Lactoferrin promotes autophagy via AMP-activated protein kinase activation through low-density lipoprotein receptor-related protein 1.

abstract：:It is controversial whether osteopontin (OP) is expressed in glomeruli and involved in glomerular diseases. We examined whether the OP expression is present at gene and protein levels in cultured rat mesangial cells (MCs). Northern blotting revealed a 1.7 kb OP-mRNA expression in MCs. Fetal calf serum (FCS) and TNF-al...

journal_title：Biochemical and biophysical research communications

authors： Nagasaki T,Ishimura E,Shioi A,Jono S,Inaba M,Nishizawa Y,Morii H,Otani S

更新日期：1997-04-07 00:00:00

abstract：:Two cDNA clones for the transacylase protein of the branched chain ketoacid dehydrogenase complex [E.C. 1.2.4.4] have been isolated from a human fetal liver cDNA expression library in lambda gt11 using antibody selection. By selective antibody elution from nitrocellulose filters containing the fusion proteins, it was ...

journal_title：Biochemical and biophysical research communications

authors： Litwer S,Danner DJ

更新日期：1985-09-16 00:00:00

abstract：:Cytotoxic lymphocytes utilize granule associated serine proteases (granzymes) and perforin to induce apoptosis. Although the importance of granzyme B has been established by gene ablation experiments, biochemical events initiated by the granzyme remain enigmatic. We show here that exposure of Jurkat cells to granzyme ...

journal_title：Biochemical and biophysical research communications

authors： Froelich CJ,Hanna WL,Poirier GG,Duriez PJ,D'Amours D,Salvesen GS,Alnemri ES,Earnshaw WC,Shah GM

更新日期：1996-10-23 00:00:00

abstract：:Murine interleukin 6 (mIL-6) has been synthesized as a fusion protein using a lac operon inducible plasmid in Escherichia coli. The first 8 amino acids are from the N-terminus of bacterial beta-galactosidase and the last 175 amino acids are from residue number 12 to the end of native mIL-6. This fusion protein is equi...

journal_title：Biochemical and biophysical research communications

authors： Simpson RJ,Moritz RL,Van Roost,Van Snick J

更新日期：1988-11-30 00:00:00

abstract：:Aralin from Aralia elata is a newly identified type II ribosome- inactivating protein, which preferentially induces apoptosis in cancer cells. In this study, we identified that the aralin receptor is a 110-kDa high-density lipoprotein-binding protein (HDLBP), which functions as a HDL receptor. The sensitivities of tum...

journal_title：Biochemical and biophysical research communications

authors： Otsuka H,Gotoh Y,Komeno T,Ono T,Kawasaki Y,Iida N,Shibagaki Y,Hattori S,Tomatsu M,Akiyama H,Tashiro F

更新日期：2014-10-10 00:00:00

abstract：:A simple procedure based upon the principle discovered by Dürr et al. (Arch. Microbiol. (1975) 105, 319-327) was used to measure the intracellular distribution of enzymes in S. cerevisiae grown under both glucose repression and derepression. No substantial hexokinase activity was found to be associated with cellular o...

journal_title：Biochemical and biophysical research communications

authors： Kovác L,Nelson BD,Ernster L

更新日期：1986-01-14 00:00:00

abstract：:We have recently reported that Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion, unveiling the first underlying mechanism of a linker protein required for maintenance of centrosome cohesion. The minichromosome maintenance (MCM) proteins 2-7 have long been noticed to lo...

journal_title：Biochemical and biophysical research communications

authors： Kong L,Yin H,Yuan L

更新日期：2017-08-05 00:00:00

abstract：:Four peptides possessing both natriuretic activity and smooth muscle relaxant activity were isolated from rat atrium and their amino acid sequences determined. The four peptides designated ANF-I, ANF-II, ANF-III and ANF-IV containing 35, 31, 30 and 25 amino acid residues, respectively, were obtained in a molar ratio o...

journal_title：Biochemical and biophysical research communications

authors： Misono KS,Grammer RT,Fukumi H,Inagami T

更新日期：1984-09-17 00:00:00

abstract：:Specific, saturable EGF receptors were demonstrated in isolated rat pancreatic acini. Binding of EGF to these receptors was one-half maximal at 20 min and maximal at 120 min. Scatchard analyses revealed a single order of binding sites with a Kd of 4.90 nM. Following binding, EGF was rapidly internalized and converted ...

journal_title：Biochemical and biophysical research communications

authors： Korc M,Matrisian LM,Planck SR,Magun BE

更新日期：1983-03-29 00:00:00

abstract：:Although cancer patients initially respond well to chemotherapy, they eventually develop resistance and relapse. In this work, we demonstrate that eIF4E-targeting therapy is a potential sensitizing strategy for overcoming chemoresistance and progression in cancer. We show that ribavirin, an anti-viral drug and pharmac...

journal_title：Biochemical and biophysical research communications

authors： Xi C,Wang L,Yu J,Ye H,Cao L,Gong Z

更新日期：2018-09-18 00:00:00

abstract：:Heat shock proteins 60 (hsp60) and 10 (hsp10) are essential for the formation and restoration of many supramolecular structures. For reconstitution of these structures, we isolated stable hsps of 61kDa and 12kDa, which are similar to hsp60 and hsp10, respectively, from the supernatant fraction of thermophilic bacteriu...

journal_title：Biochemical and biophysical research communications

authors： Tamada H,Ohta T,Hamamoto T,Otawara-Hamamoto Y,Yanagi M,Hiraiwa H,Hirata H,Kagawa Y

更新日期：1991-08-30 00:00:00

abstract：:Carcinogenesis is a long process that results in the accumulation of genetic alterations primarily in genes involved in the regulation of signalling pathways relevant for the regulation of cell growth and the cell cycle. Alteration of additional genes regulating cell adhesion and migration, angiogenesis, apoptosis, an...

journal_title：Biochemical and biophysical research communications

authors： Ramírez de Molina A,Rodríguez-González A,Gutiérrez R,Martínez-Piñeiro L,Sánchez J,Bonilla F,Rosell R,Lacal J

更新日期：2002-08-23 00:00:00

abstract：:Peptides containing phosphonate based non-hydrolyzable phosphotyrosyl (pTyr) mimetics previously have been shown to be competitive inhibitors of protein-tyrosine phosphatases (PTPs). These agents suffer from low cellular penetration which is partially attributable to ionization of the phosphonate group at physiologica...

journal_title：Biochemical and biophysical research communications

authors： Kole HK,Akamatsu M,Ye B,Yan X,Barford D,Roller PP,Burke TR Jr

更新日期：1995-04-26 00:00:00

abstract：:Disturbances of serotonergic pathways have been implicated in a wide variety of neuropsychiatric disorders such as depression, anxiety, migraine, and substance abuse. Genetic variation in genes coding for serotonin receptor proteins might well be involved in the genetic predisposition to these diseases and/or of pharm...

journal_title：Biochemical and biophysical research communications

authors： Nöthen MM,Erdmann J,Shimron-Abarbanell D,Propping P

更新日期：1994-12-15 00:00:00

abstract：:Recent studies revealed dramatic changes in circadian clock genes' expression during the perinatal period. In this study, we characterized DNA methylation for three clock genes mPer1, mPer2, and mCry1 at their selected promoter regions during development. Results for the suprachiasmatic nucleus (SCN) and liver (at emb...

journal_title：Biochemical and biophysical research communications

authors： Ji Y,Qin Y,Shu H,Li X

更新日期：2010-01-22 00:00:00

abstract：:A human thyroid cDNA library was screened by hybridization with a dog thyrotropin receptor (TSHr) cDNA. Sequencing of the resulting clones identified a 2292 residue open reading frame encoding a 744 amino acid mature polypeptide presenting 90.3% similarity with the dog TSHr. Two major transcripts (4.6 and 4.4 kilobase...

journal_title：Biochemical and biophysical research communications

authors： Libert F,Lefort A,Gerard C,Parmentier M,Perret J,Ludgate M,Dumont JE,Vassart G

更新日期：1989-12-29 00:00:00

abstract：:Peptides simultaneously produced during maturation and degradation of peptidergic hormones and functional proteins have recently become a great interest because they display unpredictably different biological roles than the parent proteins. Namely, we discovered two novel functional cryptic peptides, mitocryptide-1 (M...

journal_title：Biochemical and biophysical research communications

authors： Seki T,Fukamizu A,Kiso Y,Mukai H

更新日期：2011-01-07 00:00:00

abstract：:In this study we identified a potential pro-apoptotic caspase gene, Bombyx mori(B. mori)ICE-2 (BmICE-2) which encoded a polypeptide of 284 amino acid residues, including a (169)QACRG(173) sequence which surrounded the catalytic site and contained a p20 and a p10 domain. BmICE-2 expressed in Escherichia coli (E. coli) ...

journal_title：Biochemical and biophysical research communications

authors： Yi HS,Pan CX,Pan C,Song J,Hu YF,Wang L,Pan MH,Lu C

更新日期：2014-02-28 00:00:00

abstract：:miRNAs are recently found playing important roles in osteogenesis. In this study, we identified that miR-222-3p decreased during osteogenic differentiation of human mesenchymal stem cells (hBMSCs) using Quantitative Real-Time Reverse Transcription PCR (qRT-PCR). Furthermore, we investigated the effect of miR-222-3p on...

journal_title：Biochemical and biophysical research communications

authors： Yan J,Guo D,Yang S,Sun H,Wu B,Zhou D

更新日期：2016-02-12 00:00:00

abstract：:Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases but its etiology is unclear. Alpha-synuclein (alpha-SN) is a major component of Lewy bodies and Lewy neurites, and its missense mutations, A30P and A53T, cause familial PD. In PD, alpha-SN-positive glial inclusions are distributed mainly ...

journal_title：Biochemical and biophysical research communications

authors： Kohno R,Sawada H,Kawamoto Y,Uemura K,Shibasaki H,Shimohama S

更新日期：2004-05-21 00:00:00

abstract：:Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known functions other than mineralization. Recently, RNA was identified in e...

journal_title：Biochemical and biophysical research communications

authors： Mitton E,Gohr CM,McNally MT,Rosenthal AK

更新日期：2009-10-23 00:00:00

abstract：:We have selected calcium ionophore (A23187)-resistant cells (AR-7) in a human promyelocytic leukemia cell line, HL-60. AR-7 showed approximately 8.5-fold resistance to A23187 compared with the wild type cells after continuous exposure for 3 days. AR-7 had cross resistance to ionomycin (4.6-fold) and thapsigargin (340-...

journal_title：Biochemical and biophysical research communications

authors： Kubota M,Kataoka A,Okuda A,Bessho R,Lin YW,Wakazono Y,Usami I,Akiyama Y,Furusho K

更新日期：1995-08-15 00:00:00

abstract：:Nitric oxide synthase (EC 1.14.23) substrate analog inhibitors NG-monomethyl-L-Arg, NG-nitro-L-Arg, NG-nitro-L-Arg methyl ester, and aminoguanidine were examined as potential inhibitors of rat liver arginase (EC 3.5.3.1). NG-nitro-L-Arg was found to inhibit arginase catalyzed conversion of L-Arg to L-Orn at pH 7.5 wit...

journal_title：Biochemical and biophysical research communications

authors： Robertson CA,Green BG,Niedzwiecki L,Harrison RK,Grant SK

更新日期：1993-12-15 00:00:00

abstract：:NF-kappaB plays an important role in oncogenesis. Recently, we have demonstrated that loss of p53 function enhances DNA binding and transcriptional activities of NF-kappaB via IKKalpha and IKKbeta, and that glycolysis, activated by NF-kappaB, has an integral role in oncogene-induced cell transformation. Here, we show ...

journal_title：Biochemical and biophysical research communications

authors： Kawauchi K,Araki K,Tobiume K,Tanaka N

更新日期：2008-07-18 00:00:00

abstract：:Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement...

journal_title：Biochemical and biophysical research communications

authors： Mo S,Hua Y

更新日期：2018-06-22 00:00:00

abstract：:Transforming growth factor (TGF)-beta1, a cytokine released into the cerebrospinal fluid (CSF) after intraventricular hemorrhage (IVH), stimulates the expression of the components of the extracellular matrix (ECM), which causes progressive ventricular dilatation by impaired CSF absorption. Matrix metalloproteinase-9 (...

journal_title：Biochemical and biophysical research communications

authors： Okamoto T,Takahashi S,Nakamura E,Nagaya K,Hayashi T,Fujieda K

更新日期：2009-06-12 00:00:00

abstract：:Exploring the molecular mechanisms that regulate the osteogenesis of human mesenchymal stem cells (hMSCs) will bring us more efficient methods for improving the treatment of bone-related diseases. In this study, we analyzed the effects of miR-31 on the osteogenesis of hMSCs. The overexpression of miR-31 repressed the ...

journal_title：Biochemical and biophysical research communications

authors： Xie Q,Wang Z,Bi X,Zhou H,Wang Y,Gu P,Fan X

更新日期：2014-03-28 00:00:00

abstract：:The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common ...

journal_title：Biochemical and biophysical research communications

authors： Vlasuk GP,Miller J,Bencen GH,Lewicki JA

更新日期：1986-04-14 00:00:00

abstract：:Connexin 43 (Cx43), a ubiquitous connexin expressed in the heart and skin, is associated with a variety of hereditary conditions. Therefore, the characterization of Cx43-interacting proteins and their dynamics is important to understand not only the molecular mechanisms underlying pathological malfunction of gap junct...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Choi JW,Shin S,Lee J,Seo HH,Lim S,Lee S,Joo HC,Kim SW,Hwang KC

更新日期：2017-09-16 00:00:00

abstract：:Mutations of the GJB2 gene, encoding connexin 26, are the most common cause of hereditary congenital hearing loss in many countries and account for up to 50% of cases of autosomal-recessive non-syndromic deafness. By contrast, only a few GJB2 mutations have been reported to cause an autosomal-dominant form of non-synd...

journal_title：Biochemical and biophysical research communications

authors： Melchionda S,Bicego M,Marciano E,Franzè A,Morgutti M,Bortone G,Zelante L,Carella M,D'Andrea P

更新日期：2005-11-25 00:00:00