Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism.

abstract：:Mutations in the Treacher Collins syndrome gene, TCOF1, cause a disorder of craniofacial development. We manipulated the levels of Tcof1 and its protein treacle in a murine neuroblastoma cell line to identify downstream changes in gene expression using a microarray platform. We identified a set of genes that have simi...

journal_title：Biochemical and biophysical research communications

authors： Mogass M,York TP,Li L,Rujirabanjerd S,Shiang R

更新日期：2004-12-03 00:00:00

abstract：:Because brain inositides are enriched in the 1-stearoyl-2-arachidonoyl species, they form a likely source for the tetraenoic free fatty acids (FFA) and diacylglycerols (DG) that are accumulated during seizures. To study inositide turnover during bicuculline-induced seizures, rats were injected intraventricularly and b...

journal_title：Biochemical and biophysical research communications

authors： Van Rooijen LA,Vadnal R,Dobard P,Bazan NG

更新日期：1986-04-29 00:00:00

abstract：:Vascular calcification increases the risk of developing cardiovascular disease, and it is closely associated with metabolic disorders such as diabetes mellitus and non-alcoholic fatty liver disease. We investigated whether the activators of AMP-activated protein kinase (AMPK), metformin, resveratrol, and exendin-4, im...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Hong SW,Kim MJ,Kwon H,Park SE,Rhee EJ,Lee WY

更新日期：2020-09-17 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a condition whereby the normal muscular function of the myocardium is altered by specific or multiple aetiologies. About 25-35% of DCM patients show familial forms of the disease, with most mutations affecting genes encoding cytoskeletal proteins. Most of the DCM-related mutations fall ...

journal_title：Biochemical and biophysical research communications

authors： Bollati M,Barbiroli A,Favalli V,Arbustini E,Charron P,Bolognesi M

更新日期：2012-02-10 00:00:00

abstract：:The apoform of neurocuprein, the copper protein from brain and chromaffin granules, was found to be a potent inhibitor of the hydroxylating activity of dopamine beta-monooxygenase, whereas the holoform of neurocuprein has no effect on the activity of the enzyme. The inhibiting capacity of neurocuprein may be due to th...

journal_title：Biochemical and biophysical research communications

authors： Markossian KA,Paitian NA,Mikaelyan MV,Nalbandyan RM

更新日期：1986-07-16 00:00:00

abstract：:Clinicians successfully utilize high uptake of radiolabeled glucose via PET scanning to localize metastases in melanoma patients. To take advantage of this altered metabolome, 3-bromopyruvate (BrPA) was used to overcome the notorious resistance of melanoma to cell death. Using four melanoma cell lines, BrPA triggered ...

journal_title：Biochemical and biophysical research communications

authors： Qin JZ,Xin H,Nickoloff BJ

更新日期：2010-05-28 00:00:00

abstract：:Calmodulin activation of target enzymes depends on the interaction between calmodulin hydrophobic regions and some enzyme areas. The Ca2+ induced exposure of calmodulin hydrophobic sites was studied by means of 2-p-toluidinylnaphthalene-6-sulfonate, a fluorescent probe. Scatchard and Job plots showed that the calmodul...

journal_title：Biochemical and biophysical research communications

authors： Follenius A,Gerard D

更新日期：1984-03-30 00:00:00

abstract：:The specific binding of leukotriene B4 to its receptor on human leukocyte membranes was enhanced in a dose-dependent manner by metal ions. Mg2+ and Ca2+ were the most potent followed by Mn2+ and Co2+. These divalent cations increased receptor density and did not affect the binding affinity. Addition of the same divale...

journal_title：Biochemical and biophysical research communications

authors： Ng CF,Haeggström JZ,Samuelsson B

更新日期：1997-07-18 00:00:00

abstract：:Thioredoxin (TRX) is one of major components of thiol reducing systems. To investigate the molecular mechanism of TRX function in the lung tissue, we screened a human lung epithelial cell cDNA library for TRX-binding protein by yeast two-hybrid systems. We isolated a plasmid containing C-propeptide region of human pro...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Masutani H,Nishiyama A,Hashimoto S,Gon Y,Horie T,Yodoi J

更新日期：2002-07-19 00:00:00

abstract：:Activation of protein kinase C delta (PKCδ) has been linked to the neuroinflammation but the relationship with the various neurodegenerative diseases including the Alzheimer's disease (AD) was mostly elusive. In the AD brains, the special phospholipids, ethanolamine plasmalogens (Pls), were found to be reduced and our...

journal_title：Biochemical and biophysical research communications

authors： Sejimo S,Hossain MS,Akashi K

更新日期：2018-09-05 00:00:00

abstract：:Simultaneous incubation of bovine adrenal medullary plasma membranes (PM) with chromaffin granules (CG) resulted in the release of the soluble granular content. The molecular mechanism of this process was studied with several monoclonal antibodies (mAb) raised against different plasma membrane components. Specific inh...

journal_title：Biochemical and biophysical research communications

authors： Bohner K,Boons J,Gheuens J,Konings F,De Potter WP

更新日期：1985-12-31 00:00:00

abstract：:Systemic sclerosis (SSc) or scleroderma is a generalized disorder of connective tissue. The etiology is poorly understood; however, both genetic and environmental factors have been implicated. To investigate the disease-susceptible gene for SSc, we examined the association of the disease with a gene (COL1A2) for type ...

journal_title：Biochemical and biophysical research communications

authors： Hata R,Akai J,Kimura A,Ishikawa O,Kuwana M,Shinkai H

更新日期：2000-05-27 00:00:00

abstract：:Extracellular acidic pH-activated chloride channel I(Cl, acid), has been characterized in HEK 293 cells and mammalian cardiac myocytes. This study was designed to characterize I(Cl,acid) in human umbilical vein endothelial cells(HUVECs). The activation and deactivation of the current rapidly and repeatedly follows the...

journal_title：Biochemical and biophysical research communications

authors： Ma ZY,Zhang W,Chen L,Wang R,Kan XH,Sun GZ,Liu CX,Li L,Zhang Y

更新日期：2008-07-04 00:00:00

abstract：:This study provides evidence for the presence of large conductance Ca(2+)-dependent K-channels in guinea pig and human urinary bladder smooth muscle. A23187, a Ca(2+)-ionophore, increased charybdotoxin and iberiatoxin sensitive 42K efflux in human urinary bladder smooth muscle cells, suggesting that large conductance ...

journal_title：Biochemical and biophysical research communications

authors： Trivedi S,Potter-Lee L,Li JH,Yasay GD,Russell K,Ohnmacht CJ,Empfield JR,Trainor DA,Kau ST

更新日期：1995-08-15 00:00:00

abstract：:Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under hypoxic conditions is the fundamental cause of pathological neovascularization in retinal ischemic diseases and cancers. Recent studies have shown that histone lysine demethylases (KDMs) play a key role in the amplification of HIF signali...

journal_title：Biochemical and biophysical research communications

authors： Vavilala DT,Ponnaluri VK,Vadlapatla RK,Pal D,Mitra AK,Mukherji M

更新日期：2012-06-08 00:00:00

abstract：:Reactive oxygen species (ROS) are crucial secondary messengers of signaling pathways. Redox-dependent signaling events have been previously described in the innate immune response. However, the mechanism by which ROS modulates anti-viral innate immune signaling is not fully clarified. Here, we report that mitochondria...

journal_title：Biochemical and biophysical research communications

authors： Gonzalez-Dosal R,Horan KA,Paludan SR

更新日期：2012-02-24 00:00:00

abstract：:Angiotensin II causes an increase of inositol phosphate production in cultured vascular smooth muscle cells from rat aorta. Pretreatment of the cells with pertussis toxin attenuates this effect. Pertussis toxin ADP-ribosylates a protein of about 40 kD in a crude membrane fraction. These data demonstrate the possible i...

journal_title：Biochemical and biophysical research communications

authors： Gaul G,Gierschik P,Marmé D

更新日期：1988-01-29 00:00:00

abstract：:The first several months of life are a critical period for neuronal plasticity in the visual cortex, during which anatomical and physiological development depends upon visual experience. Rearing in darkness slows the time course of this critical period, such that at 5 weeks normal cats are more plastic than dark-reare...

journal_title：Biochemical and biophysical research communications

authors： Yang C,Silver B,Ellis SR,Mower GD

更新日期：2001-10-12 00:00:00

abstract：:Ovarian clear cell carcinoma (OCCC) is an aggressive subtype of epithelial ovarian cancer, which generally exhibits chemoresistance. Effective therapy for OCCC is currently unavailable, requiring the development of new therapeutic strategies. ABT-263 (navitoclax), an inhibitor of the anti-apoptotic BCL-2/BCL-XL, has a...

journal_title：Biochemical and biophysical research communications

authors： Inoue-Yamauchi A,Oda H

更新日期：2020-06-04 00:00:00

abstract：:Staurosporine (STAR), a potent protein kinase C (PKC) antagonist, was found to modulate the chemoattractant-induced respiratory burst of human polymorphonuclear leukocytes (PMNs) according to drug concentration. Low STAR concentrations from 10 to 200 nM potentiated the N-formyl-methionyl-leucyl-phenylalanine (fMLP) an...

journal_title：Biochemical and biophysical research communications

authors： Combadière C,Hakim J,Giroud JP,Périanin A

更新日期：1990-04-16 00:00:00

abstract：:The induction of human BiP/GRP78 and GAPDH protein genes by the calcium ionophore A23187 was determined. Steady-state levels of mRNA for both the glucose starvation-responsive BiP/GRP78 gene and the glucose-responsive GAPDH gene were dramatically induced in a variety of human cells. There is a homologous palindromatic...

journal_title：Biochemical and biophysical research communications

authors： Chao CC,Yam WC,Lin-Chao S

更新日期：1990-08-31 00:00:00

abstract：:Epithelial cells form a globular organ-like multi-cellular structure called cyst when cultured in extracellular matrix. The cyst generates extension followed by cell chains and tubules in response to hepatocyte growth factor (HGF). The Rho family small GTPases play essential roles for tubulogenesis. FilGAP, a Rac spec...

journal_title：Biochemical and biophysical research communications

authors： Zuinen T,Tsutsumi K,Ohta Y

更新日期：2019-06-30 00:00:00

abstract：:The effect of silkworm hemolymph on baculovirus-induced insect cell apoptosis was investigated. The addition of silkworm hemolymph into the culture medium either before or during the baculovirus infection increased the host cell longevity; however, its addition after the infection was less effective. This can be expla...

journal_title：Biochemical and biophysical research communications

authors： Rhee WJ,Park TH

更新日期：2000-04-29 00:00:00

abstract：:A novel protein kinase activity was characterized from the cytosolic fraction of isolated rabbit gastric glands. The kinase phosphorylated a major 33,000 Da endogenous protein (pp33) and was stimulated by Zn2+ and Mn2+ with Kact of 1.0 and 7.5 mM, respectively. Mg2+ and Ca2+ failed to stimulate any pp33 kinase activit...

journal_title：Biochemical and biophysical research communications

authors： Goldenring JR,Oddsdottir M,Modlin IM

更新日期：1987-01-30 00:00:00

abstract：:Separation of proteins by two-dimensional electrophoresis and following mass spectrometry (MS) is now a conventional technique for proteomic analysis. For proteomic analysis of a certain tissue with a limited information of primary structures of proteins, we have developed an analytical system for peptide mass fingerp...

journal_title：Biochemical and biophysical research communications

authors： Hozumi A,Satouh Y,Ishibe D,Kaizu M,Konno A,Ushimaru Y,Toda T,Inaba K

更新日期：2004-07-09 00:00:00

abstract：:Lipopolysaccharide (LPS), an outer membrane component of Gram-negative bacteria, induces strong proinflammatory responses, including the release of cytokines and nitric oxide from macrophage. In this study, we found that a murine macrophage-derived line, RAW264.7, became multinuclear through cell-cell fusion after inc...

journal_title：Biochemical and biophysical research communications

authors： Nakanishi-Matsui M,Yano S,Matsumoto N,Futai M

更新日期：2012-08-24 00:00:00

abstract：:Connexin 43 (Cx43)-hemichannel activity is controlled by intramolecular interactions between cytoplasmic loop and C-terminal tail. We previously identified the last 10 amino acids of the C-terminal tail of Cx43 as essential for Cx43-hemichannel activity. We developed a cell-permeable peptide covering this sequence (TA...

journal_title：Biochemical and biophysical research communications

authors： D'hondt C,Iyyathurai J,Wang N,Gourdie RG,Himpens B,Leybaert L,Bultynck G

更新日期：2013-03-22 00:00:00

abstract：:In vivo electroporation and hydrodynamics-based gene delivery were utilized to test the effect of leptin gene transfer on food intake, and body and fat weights of mice. Gene transfer of pVRmob by electroporation caused a significant reduction in body weight compared with the control counterpart (p<0.05), although a le...

journal_title：Biochemical and biophysical research communications

authors： Xiang L,Murai A,Sugahara K,Yasui A,Muramatsu T

更新日期：2003-08-01 00:00:00

abstract：:Two genes that hybridize to the cDNA for alcohol-inducible cytochrome P-450 form 3a (P-450ALC) have been isolated from a rabbit genomic library and characterized by restriction mapping, hybridization, and partial sequence analysis. The genes show extensive sequence similarity as judged by hybridization at high stringe...

journal_title：Biochemical and biophysical research communications

authors： Khani SC,Porter TD,Coon MJ

更新日期：1988-01-15 00:00:00

abstract：:ASC2 structure has been well defined by 1141 NOE experimental restraints. The model consists of five alpha helices. alpha-Helices are connected by short random structure loops. The sole exception is the loop connecting helices 2 and 3, which has a 20-residue length. Folding generally agrees with the folding of recentl...

journal_title：Biochemical and biophysical research communications

authors： Espejo F,Patarroyo ME

更新日期：2006-02-17 00:00:00