CK2 regulates in vitro the activity of the yeast cyclin-dependent kinase inhibitor Sic1.

abstract：:Human untranslated region (UTR) databases were searched to identify novel proteins potentially regulated by an iron responsive element (IRE), and found two candidates-cell cycle phosphatase Cdc14A variant 1 and myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCKalpha), both possessing a putative IRE in ...

journal_title：Biochemical and biophysical research communications

authors： Cmejla R,Petrak J,Cmejlova J

更新日期：2006-03-03 00:00:00

abstract：:The major interaction site for tumor-promoting phorbol esters is the calcium-activated, phospholipid-dependent protein kinase (protein kinase C), a key-element in signal transduction. Binding of phorbol esters results in enzyme activation which mediates, at least in part, the action of these agents. We have investigat...

journal_title：Biochemical and biophysical research communications

authors： Roghani M,Da Silva C,Castagna M

更新日期：1987-02-13 00:00:00

abstract：:Here we describe the cDNA structure, genomic organization, chromosomal localization, and promoter analysis of the mouse peptide transporter PEPT2. The PEPT2-cDNA is 3987 bp long and encodes a protein of 729 amino acids. The functional properties, analyzed by expression in Xenopus laevis oocytes, showed a typical PEPT2...

journal_title：Biochemical and biophysical research communications

authors： Rubio-Aliaga I,Boll M,Daniel H

更新日期：2000-09-24 00:00:00

abstract：:To elucidate whether p21waf-1/cip-1/sdi-1 expression is associated with loss of growth potential of hepatocytes of old rats, we determined p21waf-1/cip-1/sdi-1 expression of hepatocytes from old (30 months) rats during the cell cycle in primary culture. A high level of expression of p21waf-1/cip-1/sdi-1 was detected a...

journal_title：Biochemical and biophysical research communications

authors： Sawada N,Kojima T,Obata H,Saitoh M,Isomura H,Kokai Y,Satoh M,Mori M

更新日期：1996-11-21 00:00:00

abstract：:We previously reported transplantation of brain microvascular endothelial cells (MVECs) into cerebral white matter infarction model improved the animal's behavioral outcome by increasing the number of oligodendrocyte precursor cells (OPCs). We also revealed extracellular vesicles (EVs) derived from MVECs promoted surv...

journal_title：Biochemical and biophysical research communications

authors： Osawa S,Kurachi M,Yamamoto H,Yoshimoto Y,Ishizaki Y

更新日期：2017-06-17 00:00:00

abstract：:The cobalt(II) derivative of cucumber basic blue copper protein "plantacyanin" has been prepared. The visible absorption, circular dichroic and magnetic circular dichroic spectra of Co(II)-plantacyanin are similar to those of Co(II)-plastocyanin, indicating that the stereochemistry of Co(II) is tetrahedral and at leas...

journal_title：Biochemical and biophysical research communications

authors： Sakurai T

更新日期：1986-09-30 00:00:00

abstract：:Interleukin-4 (IL-4) is a pleiotropic immunomodulatory cytokine produced mainly by T lymphocyte. It is known that many kinds of non-haematopoietic cells, as well as immune cells and haematopoietic cells, express IL-4 receptors. Recently, we found that IL-4 increased hydroxyproline and osteocalcin accumulation and caus...

journal_title：Biochemical and biophysical research communications

authors： Ishibashi H,Karube S,Yamakawa A,Koshihara Y

更新日期：1995-06-26 00:00:00

abstract：:T cell immunotherapies are promising options in leukemia, among which the CD19/CD3-bispecific T cell engager antibody blinatumomab (MT103) has shown high response rates at very low doses in patients with lymphoma. However, the high CD47 expression in human lymphoma cells has limited the curative effects of blinatumoma...

journal_title：Biochemical and biophysical research communications

authors： Xu L,Wang S,Li J,Li B

更新日期：2019-02-12 00:00:00

abstract：:We compared the nitric oxide (NO)-generating behavior of nitroglycerin (NTG), pentaerythritol trinitrate (PEtriN) and isosorbide dinitrate (ISDN), in the microsomal preparation of bovine coronary artery smooth muscle cells. The comparative NO generating activities among these nitrates were consistent with their relati...

journal_title：Biochemical and biophysical research communications

authors： Chung SJ,Fung HL

更新日期：1992-06-30 00:00:00

abstract：:The purpose of this study was to identify mammalian cell line(s) which possess intrinsic enzymatic activity of beta-carotene 15, 15'-dioxygenase. This enzyme (EC1.13.11.21) converts beta-carotene to retinal (precursor of retinol and retinoic acid). To assess activity, cellular enzyme preparations were incubated with b...

journal_title：Biochemical and biophysical research communications

authors： During A,Albaugh G,Smith JC Jr

更新日期：1998-08-19 00:00:00

abstract：:We report the isolation of a gene encoding a novel member of the family of melanocortin receptors. The mouse melanocortin-5 receptor (mMC5R) responds to melanocortins with an increase in intracellular cyclic 3',5'-adenosine monophosphate (cAMP) concentrations. Stimulation of the mMC5R by the melanocortins revealed a h...

journal_title：Biochemical and biophysical research communications

authors： Gantz I,Shimoto Y,Konda Y,Miwa H,Dickinson CJ,Yamada T

更新日期：1994-05-16 00:00:00

abstract：:Information on the immune response against H5N1 within the lung is lacking. Here we describe the sustained antiviral immune responses, as indicated by the expression of MxA protein and IFN-alpha mRNA, in autopsy lung tissue from an H5N1-infected patient. H5N1 infection of primary bronchial/tracheal epithelial cells an...

journal_title：Biochemical and biophysical research communications

authors： Thitithanyanont A,Engering A,Uiprasertkul M,Ekchariyawat P,Wiboon-Ut S,Kraivong R,Limsalakpetch A,Kum-Arb U,Yongvanitchit K,Sa-Ard-Iam N,Rukyen P,Mahanonda R,Kawkitinarong K,Auewarakul P,Utaisincharoen P,Sirisinha S,Mason

更新日期：2010-08-06 00:00:00

abstract：:Previous structural and mutational studies of bovine pancreatic deoxyribonuclease I (bpDNase I) have demonstrated that the active site His134 and His252 played critical roles in catalysis. In our present study, mutations of these two His residues to Gln, Ala or Gly reduced the DNase activity by a factor of four to fiv...

journal_title：Biochemical and biophysical research communications

authors： Chen WJ,Lai PJ,Lai YS,Huang PT,Lin CC,Liao TH

更新日期：2007-01-19 00:00:00

abstract：:Sulfoquinovosyl diacylglycerol is one of the lipids that construct thylakoid membranes, and is distributed from cyanobacteria to plastids in plants including a red lineage. One of the most primitive red algae, Cyanidioschyzon melorae, similar to cyanobacteria and green plants, possesses homologs of the SQD1 and SQD2 g...

journal_title：Biochemical and biophysical research communications

authors： Sato N,Kobayashi S,Aoki M,Umemura T,Kobayashi I,Tsuzuki M

更新日期：2016-01-29 00:00:00

abstract：:Earlier, we showed that antibodies specific for human serum albumin are able to bind to erythrocyte-associated albumin and inhibit complement mediated hemolysis. In the present study we determine if inhibition is occurring at the membrane attack phase of complement activation or at an earlier step. We show that althou...

journal_title：Biochemical and biophysical research communications

authors： Houle JJ,Hoffmann EM

更新日期：1994-04-15 00:00:00

abstract：:Inflammation has an essential role in regulating the pathogenesis of acute respiratory distress syndrome (ARDS). The serine/threonine kinase PIM2 is highly expressed in human macrophages, and exhibits regulatory role in inflammatory response. However, its effect on ARDS progression has not been investigated and still ...

journal_title：Biochemical and biophysical research communications

authors： Wang F,Xu L,Dong G,Zhu M,Liu L,Wang B

更新日期：2020-12-17 00:00:00

abstract：:IL-13 mediates its effects through a complex receptor system including IL-4Ralpha and a functional IL-13Ralpha1. IL-13 has been reported to have no effects on mouse B cells due to a lack of receptor expression. However, on human B cells a functional IL-13Ralpha1 has been described. Here, we identified the rat IL-13Ral...

journal_title：Biochemical and biophysical research communications

authors： Pierrot C,Beniguel L,Bègue A,Khalife J

更新日期：2001-10-05 00:00:00

abstract：:The 32/20-kDa two-chain form of protective protein/cathepsin A (CathA) secreted by human platelets was thermostable in the aggregation supernatant at acidic pH, but was denatured at neutral pH. Leupeptin partly protected the CathA against denaturation, which was not observed in the supernatant after depletion of the c...

journal_title：Biochemical and biophysical research communications

authors： Itoh K,Naganawa Y,Kamei S,Shimmoto M,Sakuraba H

更新日期：1998-12-18 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are newly identified, potent producers of type 2 cytokines, such as IL-5 and IL-13, and contribute to the development of allergic lung inflammation induced by cysteine proteases. Although it has been shown that inducible costimulator (ICOS), a costimulatory molecule, is expressed ...

journal_title：Biochemical and biophysical research communications

authors： Kamachi F,Isshiki T,Harada N,Akiba H,Miyake S

更新日期：2015-08-07 00:00:00

abstract：:miR-183 cluster, composed of miR-183/-96/-182 genes, is highly expressed in the adult retina, particularly in photoreceptors. It involves in development, maturation and normal function of neuroretina. Ectopic overexpression of miR-183/-96/-182 genes was performed to assess reprogramming of hRPE cells. They were amplif...

journal_title：Biochemical and biophysical research communications

authors： Davari M,Soheili ZS,Samiei S,Sharifi Z,Pirmardan ER

更新日期：2017-01-29 00:00:00

abstract：:The influence of leucine starvation on the subcellular location of leucyl-tRNA synthetase in Escherichia coli was examined in a leucine auxotrophic strain by sucrose density sedimentation analysis. Analysis of the subcellular distribution of leucyl-tRNA synthetase activity revealed that during unrestricted growth, the...

journal_title：Biochemical and biophysical research communications

authors： Williamson RM

更新日期：1993-02-15 00:00:00

abstract：:When small amounts (1 microgram) of lipopolysaccharide (LPS) purified from Salmonella minnesota (SM) wild, SM R60 and SM R345 were intravenously injected into mice 7 days after heat-killed Propionibacterium acnes was intravenously injected, massive hepatic cell necrosis was induced and most of the mice died within 24 ...

journal_title：Biochemical and biophysical research communications

authors： Mizoguchi Y,Sakagami Y,Kuboi H,Kobayashi K,Yano I

更新日期：1988-09-30 00:00:00

abstract：:Eight amino acid permease genes from the protozoan parasite Leishmania donovani (AAPLDs) were cloned, sequenced, and shown to be expressed in promastigotes. Seven of these belong to the amino acid transporter-1 and one to the amino acid polyamino-choline superfamilies. Using these sequences as well as known and charac...

journal_title：Biochemical and biophysical research communications

authors： Akerman M,Shaked-Mishan P,Mazareb S,Volpin H,Zilberstein D

更新日期：2004-12-03 00:00:00

abstract：:Polynuclear aromatic hydrocarbons (PAH) represent a large class of chemicals present in environment. We have used yeast strain ER(wt) expressing human estrogen receptor (hER) and an estrogen-sensitive reporter to characterize the estrogenic or anti-estrogenic activities of 21 PAHs. The PAHs did not exhibit estrogenic ...

journal_title：Biochemical and biophysical research communications

authors： Tran DQ,Ide CF,McLachlan JA,Arnold SF

更新日期：1996-12-04 00:00:00

abstract：:Increasing evidence has shown that miRNAs are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. In this study, we confirmed that miR-214 is frequently down-regulated in cervical cancer compared with normal cervical tissues. Ectopic expression of miR-214 suppressed p...

journal_title：Biochemical and biophysical research communications

authors： Peng R,Men J,Ma R,Wang Q,Wang Y,Sun Y,Ren J

更新日期：2017-03-11 00:00:00

abstract：:Rapid emergence of multi-drug resistance in Mycobacterium tuberculosis has necessitated the development of newer candidate drugs which can selectively inhibit the growth of the organism. Among the best targets available today, transcription machinery is, by far, the most important one and the antibiotic rifampicin bin...

journal_title：Biochemical and biophysical research communications

authors： Mukherjee R,Chatterji D

更新日期：2008-05-09 00:00:00

abstract：:Cytokine induced pancreatic beta-cell destruction seen in Type 1 diabetes and islet graft rejection involves multiple intracellular signaling pathways that directly or indirectly lead to inflammatory damage or programmed cell death. IL-1beta has been shown to stimulate the 12-lipoxygenase pathway product 12-HETE, in R...

journal_title：Biochemical and biophysical research communications

authors： Bleich D,Chen S,Wen Y,Nadler JL

更新日期：1997-01-13 00:00:00

abstract：:Antithrombin III (ATIII) performs a critical anticoagulant function by precluding the activation of blood clotting proteinases, aided by its two cofactors, heparin and heparan sulfate. Though several studies have been carried out on physiological, biochemical and structural perspectives on ATIII, so far there are limi...

journal_title：Biochemical and biophysical research communications

authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

更新日期：2013-11-01 00:00:00

abstract：:Arl13b is an atypical Arf/Arl-family GTPase consisting of an extending large C-terminal region (C domain) and Arf-homologous GTP-binding motifs in the N terminus (N domain). Although Arl13b appears to be involved in cilia formation, its precise function and roles of the domains remain unknown. Here, we show the unique...

journal_title：Biochemical and biophysical research communications

authors： Hori Y,Kobayashi T,Kikko Y,Kontani K,Katada T

更新日期：2008-08-15 00:00:00

abstract：:Electroporation is the most widely employed method of gene transfer into macrophages which are hard to transfect. RAW 264.7 is a widely used cell line for studying macrophage responses. Electroporation of RAW 264.7 cells with commercial reagents although very efficient is expensive necessitating the development of cos...

journal_title：Biochemical and biophysical research communications

authors： Alamuru-Yellapragada NP,Kapadia B,Parsa KVL

更新日期：2017-05-27 00:00:00