当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > A CUGGU/UUGGU-specific MazF homologue from Methanohalobium evestigatum.

A CUGGU/UUGGU-specific MazF homologue from Methanohalobium evestigatum.

Abstract：

:MazF is a sequence-specific endoribonuclease or mRNA interferase, which cleaves RNA at a specific sequence. Since the expression of a specific gene or a group of specific genes can be regulated by MazF, expanding the repertoire of recognition sequences by MazF mRNA interferases is highly desirable for biotechnological and medical applications. Here, we identified a gene for a MazF homologue (MazFme) from Methanohalobium evestigatum, an extremely halophilic archaeon. In order to suppress the toxicity of MazFme to the E. coli cells, the C-terminal half of the cognate antitoxin MazEme was fused to the N-terminal end of MazFme. Since the fusion of the C-terminal half of MazEme to MazFme was able to neutralize MazFme toxicity, the MazEme-MazFme fusion protein was expressed in a large amount without any toxic effects. After purification of the MazEme, the free MazFme RNA cleavage specificity was determined by primer extension and synthetic ribonucleotides, revealing that MazFme is a CUGGU/UUGGU-specific endoribonuclease.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ishida Y,Inouye K,Ming O,Inouye M

doi

10.1016/j.bbrc.2019.08.076

subject

Has Abstract

pub_date

2019-10-20 00:00:00

pages

533-540

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)31593-1

journal_volume

518

pub_type

杂志文章

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