM62, also named DEAR1, is a member of the TRIM/RBCC family, which includes proteins with conserved RING finger, B-box and coiled-coil domains. Several reports have identified a role for this family in cancer, retroviral infection and innate immunity. In this study, the E3 ubiquitin ligase activity and subcellular l...

journal_title：Biochemical and biophysical research communications

authors： Huang F,Xiao H,Sun BL,Yang RG

更新日期：2013-03-08 00:00:00

abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Shi C,Wu J,Fu M,Zhang B,Wang J,Yang X,Chi Y

更新日期：2014-05-10 00:00:00

abstract：:Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix basement protein which was originally identified as a target antigen involved in anti-tubular basement membrane (TBM) antibody-mediated interstitial nephritis (TIN). Further investigations elucidated that TIN-ag plays a role in renal tubulogenesi...

journal_title：Biochemical and biophysical research communications

authors： Ikeda M,Takemura T,Hino S,Yoshioka K

更新日期：2000-02-05 00:00:00

abstract：:We have analyzed the cellular effects of nanosecond pulsed electrical fields on plant cells using fluorescently tagged marker lines in the tobacco cell line BY-2 and confocal laser scanning microscopy. We observe a disintegration of the cytoskeleton in the cell cortex, followed by contraction of actin filaments toward...

journal_title：Biochemical and biophysical research communications

authors： Berghöfer T,Eing C,Flickinger B,Hohenberger P,Wegner LH,Frey W,Nick P

更新日期：2009-09-25 00:00:00

abstract：:The major active protein phosphatase present in a rabbit skeletal muscle extract is associated with the glycogen particle and migrates in sucrose density gradient centrifugation as a Mr = 70,000 protein and contains modulator activity. Addition of extra modulator protein causes a time- and concentration-dependent conv...

journal_title：Biochemical and biophysical research communications

authors： Vandenheede JR,Yang SD,Merlevede W

更新日期：1983-09-30 00:00:00

abstract：:The calcium-sensing receptor (CaR) is a G protein-coupled receptor that plays key roles in extracellular calcium ion (Ca(2+)(o)) homeostasis by enabling parathyroid, kidney, and other cells to directly "sense" changes in Ca(2+)(o). In multiple myeloma-associated bone disease, myeloma cells could raise the level of Ca(...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Yamauchi M,Sugimoto T,Chauhan D,Anderson KC,Brown EM,Chihara K

更新日期：2002-12-13 00:00:00

abstract：:In malate dehydrogenase from Thermus flavus, substitution of Ile for Thr189, which is involved in hydrogen-bond network around a loop containing catalytic His186, caused an increase in the turnover number at room temperatures. In order to examine the effect of disruption of the hydrogen bonds on the catalytic activity...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama M,Kinoshita M,Kudo H,Horinouchi S,Tanokura M

更新日期：1996-08-23 00:00:00

abstract：:Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway, and the increa...

journal_title：Biochemical and biophysical research communications

authors： Hu D,Li D,Shigeta M,Ochi Y,Okauchi T,Neyama H,Kabayama S,Watanabe Y,Cui Y

更新日期：2021-01-08 00:00:00

abstract：:Lipoprotein (a) [Lp(a)], a risk factor for coronary artery disease, is a LDL-like particle with apolipoprotein (a) [apo(a)] covalently linked to apolipoprotein B (apoB). Apo(a) has many repeats of kringle 4-like domain, classified as type 1 through type 10 (T1-T10). Deletion analysis was performed to define the functi...

journal_title：Biochemical and biophysical research communications

authors： Trieu VN,McConathy WJ

更新日期：1998-10-09 00:00:00

abstract：:The effect of various differentiation-inducers on the activity of Ca2+, phospholipid-dependent protein kinase (C-kinase) activity and endogenous protein phosphorylation by the kinase were examined in the extracts of HL-60 cells. Although all of the inducers, retinoic acid, dibutyryl cAMP, nicotinamide, dimethylsulfoxi...

journal_title：Biochemical and biophysical research communications

authors： Tanaka Y,Tsuyuki M,Itaya-Hironaka A,Inada Y,Yoshihara K,Kamiya T

更新日期：1990-05-16 00:00:00

abstract：:Numerous synthetic chemicals have estrogenic activity by interacting with the estrogen receptor. In this report, we test the hypothesis that some estrogenic chemicals may also modulate the human progesterone receptor (hPR) signaling pathway. This was evaluated by examining synthetic chemicals for their ability to modu...

journal_title：Biochemical and biophysical research communications

authors： Tran DQ,Klotz DM,Ladlie BL,Ide CF,McLachlan JA,Arnold SF

更新日期：1996-12-13 00:00:00

abstract：:Extracellular acidic pH-activated chloride channel I(Cl, acid), has been characterized in HEK 293 cells and mammalian cardiac myocytes. This study was designed to characterize I(Cl,acid) in human umbilical vein endothelial cells(HUVECs). The activation and deactivation of the current rapidly and repeatedly follows the...

journal_title：Biochemical and biophysical research communications

authors： Ma ZY,Zhang W,Chen L,Wang R,Kan XH,Sun GZ,Liu CX,Li L,Zhang Y

更新日期：2008-07-04 00:00:00

abstract：:Incubation of cell sonicates from monoclonal B cells with arachidonic acid led to the formation of leukotriene (LT) B4 and 5-hydroxy-eicosatetraenoic acid (5-HETE). In contrast, stimulation of intact B cells with the calcium ionophore A23187 +/- arachidonic acid did not, under similar conditions, lead to formation of ...

journal_title：Biochemical and biophysical research communications

authors： Jakobsson PJ,Odlander B,Steinhilber D,Rosén A,Claesson HE

更新日期：1991-07-15 00:00:00

abstract：:Monoclonal antibodies are essential to the success of molecularly targeted therapies. Recently, numerous therapeutic antibodies have been developed for various diseases, including cancer and autoimmune diseases. Experimental systems to effectively evaluate these candidate antibodies are urgently needed. One of the mec...

journal_title：Biochemical and biophysical research communications

authors： Shiokawa M,Takahashi T,Murakami A,Kita S,Ito M,Sugamura K,Ishii N

更新日期：2010-09-03 00:00:00

abstract：:Adriamycin was used in situ, in isolated liver mitochondria of hyperthyroid rats to study the role of cardiolipin in the functioning of FAD-linked L-glycerol-3-phosphate dehydrogenase. The apparent kinetic parameters of the reaction catalyzed by the enzyme were affected by adriamycin. The effect of adriamycin was depe...

journal_title：Biochemical and biophysical research communications

authors： Beleznai Z,Jancsik V

更新日期：1989-02-28 00:00:00