P21waf-1/cip-1/sdi-1 is expressed at G1 phase in primary culture of hepatocytes from old rats, presumably preventing the cells from entering the S phase of the cell cycle.

abstract：:Polyribosomes were isolated without the use of detergents, irradiated with ultraviolet light and labelled in the presence of (gamma-32P) adenosine 5'-triphosphate. Poly(A)+RNA-protein structures separated by chromatography on oligo (dT)-cellulose contained up to 1o crosslinked proteins as shown by SDS-polyacrylamide g...

journal_title：Biochemical and biophysical research communications

authors： Schweiger A,Kostka G,Weiss E

更新日期：1986-04-14 00:00:00

abstract：:The Sir proteins, namely Sir2, 3 and 4, have roles related to heterochromatin, but genome-wide studies have revealed their presence at many euchromatic loci, although the functional meaning of this is still not clear. Nhp6a is an abundant HMG-like protein in yeast, which has a role in transcription by modulating chrom...

journal_title：Biochemical and biophysical research communications

authors： Ciuffetta A,Salerno D,Camilloni G,Venditti S

更新日期：2015-05-22 00:00:00

abstract：:In the areas of North Africa, Southeast Asia as well as South China, Nasopharyngeal carcinoma (NPC) is among the most widespread cancers. Plenty of research findings confirmed that Epstein-Barr virus (EBV) played a crucial role in NPC. EBV-encoded Latent membrane protein 2A (LMP2A) which continuously expressed in cell...

journal_title：Biochemical and biophysical research communications

authors： Cao Q,Zhang D,Mao Y,Meng C,Zhu J,Feng Z,Chen R

更新日期：2017-01-08 00:00:00

abstract：:The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selective anti-herpes-virus compound. In order to synthesize and study the properties of a DNA that contains C-BVDU, the 5'-triphosphate, C-BVDUTP was prepared and evaluated as a potential substrate of the E. coli Klenow DNA...

journal_title：Biochemical and biophysical research communications

authors： Sági J,De Clercq E,Szemzö A,Csárnyi A,Kovács T,Otvös L

更新日期：1987-09-30 00:00:00

abstract：:Despite decades of intensive studies, the failure to identify plasmodesmata (PD) localization sequences has constrained our understanding of Tobacco mosaic virus (TMV) movement. Recently, we identified the first PD localization signal (major PLS) in the TMV movement protein (MP), which encompasses the first 50 amino a...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Huang C,Zeng J,Yu H,Li Y,Yuan C

更新日期：2020-01-01 00:00:00

abstract：:Proadrenomedullin N-terminal 20 peptide (PAMP) is a regulatory peptide that is found in various cell types. It is involved in many biological activities and is rich in basic and hydrophobic amino acids, a common feature of antimicrobial peptides (AMPs). In this study, the cell selectivity and antimicrobial mechanism o...

journal_title：Biochemical and biophysical research communications

authors： Ajish C,Yang S,Kumar SD,Shin SY

更新日期：2020-06-30 00:00:00

abstract：:The maximal activity of the enzymes hexokinase and 6-phosphofructokinase were measured in interscapular brown adipose tissue during ageing in the rat. The activity of these glycolytic enzymes increased markedly during the suckling-weaning transition (20-22 days of age), but from 30 to 100 days of age the activities pe...

journal_title：Biochemical and biophysical research communications

authors： Simpson ML,Cooney GJ,Caterson ID,Newsholme EA

更新日期：1986-10-15 00:00:00

abstract：:Sequence analysis of a new lignin peroxidase (LIP) gene, GLG6, from P. chrysosporium showed that it encodes a mature LIP protein with a predicted Mr of 36,454. A 28 aa signal peptide precedes the mature protein. The coding region of GLG6 is interrupted by nine introns ranging in size from 50-57 bp. GLG6 encoded-LIP ha...

journal_title：Biochemical and biophysical research communications

authors： Naidu PS,Zhang YZ,Reddy CA

更新日期：1990-12-31 00:00:00

abstract：:The effects of fibroblast growth factor (FGF) on testicular aromatase activity has been studied using primary cultures of porcine Leydig cells. After culture for 3 days in the absence or presence of FGF, the ability of the cells to produce estrogen was examined in a 4h-test period in which either (a) hCG (10(-9) M) or...

journal_title：Biochemical and biophysical research communications

authors： Raeside JI,Berthelon MC,Sanchez P,Saez JM

更新日期：1988-02-29 00:00:00

abstract：:A guinea pig adrenal hydroxysteroid sulfotransferase (gpHST2) has been cloned that is distinct from guinea pig hydroxysteroid sulfotransferase that stereoselectively acts on 3 alpha-hydroxylated neutral steroids (gp3 alpha HST, redesignated gpHST1). The deduced amino acid sequences for gpHST1 and gpHST2 are 86% identi...

journal_title：Biochemical and biophysical research communications

authors： Luu NX,Driscoll WJ,Martin BM,Strott CA

更新日期：1995-12-26 00:00:00

abstract：:Human bone marrow cells express both a truncated and full-length form of the erythropoietin receptor (EpoR-T and EpoR-F, respectively). Transfection experiments using the murine interleukin (IL)-3-dependent cell line, Ba/F3, revealed that the cells coexpressing EpoR-F and EpoR-T (Ba/F3-FT) were more likely to undergo ...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Komatsu N,Nakamura Y,Nakauchi H,Nakabeppu Y,Miura Y

更新日期：1996-05-06 00:00:00

abstract：:Replacement of leucine in the chemotactic peptide For-Met-Leu-Phe by the sterically constrained amino acids alpha-aminoisobutyric acid and aminocyclohexanecarboxylic acid affords compounds of equal or greater activity than the parent. NMR studies indicate that the parent compound is present as a beta-sheet in solution...

journal_title：Biochemical and biophysical research communications

authors： Semus SF,Becker EL,Toniolo C,Freer RJ

更新日期：1988-12-15 00:00:00

abstract：:Pumilio is a member of the highly conserved PUF family of RNA-binding proteins that function as a developmental regulator in diverse animal species. Two Pumilio genes, Pum1 and Pum2, have been identified in mammals and are found to be involved in sperm development, neuron development as well as human diseases such as ...

journal_title：Biochemical and biophysical research communications

authors： Zhang C,Zhu T,Chen Y,Xu EY

更新日期：2015-06-19 00:00:00

abstract：:The Ca(2+)-binding proteins regulate a number of cellular and extracellular activities and deregulations of S100 gene expression are associated with several human diseases. For example, S100A7 is upregulated in psoriatic skin, implicating a link with psoriasis, a chronic inflammatory dermatosis. We purified human S100...

journal_title：Biochemical and biophysical research communications

authors： Bürgisser DM,Siegenthaler G,Kuster T,Hellman U,Hunziker P,Birchler N,Heizmann CW

更新日期：1995-12-05 00:00:00

abstract：:The production of 1 alpha,25-dihydroxyvitamin D3 is known to be down regulated by 1 alpha,25-dihydroxyvitamin D3 itself. It was recently shown that liver mitochondrial sterol 27-hydroxylase CYP27, present also in kidney, catalyzes 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Treatment of vitamin D-deficient rats wit...

journal_title：Biochemical and biophysical research communications

authors： Axén E,Postlind H,Wikvall K

更新日期：1995-10-04 00:00:00

abstract：:The x-ray absorption near edge structure (XANES) spectra of hemoglobin and myoglobin have been measured at the wiggler beam line of the Frascati Synchrotron Radiation Facility. The energy shifts of the iron absorption jump edge and the chemical shifts of the bound excited state at threshold of 1s core excitations, goi...

journal_title：Biochemical and biophysical research communications

authors： Bianconi A,Congiu-Castellano A,Dell'Ariccia M,Giovannelli A,Burattini E,Durham PJ

更新日期：1985-08-30 00:00:00

abstract：:The adenine nucleotide translocase (ANT), besides transferring ATP from the mitochondrial matrix to the rest of the cell, has also been proposed to be involved in mitochondrial permeability transition (MPT), and accordingly in mitochondrial Ca2+ homeostasis. In order to assess the role of ANT in Ca2+ signal transmissi...

journal_title：Biochemical and biophysical research communications

authors： Wieckowski MR,Szabadkai G,Wasilewski M,Pinton P,Duszyński J,Rizzuto R

更新日期：2006-09-22 00:00:00

abstract：:Fura-2 loaded pancreatic beta-cells, isolated from obese hyperglycemic mice, were studied with respect to cytoplasmic free Ca2+ concentration ([Ca2+]i), insulin release and efflux of indicator. In the absence of glucose there was a continuous efflux of fura-2, which was markedly increased by stimulation with a high co...

journal_title：Biochemical and biophysical research communications

authors： Arkhammar P,Nilsson T,Berggren PO

更新日期：1989-02-28 00:00:00

abstract：:MazF is a sequence-specific endoribonuclease or mRNA interferase, which cleaves RNA at a specific sequence. Since the expression of a specific gene or a group of specific genes can be regulated by MazF, expanding the repertoire of recognition sequences by MazF mRNA interferases is highly desirable for biotechnological...

journal_title：Biochemical and biophysical research communications

authors： Ishida Y,Inouye K,Ming O,Inouye M

更新日期：2019-10-20 00:00:00

abstract：:The synthesis of toxin protein from Ustilago maydis virus (UmV) strain P4 was studied in vitro and in vivo. The protein synthesized in vitro and in vivo has a molecular weight of approximately 30 kd whereas the native toxin has a molecular weight of about 12 kd. In the presence of protease inhibitors and glycosylation...

journal_title：Biochemical and biophysical research communications

authors： Podila GK,Bozarth RF,Flurkey WH

更新日期：1987-12-16 00:00:00

abstract：:Polycystin-1 (PC1) is a membrane protein expressed in tubular epithelia of developing kidneys and in other ductal structures. Recent studies indicate this protein to be putatively important in regulating intracellular Ca(2+) levels in various cell types, but little evidence exists for kidney epithelial cells. Here we ...

journal_title：Biochemical and biophysical research communications

authors： Aguiari G,Campanella M,Manzati E,Pinton P,Banzi M,Moretti S,Piva R,Rizzuto R,del Senno L

更新日期：2003-02-14 00:00:00

abstract：:Leptin and its receptors are overexpressed in breast cancer tissues and correlate with poor prognosis. Survivin, a member of the inhibitor of apoptosis protein (IAP) gene family, is generally upregulated in tumor tissues and prevents tumor cells from apoptosis. Here we showed that leptin upregulated survivin mRNA and ...

journal_title：Biochemical and biophysical research communications

authors： Jiang H,Yu J,Guo H,Song H,Chen S

更新日期：2008-03-28 00:00:00

abstract：:Low density lipoprotein (LDL) is readily oxidized under certain conditions, resulting in the formation of oxidized LDL (oxLDL). Despite numerous in vitro reports that reveal the pathogenic role of oxidative stress, anti-oxidative strategies have underperformed in the clinic. In this study, we examine the role of oxLDL...

journal_title：Biochemical and biophysical research communications

authors： Kim OS,Lee CS,Joe EH,Jou I

更新日期：2006-03-31 00:00:00

abstract：:p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with "gain of function" (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different endogenous p53 muta...

journal_title：Biochemical and biophysical research communications

authors： Vaughan CA,Frum R,Pearsall I,Singh S,Windle B,Yeudall A,Deb SP,Deb S

更新日期：2012-11-09 00:00:00

abstract：:Ghrelin, a gastric-derived peptide, has recently been identified as an endogenous natural ligand for the growth hormone (GH) secretagogue receptor. However, secretory characteristics of ghrelin are still obscure in ruminants. To investigate the diurnal rhythm in ghrelin secretion and its relationship to GH secretion, ...

journal_title：Biochemical and biophysical research communications

authors： Sugino T,Hasegawa Y,Kikkawa Y,Yamaura J,Yamagishi M,Kurose Y,Kojima M,Kangawa K,Terashima Y

更新日期：2002-07-12 00:00:00

abstract：:The complete covalent structure of the gamma 2 subunit of bovine brain G proteins was determined by peptide mapping using matrix-assisted laser desorption ionization and electrospray ionization mass spectrometry and by partial sequencing using tandem mass spectrometry. Fragments were identified in proteolytic digests ...

journal_title：Biochemical and biophysical research communications

authors： Wilcox MD,Schey KL,Busman M,Hildebrandt JD

更新日期：1995-07-17 00:00:00

abstract：:Among the antimicrobial molecules produced by epithelial cells, DEFB4 is inducible in response to proinflammatory signals such as cytokines and bacterial molecules. Nontypeable Haemophilus influenzae (NTHi) is an important human pathogen that exacerbates chronic obstructive pulmonary disease in adult and causes otitis...

journal_title：Biochemical and biophysical research communications

authors： Woo JI,Kil SH,Pan H,Lee YJ,Lim DJ,Moon SK

更新日期：2014-01-17 00:00:00

abstract：:The whole-cell patch-clamp technique has been applied to elucidate the effects of H2O2 and the SH-group reagent 2,2'-dithio-bis(5-nitropyridine) (DTBNP) on Ca2+ currents of mouse pancreatic B-cells. We also tested the effect of DTBNP on the whole-cell K+ ATP current. DTBNP (20 and 100 mumol/l) blocked both the current...

journal_title：Biochemical and biophysical research communications

authors： Krippeit-Drews P,Britsch S,Lang F,Drews G

更新日期：1994-04-29 00:00:00

abstract：:When porcine adrenocortical microsomes were treated with Fe2+, enhanced production of malondialdehyde was observed as a result of membrane lipid peroxidation. By treatment of the microsomes with Fe2+, the activity of delta 5-3 beta-hydroxysteroid dehydrogenase coupled with delta 5-delta 4 isomerase, concentration of c...

journal_title：Biochemical and biophysical research communications

authors： Imataka H,Suzuki K,Tamaoki B

更新日期：1985-04-30 00:00:00

abstract：:Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum (ER)-membrane associated Ca(2+) sensor which activates store-operated Ca(2+) entry (SOCE). The homologue, STIM2 possesses a high sequence identity to STIM1 ( approximately 61%), while its role in SOCE seems to be distinct from that of STIM1. In order t...

journal_title：Biochemical and biophysical research communications

authors： Zheng L,Stathopulos PB,Li GY,Ikura M

更新日期：2008-04-25 00:00:00