The effects of the beta3-adrenoceptor agonist BRL 35135 on UCP isoform mRNA expression.

abstract：:An increase in the intracellular cAMP concentration induces tyrosine phosphorylation of the epidermal growth factor receptor (EGFR) followed by activation of extracellular signal-regulated kinases 1/2 (ERK1/2). In this report we demonstrate that these effects of cAMP are mediated via activation of protein kinase A (PK...

journal_title：Biochemical and biophysical research communications

authors： Piiper A,Lutz MP,Cramer H,Elez R,Kronenberger B,Dikic I,Müller-Esterl W,Zeuzem S

更新日期：2003-02-21 00:00:00

abstract：:Smad2 is a crucial component of intracellular signaling by transforming growth factor-β (TGFβ). Here we describe that Smad2 is glycosylated, which is a novel for Smad2 post-translational modification. We showed that the Smad2 glycosylation was inhibited upon treatment of cells with 17β-estradiol, and was enhanced in c...

journal_title：Biochemical and biophysical research communications

authors： Gotoh T,Iwahana H,Kannan S,Marei RG,Mousa H,Elgamal M,Souchelnytskyi S

更新日期：2020-01-22 00:00:00

abstract：:The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each o...

journal_title：Biochemical and biophysical research communications

authors： Uchida K,Morita T,Sato T,Ogura T,Yamashita R,Noguchi S,Suzuki H,Nyunoya H,Miwa M,Sugimura T

更新日期：1987-10-29 00:00:00

abstract：:Reversal of the plasma membrane Na(+)/Ca(2+) exchanger (NCX) has been shown to mediate Ca(2+) influx in response to activation of G-protein linked receptors. Functional coupling of reverse-mode NCX with canonical transient receptor potential channels (TRPC), specifically TRPC6, has recently been demonstrated by our la...

journal_title：Biochemical and biophysical research communications

authors： Syyong HT,Poburko D,Fameli N,van Breemen C

更新日期：2007-06-15 00:00:00

abstract：:The pregnant hog ovary is a rich source of a novel exopeptidase that catalyzes the release, at pH 5.0, of collagen-related (P3-P2-P1) "triplets" such as Gly-Pro-Met, Gly-Pro-Arg, and Gly-Pro-Ala from arylamide derivatives, provided the N termini are unsubstituted. Corresponding derivatives of related (P2-P1) dipeptide...

journal_title：Biochemical and biophysical research communications

authors： McDonald JK,Hoisington AR,Eisenhauer DA

更新日期：1985-01-16 00:00:00

abstract：:In this paper we describe for the first time the inhibitory effect of three amphiphilic cations, trifluoperazine, propranolol and dibucaine on mitochondrial protein import. The amphiphilic cations did not affect binding of mitochondrial precursor proteins to mitochondria. Import into mitoplasts was affected in a simil...

journal_title：Biochemical and biophysical research communications

authors： Pavlov PF,Glaser E

更新日期：1998-11-09 00:00:00

abstract：:Pierisin-2 is a cytotoxic and apoptosis-inducing protein present in Pieris brassicae with a 91% homology in the deduced amino acid sequences to pierisin-1 from Pieris rapae. We earlier showed pierisin-1 to catalyze mono(ADP-ribosyl)ation of 2'-deoxyguanosine (dG) in DNA to form N2-(ADP-ribos-1-yl)-2'-deoxyguanosine, t...

journal_title：Biochemical and biophysical research communications

authors： Takamura-Enya T,Watanabe M,Koyama K,Sugimura T,Wakabayashi K

更新日期：2004-10-15 00:00:00

abstract：:The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common ...

journal_title：Biochemical and biophysical research communications

authors： Vlasuk GP,Miller J,Bencen GH,Lewicki JA

更新日期：1986-04-14 00:00:00

abstract：:Quantitative real-time RT-PCR was used to investigate the effects of prototypical drug-metabolizing enzyme inducers rifampicin (Rif), dexamethasone (Dex), and omeprazole (Ome) on mRNA expression levels of the housekeeping genes beta-actin (ACTB), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), beta-glucuronidase (GU...

journal_title：Biochemical and biophysical research communications

authors： Nishimura M,Koeda A,Suzuki E,Shimizu T,Kawano Y,Nakayama M,Satoh T,Narimatsu S,Naito S

更新日期：2006-08-04 00:00:00

abstract：:The smallest protein of hepatitis B virus, HBX, has been implicated in the development of liver diseases by interfering with normal cellular processes. Its role in cell proliferation has been unclear as both pro-apoptotic and anti-apoptotic activities have been reported. We showed molecular evidence that HBX induced a...

journal_title：Biochemical and biophysical research communications

authors： Lu YW,Chen WN

更新日期：2005-12-23 00:00:00

abstract：:Proteins modified by oxidants are rapidly degraded by intracellular proteases. Oxidatively modified superoxide dismutase (Ox-SOD) was degraded 2-8 times faster at both acidic and alkaline pH than the native protein in bovine cardiac tissue extracts. At acidic pH, Ox-SOD hydrolysis was stimulated by ATP and by non-hydr...

journal_title：Biochemical and biophysical research communications

authors： Strack PR,Waxman L,Fagan JM

更新日期：1996-02-15 00:00:00

abstract：:We report a rapid method for the covalent modification of commercially available amino-modified DNA oligonucleotides with a cysteine moiety. The resulting DNA-cysteine conjugates are versatile reagents for the efficient preparation of covalent DNA-protein conjugates by means of expressed protein ligation (EPL). The EP...

journal_title：Biochemical and biophysical research communications

authors： Lovrinovic M,Niemeyer CM

更新日期：2005-09-30 00:00:00

abstract：:We previously showed that SIRT1 deacetylase inhibits proliferation of hepatocellular carcinoma cells expressing hepatitis B virus (HBV) X protein (HBX), by destabilization of β-catenin. Here, we report another role for SIRT1 in HBX-mediated resistance to oxidative stress. Ectopic expression and enhanced activity of SI...

journal_title：Biochemical and biophysical research communications

authors： Srisuttee R,Koh SS,Malilas W,Moon J,Cho IR,Jhun BH,Horio Y,Chung YH

更新日期：2012-12-07 00:00:00

abstract：:Vomeronasal organs of female Wistar rats were exposed with sprayed urine preparations of male Wistar rats prior to sacrifice. Exposure to crude urine and ultrafiltrated urine preparation (<5000 Da) induced significant Fos expression, which is correlated with cellular activity, in the mitral/tufted cell layer of the ac...

journal_title：Biochemical and biophysical research communications

authors： Tsujikawa K,Kashiwayanagi M

更新日期：1999-06-24 00:00:00

abstract：:Unlike unsaturated fatty acids, which almost fully activated purified brain protein kinase C in a phosphatidylserine- and Ca2(+)-free reaction, related methyl esters were poorly active in vitro. In contrast, methyl arachidonate was revealed to be as potent as arachidonic acid in activating protein kinase C in intact p...

journal_title：Biochemical and biophysical research communications

authors： Fan XT,Huang XP,Da Silva C,Castagna M

更新日期：1990-06-29 00:00:00

abstract：:Xylan from Rhodymenia palmata binds to the cellobiohydrolase I from Trichoderma reesei (CBH I) or its core protein, inhibiting their activity. Adsorption onto microcrystalline cellulose (Avicel) is reduced approximately 30% for intact CBH I and nearly 50% for the core, whereas the effects with cellobiose are negligibl...

journal_title：Biochemical and biophysical research communications

authors： Abuja PM,Pilz I,Tomme P,Claeyssens M

更新日期：1989-12-15 00:00:00

abstract：:High ethanol intake is considered to impair insulin sensitivity. In the present study, we investigated the acute and chronic effects of ethanol intake on glucose metabolism and insulin signal transduction. Hyperinsulinemic-euglycemic clamp studies revealed 70% and 51% decreases in the glucose infusion rate, 52% and 31...

journal_title：Biochemical and biophysical research communications

authors： Onishi Y,Honda M,Ogihara T,Sakoda H,Anai M,Fujishiro M,Ono H,Shojima N,Fukushima Y,Inukai K,Katagiri H,Kikuchi M,Oka Y,Asano T

更新日期：2003-04-11 00:00:00

abstract：:The D protein (16 kDa) is part of a protein core, common to U1, U2, U5, U4/U6 small nuclear RNA containing ribonucleoprotein particles. Monoclonal antibodies reactive with the D protein were used in quantitative dot blotting and Western blotting to demonstrate that this protein was a component of salt resistant nuclea...

journal_title：Biochemical and biophysical research communications

authors： Harris SG,Smith HC

更新日期：1988-05-16 00:00:00

abstract：:Triiodothyronine (T3) effects on cultured Sertoli cells from immature rats were investigated by evaluating the production of androgen binding protein (ABP) a biochemical marker of Sertoli cell function. The results demonstrate that T3 administration to the rat as well as T3 addition to the culture medium specifically ...

journal_title：Biochemical and biophysical research communications

authors： Fugassa E,Palmero S,Gallo G

更新日期：1987-02-27 00:00:00

abstract：:To study the role of Rab3A in regulated secretion, recombinant Rab3A protein plus various guanine nucleotides were perfused into bovine adrenal chromaffin cells via a patch pipette, and depolarization-evoked catecholamine secretion from individual cells was measured by amperometry. Rab3A plus GTP, GDP, and GTP gamma S...

journal_title：Biochemical and biophysical research communications

authors： Lin CG,Pan CY,Kao LS

更新日期：1996-04-25 00:00:00

abstract：:To examine the possibility that inter-individual differences in splicing partially explain the observed differences in CYP2D6 activity, we amplified its full-length cDNA in 96 human liver RNA samples and discovered five splice variants: intron 5 retention, intron 6 retention, intron 5 and intron 6 double retention, ex...

journal_title：Biochemical and biophysical research communications

authors： Denson J,Wu Y,Yang W,Zhang J

更新日期：2005-05-06 00:00:00

abstract：:Lactoferrin (LF) is a multifunctional, iron-binding glycoprotein in mammalian secretions, such as breast milk, and has several beneficial effects for human health. However, how these effects are exerted at the cellular level is still largely unknown. In this study, we investigated the effects of LF on autophagy activi...

journal_title：Biochemical and biophysical research communications

authors： Aizawa S,Hoki M,Yamamuro Y

更新日期：2017-11-04 00:00:00

abstract：:Bovine brain smg p25A, a guanine nucleotide-binding protein with a Mr of about 25,000, bound specifically GTP, guanosine 5'-(3-O-thio)triphosphate (GTP gamma S) and GDP. The initial velocities of the binding of GTP gamma S to GDP-bound smg p25A and the dissociation of GDP from this protein increased by decreasing Mg2+...

journal_title：Biochemical and biophysical research communications

authors： Shoji I,Kikuchi A,Kuroda S,Takai Y

更新日期：1989-07-14 00:00:00

abstract：:The nuclear enzyme poly(ADP-ribosyl) transferase (pADPRT) catalyzes the formation of poly(ADP-ribose) from NAD+. Several nuclear proteins and pADPRT itself are targets for the modification by poly(ADP-ribosyl)ation. It is demonstrated here that poly(ADP-ribose) or pADPRT automodified with poly(ADP-ribose) interacts no...

journal_title：Biochemical and biophysical research communications

authors： Mayer-Kuckuk P,Ullrich O,Ziegler M,Grune T,Schweiger M

更新日期：1999-06-16 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis. However, their hallmark ability is that play a pivo...

journal_title：Biochemical and biophysical research communications

authors： Xiao YT,Xiang LX,Shao JZ

更新日期：2007-10-26 00:00:00

abstract：:It has been well documented that tumor suppressor p53 is mutated in about 50% of all human tumors. p53 status might be one of the critical determinants for the chemo-sensitivity of human tumors. In the present study, we have found that p53 family member p73 as well as 14-3-3sigma is down-regulated in response to adria...

journal_title：Biochemical and biophysical research communications

authors： Sang M,Li Y,Ozaki T,Ono S,Ando K,Yamamoto H,Koda T,Geng C,Nakagawara A

更新日期：2006-08-18 00:00:00

abstract：:Ku70 is a protein that finds itself at the heart of several important cellular processes. It is essential to the non-homologous end joining pathway as a part of the DNA-end binding complex, required for proper maintenance of telomeres and contributes to DNA damage recognition and regulation of apoptosis. Forces that r...

journal_title：Biochemical and biophysical research communications

authors： Yurchenko V,Xue Z,Gama V,Matsuyama S,Sadofsky MJ

更新日期：2008-02-01 00:00:00

abstract：:Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into four primary cilia (PC)-positive GCs and 12 PC-negative GCs. The ...

journal_title：Biochemical and biophysical research communications

authors： Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

更新日期：2021-02-05 00:00:00

abstract：:Electrophoretic analysis of murine anterior pituitary extract revealed five major proteins of Mr 13,000-18,000 (designated P13, P14, P16, P17, and P18 according to Mr), three of which, P16, P17, and P18, were markedly influenced by estradiol benzoate and perphenazine in a manner similar to that of growth hormone, and ...

journal_title：Biochemical and biophysical research communications

authors： Sinha YN,Jacobsen BP

更新日期：1988-10-14 00:00:00

abstract：:The signal transduction of human 12(S)-lipoxygenase and the regulation of gene activation, induced by epidermal growth factor (EGF), are discussed in this review article. Treatment of human epidermoid carcinoma A431 cells with EGF induces the gene expression of human 12(S)-lipoxygenase, and two Sp1 binding sites resid...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Chen BK

更新日期：2005-12-09 00:00:00