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miR-214 down-regulates ARL2 and suppresses growth and invasion of cervical cancer cells.

Abstract：

:Increasing evidence has shown that miRNAs are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. In this study, we confirmed that miR-214 is frequently down-regulated in cervical cancer compared with normal cervical tissues. Ectopic expression of miR-214 suppressed proliferation, migration and invasion of HeLa and C33A cervical cancer cells. Bioinformatics analysis revealed that ADP ribosylation factor like 2 (ARL2) was a potential target of miR-214 and was remarkably up-regulated in cervical cancer. Knockdown of ARL2 markedly inhibited cervical cancer cell proliferation, migration and invasion, similarly to over-expression of miR-214, indicating that ARL2 may function as an oncogene in cervical cancer. In conclusion, our study revealed that miR-214 acts as a tumor suppressor via inhibiting proliferation, migration and invasion of cervical cancer cells through targeting ARL2, and that both miR-214 and ARL2 may serve as prognostic or therapeutic targets for cervical cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Peng R,Men J,Ma R,Wang Q,Wang Y,Sun Y,Ren J

doi

10.1016/j.bbrc.2017.01.152

subject

Has Abstract

pub_date

2017-03-11 00:00:00

pages

623-630

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)30220-6

journal_volume

484

pub_type

杂志文章

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