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Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells.

Abstract：

:Wnt-1, the vertebrate counterpart of the Drosophila wingless gene, plays an important role in the early morphogenesis of neural tissues. In this report, we have shown that overexpression of Wnt-1 can direct embryonic carcinoma P19 cells to differentiate into neuron-like cells in the absence of retinoic acid. Immunocytochemistry showed that these cells expressed neuronal markers, such as the neurofilament (NF) and microtubule-associated protein 2 (MAP2), but failed to express the glial cell marker, glial fibrillary acidic protein (GFAP). RT-PCR revealed that two basic helix-loop-helix (bHLH) genes, Mash-1 and Ngn-1, were up-regulated during the differentiation stage of Wnt-1-overexpressing P19 cells. These results suggest that the Wnt-1 gene promotes neuronal differentiation and inhibits gliogenesis during the neural differentiation of P19 cells, and that neural bHLH genes might be involved in this process.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tang K,Yang J,Gao X,Wang C,Liu L,Kitani H,Atsumi T,Jing N

doi

10.1016/S0006-291X(02)00215-2

subject

Has Abstract

pub_date

2002-04-26 00:00:00

pages

167-73

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(02)00215-2

journal_volume

293

pub_type

杂志文章

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