Pertussis toxin inhibits angiotensin II-mediated phosphatidylinositol breakdown and ADP-ribosylates a 40 Kd protein in cultured smooth muscle cells.

abstract：:Some mutations in mitochondrial DNA (mtDNA) causing a number of neuromuscular diseases are suggested to arise spontaneously during the life of an individual. To substantiate the extent and the rate of these somatic mutations, mtDNA specimens from post-mortem human heart muscles of subjects in differing age groups were...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Hattori K,Sugiyama S,Ozawa T

更新日期：1992-12-15 00:00:00

abstract：:In pulse-chase experiments ([35S]Met as radioactive label) 4 intracellular forms of the alpha-subunit (apparent molecular weights of 11, 16.5, 19.5, and 23.4 kDa) were observed whereas almost no label was incorporated into the beta-subunit. The 23.4 kDa form was secreted as free alpha-subunit, the others were precurso...

journal_title：Biochemical and biophysical research communications

authors： Hilf G,Merz WE

更新日期：1989-02-28 00:00:00

abstract：:Consumption of a single serving of tomatoes by healthy human volunteers was sufficient to alter levels of oxidative DNA base damage in white cell DNA within 24 h. Levels of the mutagenic oxidized purine base 8-hydroxyguanine decreased, especially in those subjects whose initial levels of this base were higher than the...

journal_title：Biochemical and biophysical research communications

authors： Rehman A,Bourne LC,Halliwell B,Rice-Evans CA

更新日期：1999-09-07 00:00:00

abstract：:DNA fragmentation factors (DFF) form protein complexes consisting of nuclease DFF40/CAD and inhibitory chaperon DFF45/ICAD. Although activated caspase-3 has been shown to cleave DFF complexes with the release of active DFF40 and DNA fragmentation, the organ-specific mechanisms of DFF turnover during liver injury accom...

journal_title：Biochemical and biophysical research communications

authors： Xiang Y,Johnson EA,Zhang C,Huang G,Hayes RL,Wang KK,Svetlov SI

更新日期：2006-11-17 00:00:00

abstract：:A Golgi enriched fraction from rat brain was prepared. The preparation has no carboxypeptidase activity and is not contaminated with cytosol, mitochondria and lysosomes as judged by marker enzyme activities for these constituents. Associated with the Golgi membranes a putative opioid peptide processing activity was de...

journal_title：Biochemical and biophysical research communications

authors： Demmer W,Brand K

更新日期：1986-07-16 00:00:00

abstract：:The effects of isolated platelet surface membranes on DNA synthesis and proliferation of bovine coronary artery smooth muscle cells (SMC) were studied. Platelet membranes were very potent mitogens for SMC. The potency was about 10-fold higher than the maximum effects of platelet-derived growth factor-BB (PDGF). Platel...

journal_title：Biochemical and biophysical research communications

authors： Weber AA,Zucker TP,Schrör K

更新日期：1999-06-07 00:00:00

abstract：:Wnt-1, the vertebrate counterpart of the Drosophila wingless gene, plays an important role in the early morphogenesis of neural tissues. In this report, we have shown that overexpression of Wnt-1 can direct embryonic carcinoma P19 cells to differentiate into neuron-like cells in the absence of retinoic acid. Immunocyt...

journal_title：Biochemical and biophysical research communications

authors： Tang K,Yang J,Gao X,Wang C,Liu L,Kitani H,Atsumi T,Jing N

更新日期：2002-04-26 00:00:00

abstract：:The Znf131/ZNF131 protein belongs to the superfamily of POK proteins containing a BTB/POZ domain in its N-terminal part and 5 typical C2H2 zinc fingers and an additional C2HC zinc finger structure in its C-terminal region. In mouse and human two alternatively spliced transcripts are expressed from the Znf131/ZNF131 ge...

journal_title：Biochemical and biophysical research communications

authors： Trappe R,Buddenberg P,Uedelhoven J,Gläser B,Buck A,Engel W,Burfeind P

更新日期：2002-08-16 00:00:00

abstract：:The glutathione reductase gene, gor, was cloned from the plant pathogen Xanthomonas campestris pv. phaseoli. Its gene expression and enzyme characteristics were found to be different from those of previously studied homologues. Northern blot hybridization, promoter-lacZ fusion, and enzyme assay experiments revealed th...

journal_title：Biochemical and biophysical research communications

authors： Loprasert S,Whangsuk W,Sallabhan R,Mongkolsuk S

更新日期：2005-06-17 00:00:00

abstract：:Arginine-rich cell-penetrating peptides (CPPs) are promising carriers for the intracellular delivery of various bioactive molecules. However, many ambiguities remain about the molecular interplays on cell surfaces that ultimately lead to endocytic uptake of CPPs. By treatment of cells with octaarginine (R8), enhanced ...

journal_title：Biochemical and biophysical research communications

authors： Nakase I,Osaki K,Tanaka G,Utani A,Futaki S

更新日期：2014-04-18 00:00:00

abstract：:The effect of a cryptic splice acceptor (cSA) site located at the end of the extended packaging signal in murine leukemia virus (MLV)-based vectors was investigated. Although this cSA is also present in wild type MLV, it was found to result in a smaller transcript in which the packaging signal (Psi) had been removed b...

journal_title：Biochemical and biophysical research communications

authors： Pambalk K,Hohenadl C,Salmons B,Günzburg WH,Renner M

更新日期：2002-04-26 00:00:00

abstract：:The transcription factor sterol regulatory element-binding protein 1c (SREBP1c) plays an important role in the control of fatty acid metabolism in the liver. Evidence suggests that mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contributes to the regulation of SREBP1c expression, but signaling downstream of m...

journal_title：Biochemical and biophysical research communications

authors： Li S,Ogawa W,Emi A,Hayashi K,Senga Y,Nomura K,Hara K,Yu D,Kasuga M

更新日期：2011-08-26 00:00:00

abstract：:The immunoglobulin G of a polyclonal antiserum (pIgG) from a patient with insulin resistance and hypoglycemia was tested for its ability to inhibit insulin binding and to affect the autophosphorylation of partially-purified insulin receptors extracted from rat liver membranes. pIgG, when added 4 hr prior to insulin, i...

journal_title：Biochemical and biophysical research communications

authors： Cordera R,Gherzi R,De Pirro R,Rossetti L,Freidenberg GR,Andraghetti G,Lauro R,Adezati L

更新日期：1985-11-15 00:00:00

abstract：:The large ribosomal subunit of the thermophilic fungus Thermomyces lanuginosus was reconstructed in three dimensions from electron micrographs. This is the first reported reconstruction of the eukaryotic complex and demonstrates specific structural features such as an intersubunit canyon and a potential channel for th...

journal_title：Biochemical and biophysical research communications

authors： Harauz G,Zuzan H,Kim PT,Holbrook JA

更新日期：1995-02-15 00:00:00

abstract：:We describe the genomic organization and the functional promoter of the monocyte specific gene Dif-2, the human homologue to genes in mouse (gly96) and rat (PRG1), that is downregulated during cell differentiation. The Dif-2 gene consists of two exons and a single intron of 112 bp in length. RNase protection assay ind...

journal_title：Biochemical and biophysical research communications

authors： Pietzsch A,Büchler C,Schmitz G

更新日期：1998-04-28 00:00:00

abstract：:A recent report has shown that in vitro the RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. However, in vivo, it is well known that CGRP receptors are expressed in human coronary arteries and that a beneficial effect is observed in patients after CGRP i...

journal_title：Biochemical and biophysical research communications

authors： Frayon S,Cueille C,Gnidéhou S,de Vernejoul MC,Garel JM

更新日期：2000-04-21 00:00:00

abstract：:In order to investigate the utility of intranasal administration of peptides for systemic medication, the nasal absorption of the model peptide, leucine enkephalin (Tyr-Gly-Gly-Phe-Leu), was studied in the rat. At a concentration of 60 micrograms/ml in Ringer's buffer the pentapeptide was found to undergo, extensive h...

journal_title：Biochemical and biophysical research communications

authors： Hussain A,Faraj J,Aramaki Y,Truelove JE

更新日期：1985-12-31 00:00:00

abstract：:Oxidized low-density lipoprotein (ox-LDL) is a critical mediator of atherogenesis. Macrophage uptake of ox-LDL and their subsequent development into foam cells is the principal event in atherosclerosis. Interleukin-1β (IL-1β), a prototypic multifunctional cytokine involved in inflammation, has an important effect on t...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Wang M,Huang K,Zhang Z,Shao N,Zhang Y,Wang W,Wang S

更新日期：2012-08-24 00:00:00

abstract：:Drosophila DLG (Discs Large Tumor Suppresser Protein) is a component of septate junctions, and disruption of its gene leads to over growth of imaginal discs. Homologs of Drosophila DLG recently isolated from mammalian tissue have been classified as members of the MAGUK (Membrane Associated GUanylate Kinase) superfamil...

journal_title：Biochemical and biophysical research communications

authors： Inagaki H,Maeda S,Lin KH,Shimizu N,Saito T

更新日期：1999-11-19 00:00:00

abstract：:The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for a...

journal_title：Biochemical and biophysical research communications

authors： Winberg ME,Motlagh MK,Stenkula KG,Holm C,Jones HA

更新日期：2014-04-18 00:00:00

abstract：:Airway viral infection disturbs the health-related quality of life. B7-H1 (also known as PD-L1) is a coinhibitory molecule associated with the escape of viruses from the mucosal immunity, leading to persistent infection. Most respiratory viruses generate double-stranded (ds) RNA during replication. The stimulation of ...

journal_title：Biochemical and biophysical research communications

authors： Kan-o K,Matsumoto K,Asai-Tajiri Y,Fukuyama S,Hamano S,Seki N,Nakanishi Y,Inoue H

更新日期：2013-05-31 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene's promoter. We have previously demonstrated that VDR binds in vitro with high affinity to the 5'-flanking sequence of...

journal_title：Biochemical and biophysical research communications

authors： Seoane S,Alonso M,Segura C,Pérez-Fernández R

更新日期：2002-03-22 00:00:00

abstract：:COMPARE computer program suggested that benzamide riboside, BR, 3-(1-deoxy-beta-D-ribofuranosyl)benzamide, should have a similar mechanism of action as that of tiazofurin, an inhibitor of IMP dehydrogenase (IMPDH). This hypothesis was tested in K562 cells in culture. BR was cytotoxic to K562 cells with an IC50 of 2 mi...

journal_title：Biochemical and biophysical research communications

authors： Jayaram HN,Gharehbaghi K,Jayaram NH,Rieser J,Krohn K,Paull KD

更新日期：1992-08-14 00:00:00

abstract：:Murine interleukin 6 (mIL-6) has been synthesized as a fusion protein using a lac operon inducible plasmid in Escherichia coli. The first 8 amino acids are from the N-terminus of bacterial beta-galactosidase and the last 175 amino acids are from residue number 12 to the end of native mIL-6. This fusion protein is equi...

journal_title：Biochemical and biophysical research communications

authors： Simpson RJ,Moritz RL,Van Roost,Van Snick J

更新日期：1988-11-30 00:00:00

abstract：:In calf thymus an alpha-D-galactosyltransferase activity has been detected that transfers galactosyl residues from UDP-galactose to suitable acceptors having galactose at the non-reducing terminus. For example, incubation of UDP-[14C]galactose and Gal beta(1 leads to 4) GlcNAc (N-acetyllactosamine) in the presence of ...

journal_title：Biochemical and biophysical research communications

authors： Van Halbeek H,Vliegenthart JF,Winterwerp H,Blanken WM,Van den Eijnden DH

更新日期：1983-01-14 00:00:00

abstract：:Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect. Initially we found that triglyceride turnover was faster in hAPOA5 transgenic mice compared to controls, and this strongly correlated w...

journal_title：Biochemical and biophysical research communications

authors： Fruchart-Najib J,Baugé E,Niculescu LS,Pham T,Thomas B,Rommens C,Majd Z,Brewer B,Pennacchio LA,Fruchart JC

更新日期：2004-06-25 00:00:00

abstract：:Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases but its etiology is unclear. Alpha-synuclein (alpha-SN) is a major component of Lewy bodies and Lewy neurites, and its missense mutations, A30P and A53T, cause familial PD. In PD, alpha-SN-positive glial inclusions are distributed mainly ...

journal_title：Biochemical and biophysical research communications

authors： Kohno R,Sawada H,Kawamoto Y,Uemura K,Shibasaki H,Shimohama S

更新日期：2004-05-21 00:00:00

abstract：:The non-receptor tyrosine kinases c-Src and focal adhesion kinase (Fak) mediate signal transduction pathways that regulate cell proliferation, survival, invasion, and metastasis. Here, we investigated whether c-Src and Fak are activated during progression of hormone-dependent breast cancer. Maximally active c-Src was ...

journal_title：Biochemical and biophysical research communications

authors： Planas-Silva MD,Bruggeman RD,Grenko RT,Stanley Smith J

更新日期：2006-03-03 00:00:00

abstract：:ERRalpha (estrogen receptor-related receptor alpha) is a member of the nuclear receptor superfamily. To further our understanding of the detailed molecular mechanism of transcriptional regulation by ERRalpha, we searched for ERRalpha-interacting proteins using a yeast two-hybrid system by screening a human mammary gla...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Chen B,Chen J,Lou G,Chen S,Zhou D

更新日期：2008-05-16 00:00:00

abstract：:While the appetite-stimulating hormone ghrelin can act to acutely modulate electrical activity of neurons in the appetite regulating network, it also has a role in regulating neuronal outgrowth, synaptic connectivity and intrinsic electrophysiological properties. In this study, we investigated whether ghrelin may caus...

journal_title：Biochemical and biophysical research communications

authors： Huang S,Lee SA,Oswald KE,Fry M

更新日期：2015-10-30 00:00:00